INT45147

Context Info Confidence 0.58 First Reported 1983 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 21 Total Number 23 Disease Relevance 6.18 Pain Relevance 3.98

cellular_component (C2)

Anatomy Link Frequency fossa 1 interspace 1 nerve 1 whisker 1 skin 1 C2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dorsal horn 2 99.84 Paracetamol 8 99.56 Pain 40 98.92 qutenza 7 98.76 abdominal pain 2 98.40 neuralgia 13 97.36 Neuropathic pain 1 97.04 Arthritis 1 94.20 psoriasis 3 92.04 imagery 217 91.80

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 16 99.96 Telangiectasia 2 99.96 Cough 8 99.72 Edema 5 99.64 Pathologic Constriction 10 99.56 Disease 42 99.36 Pain 22 98.92 Cardiovascular Disease 43 98.64 Abdominal Pain 2 98.40 Arthritis 2 98.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

METHODS: Sixty patients undergoing abdominal hysterectomy of ASA status I-II were randomly divided into 3 equal groups: C2 group was pretreated with epidural clonidine 2 microg/kg at the L2-3 interspace, 15 min later, epidural anesthesia was performed with 0.5% levobupivacaine, and then 0. 4 microg/ml combined with levobupivacaine 2 mg/ml was given for postoperative epidural patient-controlled analgesia.

Gene_expression (group) of C2 in interspace

1) Confidence 0.58 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18646709 Disease Relevance 0 Pain Relevance 0

Cough sensitivity (C2) expressed as geometric mean (95% CI) of CAPS concentration was 0.13 micromol/l (0.06-0.31) in 26 patients with atopic dermatitis (10 M, 16 F; mean age 41 yr), 5.51 micromol/l (1.33-22.90) in 22 patients with psoriasis (11 M, 11 F; mean age 46 yr) and 4.29 micromol/l (2.54-7.26) in 24 controls.

Gene_expression (expressed) of C2 associated with psoriasis, qutenza, eczema and cough

2) Confidence 0.53 Published 2003 Journal Pulm Pharmacol Ther Section Abstract Doc Link 12850122 Disease Relevance 1.16 Pain Relevance 0.52

Increases in metabolic activity were seen in the dorsal horn at the level of C1 and C2 as might be predicted from the cervical origin of the nerve.

Gene_expression (level) of C2 in nerve associated with dorsal horn

3) Confidence 0.49 Published 1997 Journal Pain Section Abstract Doc Link 9414053 Disease Relevance 0.38 Pain Relevance 0.42

For this reason, we recorded a local field potential (LFP) from barrel C2/3 at a depth of 700 to 850 ?

Gene_expression (/) of C2

4) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2071938 Disease Relevance 0 Pain Relevance 0

Additionally, the activations of PKC and p38, but not PKA, calcium/calmodulin-dependent protein kinase II, and ERK, by C2 ceramide play important regulatory roles in C2 ceramide-induced proENK mRNA expression via activating the CREB.

Gene_expression (expression) of C2

5) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0

However, calphostin C (a PKC inhibitor) and or SB203580 (a p38 inhibitor) partially but significantly reduced C2 ceramide-induced proENK mRNA expression as well as phospho-CREB level.

Gene_expression (expression) of C2

6) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0

RESULTS: The patient underwent resection of the right cerebellar mass, posterior fossa decompression, C1 and C2 laminectomies, and a duraplasty.

Gene_expression (resection) of C2 in fossa

7) Confidence 0.37 Published 2004 Journal Can J Neurol Sci Section Body Doc Link 15595264 Disease Relevance 0.17 Pain Relevance 0

Twenty patients (mean age 48.7 years) were identified who had undergone C2 and/or C3 ganglionectomies for intractable occipital pain and a retrospective chart review undertaken.

Gene_expression (ganglionectomies) of C2 associated with pain

8) Confidence 0.32 Published 2008 Journal Stereotact Funct Neurosurg Section Abstract Doc Link 18216457 Disease Relevance 0.93 Pain Relevance 0.93

Separate ANOVAs followed by respective contrasts were performed for the three intrinsic signal phases of the ipsi-ischemic C2 representation, as well as for the initial dip signal phase of the ipsi-ischemic B1 representation and the initial dip signal phase of the C2 representation contralateral to the pMCAO.

Gene_expression (representation) of C2

9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890583 Disease Relevance 0 Pain Relevance 0.09

Prior to pMCAO, no differences between groups in area or peak amplitude of the ipsi-ischemic C2 representation were observed.

Gene_expression (representation) of C2

10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890583 Disease Relevance 0.13 Pain Relevance 0.08

Indeed, the ipsi-ischemic C2 representation disappeared and substantial infarct was observed in all +0 h distal subjects despite the fact that whisker stimulation was delivered immediately following occlusion (Figure 7, middle column).

Gene_expression (representation) of C2 in whisker

11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890583 Disease Relevance 0 Pain Relevance 0.03

The C2 ceramide-induced proENK mRNA expression was not changed significantly by the pretreatment with H89 (a PKA inhibitor), KN62 (a calcium/calmodulin-dependent protein kinase II inhibitor), and PD98059 (an ERK pathway inhibitor).

Gene_expression (expression) of C2

12) Confidence 0.25 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0

Moreover, the levels of C1 as well as those of C2 and C3 were markedly increased in the peripheral serum of day-21 rats within 15 min of LH administration.

Gene_expression (levels) of C2

13) Confidence 0.23 Published 1984 Journal Endocrinology Section Abstract Doc Link 6697963 Disease Relevance 0.08 Pain Relevance 0.08

This hypothesis led to surgical exploration of the C-3 and C-2 roots in a young patient with post-traumatic arthritic occipital neuralgia.

Gene_expression (exploration) of C-2 associated with neuralgia, occipital neuralgia and arthritis

14) Confidence 0.11 Published 1983 Journal Neurosurgery Section Abstract Doc Link 6835506 Disease Relevance 0.64 Pain Relevance 0.58

Spinal images were evaluated for spinal fluid collections, dural enhancement, dilated epidural veins, a thickened or enlarged ventral lateral epidural venous plexus, high T2 signal intensity between the spinous processes of C1 and C2 (C1-C2 sign), structural abnormalities, canal attenuation or cord compression, and active contrast extravasation.

Gene_expression (processes) of C2 in ventral

15) Confidence 0.11 Published 2010 Journal AJR Am J Roentgenol Section Body Doc Link 20651205 Disease Relevance 0 Pain Relevance 0

Laboratory examination showed reduced levels of CH50, C2, C4, and C1 inhibitor (C1-INH).

Gene_expression (levels) of C2

16) Confidence 0.10 Published 2005 Journal Mod Rheumatol Section Abstract Doc Link 17029094 Disease Relevance 0.88 Pain Relevance 0.19

This observation is consistent with former studies showing that the NR1 splice variant containing the C2-cassette is the predominant version of the two alternative carboxy-terminal isoforms NR1-C2 and NR1-C2?

Gene_expression (containing) of C2

17) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.05

These results suggest that the age-related difference in toxicity would be attributed to a higher expression of CYP3A13, producing the active metabolite of APAP as well as the lower expression of the detoxification enzyme, GSTY2c, in adult rats.

Gene_expression (expression) of GSTY2c associated with toxicity and paracetamol

18) Confidence 0.08 Published 2006 Journal J Toxicol Sci Section Abstract Doc Link 17202762 Disease Relevance 0.34 Pain Relevance 0.58

The EEG was recorded from C3, C1, Cz, C2 and C4 including computed bipolar recordings C4/C3 and C2/C1.

Gene_expression (including) of C2

19) Confidence 0.06 Published 1983 Journal Hum Neurobiol Section Abstract Doc Link 6629877 Disease Relevance 0 Pain Relevance 0.15

The EEG was recorded from C3, C1, Cz, C2 and C4 including computed bipolar recordings C4/C3 and C2/C1.

Gene_expression (including) of C2

20) Confidence 0.06 Published 1983 Journal Hum Neurobiol Section Abstract Doc Link 6629877 Disease Relevance 0 Pain Relevance 0.16

General Comments

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