INT46052

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Context Info
Confidence 0.06
First Reported 1983
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 3.29
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
cardiomyocytes 2
brain 2
plasma 1
neuronal 1
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 20 99.98 Very High Very High Very High
Morphine 12 99.84 Very High Very High Very High
imagery 18 95.14 Very High Very High Very High
Hippocampus 43 93.52 High High
narcan 2 92.16 High High
antagonist 1 91.76 High High
opiate 1 91.32 High High
Inflammatory response 15 85.84 High High
dexamethasone 1 84.00 Quite High
addiction 3 65.84 Quite High
Disease Link Frequency Relevance Heat
Injury 14 100.00 Very High Very High Very High
INFLAMMATION 80 99.86 Very High Very High Very High
Alzheimer's Dementia 18 99.24 Very High Very High Very High
Infection 36 97.72 Very High Very High Very High
Disease 192 97.40 Very High Very High Very High
Death 45 97.16 Very High Very High Very High
Bacillus Anthracis Infection 84 96.80 Very High Very High Very High
Stress 81 93.76 High High
Body Weight 4 87.28 High High
Ataxia 1 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Age-related increased superoxide production in brain in vivo is attenuated by inhibition of NADPH oxidase or by treatment with a superoxide dismutase mimetic, and is emulated by increased levels of plasma IL-6
Negative_regulation (inhibition) of NADPH in plasma
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.05 Pain Relevance 0.07
Therefore, Nox2 represents the only apocynin-inhibitable NADPH oxidase isoform expressed in aged mouse brain.
Negative_regulation (apocynin-inhibitable) of NADPH in brain
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
To confirm that elevation of brain IL-6 and induction of Nox2 described above led to increased Nox2-dependent superoxide production in vivo, we assessed superoxide levels using confocal imaging of dihydroethidium (DHE) oxidation to its fluorescent product (ox-DHE) in fixed brain slices prepared from DHE-injected young mice, and from DHE-injected old mice that had been treated for 7 days prior to DHE with either no drug, or with the NADPH oxidase inhibitor, apocynin, in their drinking water.
Negative_regulation (inhibitor) of NADPH in brain associated with imagery
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.09
The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment.
Neg (unaffected) Negative_regulation (unaffected) of NADPH dehydrogenase associated with morphine
4) Confidence 0.05 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.15
Perhaps the most novel finding from our study was that NADPH oxidase inhibition with apocynin mitigated lethal toxin-induced cardiomyocyte contractile dysfunction, intracellular Ca2+ mishandling, intracellular superoxide generation, cell death as well as change in Ca2+ regulatory proteins SERCA2a and phospholamban.
Negative_regulation (inhibition) of NADPH in cardiomyocyte associated with death
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.82 Pain Relevance 0.06
However, a disruption of oxidative damage through the sustained inhibition of the NADPH oxidase could possibly lead to an attenuation of the neuronal cell loss induced by fibrillar A?
Negative_regulation (inhibition) of NADPH in neuronal
6) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.61 Pain Relevance 0.04
The elimination of beta-amyloid-induced oxidative damage through the inhibition of the NADPH oxidase represents an attractive therapeutic target for the treatment of Alzheimer's disease.



Negative_regulation (inhibition) of NADPH associated with alzheimer's dementia and disease
7) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1637099 Disease Relevance 0.70 Pain Relevance 0
Despite ample evidence supporting microglial NADPH oxidase participation in fA?
Negative_regulation (supporting) of NADPH
8) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.50 Pain Relevance 0
Lethal toxin-treated cardiomyocytes (with or without the NADPH oxidase inhibitor apocynin) were plated in microtiter plate at a density of 3×105 cells/ml.
Neg (without) Negative_regulation (inhibitor) of NADPH in cardiomyocytes
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0 Pain Relevance 0
Interestingly, NADPH oxidase inhibition ablated in vitro lethal toxin exposure-induced inhibition in PS and ± dL/dt as well as prolongation of TR90 without affecting lethal toxin-elicited action on resting cell length and TPS (Fig. 5).
Negative_regulation (inhibition) of NADPH
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.07 Pain Relevance 0
Anti-inflammatory drugs suppress injury-induced NADPH-d activity in CA1 pyramidal neurones.
Negative_regulation (suppress) of NADPH-d associated with inflammation, injury and cinod
11) Confidence 0.01 Published 1994 Journal Neuroreport Section Title Doc Link 7827327 Disease Relevance 0.38 Pain Relevance 0.28

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