INT4545

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Context Info
Confidence 0.53
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 10.08
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Nox1) signal transduction (Nox1) transport (Nox1)
oxidoreductase activity (Nox1) plasma membrane (Nox1) extracellular matrix organization (Nox1)
Anatomy Link Frequency
SK-MEL-28 1
plasma 1
melanocytes 1
heart 1
Nox1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 37 99.98 Very High Very High Very High
Clonidine 4 99.88 Very High Very High Very High
imagery 124 97.76 Very High Very High Very High
Inflammation 10 86.64 High High
headache 1 80.44 Quite High
cINOD 6 36.52 Quite Low
metalloproteinase 1 30.56 Quite Low
agonist 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 20 99.76 Very High Very High Very High
Diabetes Mellitus 234 99.70 Very High Very High Very High
Hypertension 29 99.36 Very High Very High Very High
Hyperglycemia 8 99.22 Very High Very High Very High
Apoptosis 10 98.52 Very High Very High Very High
Cancer 13 96.72 Very High Very High Very High
Experimental Melanoma 4 96.56 Very High Very High Very High
Death 5 95.24 Very High Very High Very High
INFLAMMATION 10 86.64 High High
Diabetic Cardiomyopathies 32 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NADH oxidase activity was inhibited preferentially in the A-375 melanoma cells but not in the primary melanocytes, by capsaicin.
Negative_regulation (inhibited) of NADH oxidase in melanocytes associated with qutenza and skin cancer
1) Confidence 0.53 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943687 Disease Relevance 0.69 Pain Relevance 0.56
Inhibition of growth and the NADH oxidase by capsaicin could be induced in resistant SK-MEL-28 melanoma cells by co-administration of capsaicin with t-butyl hydroperoxide, a mild oxidising agent.
Negative_regulation (Inhibition) of NADH oxidase in SK-MEL-28 associated with qutenza and skin cancer
2) Confidence 0.53 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943687 Disease Relevance 0.75 Pain Relevance 0.60
With B16 mouse melanoma, capsaicin inhibited both the NADH oxidase activity and growth in culture.
Negative_regulation (inhibited) of NADH oxidase associated with qutenza and skin cancer
3) Confidence 0.53 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943687 Disease Relevance 0.88 Pain Relevance 0.68
Metoprolol did not inhibit succinoxidase, and was one-fourth as active as propranolol for inhibition of NADH-oxidase.
Negative_regulation (inhibition) of NADH-oxidase
4) Confidence 0.37 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197930 Disease Relevance 0.39 Pain Relevance 0.10
The findings correlate the inhibition of cell surface NADH oxidase activity with inhibition of growth and capsaicin-induced apoptosis, and also suggest that the extent of inhibition may relate to the oxidation state of the plasma membrane.
Negative_regulation (inhibition) of NADH oxidase in plasma associated with qutenza and apoptosis
5) Confidence 0.34 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943687 Disease Relevance 0.85 Pain Relevance 0.66
Hydrochlorothiazide, hydralazine, ans clonidine also inhibited CoQ10-NADH-oxidase.
Negative_regulation (inhibited) of CoQ10-NADH-oxidase associated with clonidine
6) Confidence 0.32 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197930 Disease Relevance 0.39 Pain Relevance 0.10
Diazoxide and propranolol significantly inhibited the CoQ10-succinoxidase and CoQ10-NADH-oxidase, respectively.
Negative_regulation (inhibited) of CoQ10-NADH-oxidase
7) Confidence 0.32 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197930 Disease Relevance 0.40 Pain Relevance 0.09
Eight clinically used anti-hypertensive drugs have now been tested for inhibition of two mitochondrial coenzyme Q10-enzymes of heart tissue, succinoxidase and NADH-oxidase.
Negative_regulation (inhibition) of NADH-oxidase in heart associated with hypertension
8) Confidence 0.27 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197930 Disease Relevance 0.36 Pain Relevance 0.08
In the proposed study, ordinary least squares regression-based QSAR models were developed for three toxicological endpoints: mouse oral LD(50), inhibition of NADH-oxidase (EC(50) NADH-Ox) and the effect on mitochondrial membrane potential (EC(50) DeltaPsim).
Negative_regulation (inhibition) of NADH-oxidase
9) Confidence 0.21 Published 2009 Journal SAR QSAR Environ Res Section Abstract Doc Link 20024809 Disease Relevance 0.40 Pain Relevance 0.08
In contrast to the nearly 50% decline in cardiac NADH-linked electron transport chain activity (NADH oxidase) induced by diabetes, complex I activity declined 21.2% (P value ?
Negative_regulation (decline) of NADH oxidase associated with diabetes mellitus
10) Confidence 0.17 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC1805425 Disease Relevance 1.02 Pain Relevance 0.03
After 4 weeks of hyperglycemia one marker of mitochondrial function, NADH oxidase activity, was decreased to 50% of control animals.
Negative_regulation (decreased) of NADH oxidase associated with hyperglycemia
11) Confidence 0.17 Published 2007 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC1805425 Disease Relevance 1.11 Pain Relevance 0.25
Therefore this decrement is, in part, responsible for the observed loss in NADH oxidase activity.
Negative_regulation (loss) of NADH oxidase
12) Confidence 0.17 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC1805425 Disease Relevance 0.95 Pain Relevance 0
As shown in Figure 6, diabetes resulted in a decline in NADH oxidase activity of approximately 50% relative to control values.
Negative_regulation (decline) of NADH oxidase associated with diabetes mellitus
13) Confidence 0.17 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC1805425 Disease Relevance 0.93 Pain Relevance 0.04
scavenger, superoxide dismutase1 (SOD1) and downregulation of Nox-1, -2, and -4 genes encoding subunits of the O2·?
Negative_regulation (downregulation) of Nox-1
14) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.42 Pain Relevance 0.04
The NADH oxidase activity inhibited by mAb 12.1 also was inhibited by the quinone site inhibitor capsaicin (8-methyl- N-vanillyl-6-noneamide).
Negative_regulation (inhibited) of NADH oxidase associated with qutenza
15) Confidence 0.08 Published 2002 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 11941450 Disease Relevance 0.56 Pain Relevance 0.10

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