INT46168

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 8.02
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sepp1) growth (Sepp1) extracellular region (Sepp1)
Anatomy Link Frequency
neural 2
frontal cortex 1
Sepp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 395 99.84 Very High Very High Very High
anesthesia 1 99.28 Very High Very High Very High
Migraine 155 98.64 Very High Very High Very High
Nerve growth factor 116 97.64 Very High Very High Very High
cINOD 105 97.52 Very High Very High Very High
central sensitization 50 97.28 Very High Very High Very High
Pain 33 96.32 Very High Very High Very High
Spinal cord 2 93.36 High High
Pain matrix 5 92.64 High High
Analgesic 22 91.92 High High
Disease Link Frequency Relevance Heat
Headache 485 99.84 Very High Very High Very High
Multiple Sclerosis 4 98.60 Very High Very High Very High
Nociception 27 98.48 Very High Very High Very High
Urological Neuroanatomy 15 98.42 Very High Very High Very High
Headache Disorders 25 97.84 Very High Very High Very High
Anxiety Disorder 21 97.20 Very High Very High Very High
Congenital Anomalies 6 97.16 Very High Very High Very High
Pain 39 96.32 Very High Very High Very High
Erectile Dysfunction 69 94.48 High High
Dyskinesias 2 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that a single stimulus modality results in different signal characteristics dependent on the recording site supports the view that different neural mechanisms involved in primary processing of somatosensory information are responsible for the generation of the SI-SEP P12 and Vx-SEP P15, respectively.
Positive_regulation (generation) of SI-SEP P12 in neural
1) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15571674 Disease Relevance 0.06 Pain Relevance 0.25
The association of electrophysiological sensitisation, i.e. increased 1st block SEP amplitude, and lack of habituation.in MOH patients overusing NSAIDs is intriguing.
Positive_regulation (increased) of SEP associated with cinod and headache
2) Confidence 0.49 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 0.41 Pain Relevance 1.13
Our finding that the SEP amplitude increase in MOH is proportional to the duration of headache chronification suggests that medication overuse and increased headache frequency promote or reinforce central sensitization, but leaves open the question of the culprit.
Positive_regulation (increase) of SEP associated with central sensitization and headache
3) Confidence 0.49 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.58 Pain Relevance 1.50
The fact that a single stimulus modality results in different signal characteristics dependent on the recording site supports the view that different neural mechanisms involved in primary processing of somatosensory information are responsible for the generation of the SI-SEP P12 and Vx-SEP P15, respectively.
Positive_regulation (generation) of Vx-SEP in neural
4) Confidence 0.44 Published 2004 Journal Brain Res. Section Abstract Doc Link 15571674 Disease Relevance 0.06 Pain Relevance 0.25
Results showed that increasing stimulus intensities led to increased SEP amplitudes, which were paralleled by an increased amount of CS-induced fear-conditioned behaviour.
Positive_regulation (increased) of SEP associated with anxiety disorder
5) Confidence 0.41 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17208658 Disease Relevance 0.27 Pain Relevance 0.18
Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity.
Positive_regulation (Increasing) of SEP
6) Confidence 0.41 Published 1983 Journal Brain Res. Section Abstract Doc Link 6871694 Disease Relevance 0.24 Pain Relevance 0
These results suggest that the dose-dependent decrease of the Vx-SEP amplitude, rather than of the SI-SEP, indicates that the US was experienced as less unpleasant.
Positive_regulation (decrease) of SI-SEP
7) Confidence 0.40 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.25 Pain Relevance 0.06
These results suggest that the dose-dependent decrease of the Vx-SEP amplitude, rather than of the SI-SEP, indicates that the US was experienced as less unpleasant.
Positive_regulation (decrease) of Vx-SEP
8) Confidence 0.40 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.25 Pain Relevance 0.06
These results suggest that the dose-dependent decrease of the Vx-SEP amplitude, rather than of the SI-SEP, indicates that the US was experienced as less unpleasant.
Positive_regulation (decrease) of SI-SEP
9) Confidence 0.40 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861104 Disease Relevance 0.25 Pain Relevance 0.06
The orbito-frontal cortex is thought to modulate habituation mechanisms [45] and orbito-frontal lesions induce SEP sensitization and lack of habituation [46], precisely the two sensory abnormalities we found in patients with MOH.
Positive_regulation (induce) of SEP in frontal cortex associated with congenital anomalies, urological neuroanatomy and headache
10) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.07 Pain Relevance 0.87
Our study shows that sensitization, as reflected by increased initial SEP amplitudes, is common to MOH and migraine attacks, although we did not record MOH patients during an attack.
Positive_regulation (increased) of SEP associated with migraine and headache
11) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.37 Pain Relevance 1.19
Studies in animals [21] and humans [22] show that SEP amplitudes increase when transient intense activation of nociceptive afferents induces central sensitization, as happens in clinical pain conditions including chronic headache.
Positive_regulation (increase) of SEP associated with headache disorders, nociception, pain, central sensitization and headache
12) Confidence 0.33 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.20 Pain Relevance 1.09
Maximum amplitude SEP were reached within 15 min of anesthesia.
Positive_regulation (reached) of SEP associated with anesthesia
13) Confidence 0.26 Published 2003 Journal Neuroreport Section Abstract Doc Link 12634475 Disease Relevance 0.29 Pain Relevance 0.14
A progressive increase of SEP in terms of the relative latency and amplitude was seen at week two and four in the ischemic control rats, suggesting regeneration.
Positive_regulation (increase) of SEP
14) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0.15 Pain Relevance 0.30
Compared to the 10 sham-operated normal control rats, SEP was not elicited among the 30 ischemic rats on day two after ischemic induction or day two after the NSC transplant or NGF administration.
Neg (not) Positive_regulation (elicited) of SEP associated with nerve growth factor
15) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0.17 Pain Relevance 0.33
A subgroup of patients with at least a post-operative tumescence, meaning a post-surgical minimal cavernous innervation damage, reported an increase of 5.9 points on the IIEF–EF and of 69% and 52% on SEP-Q2 and Q3.
Positive_regulation (increase) of SEP-Q2
16) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.40 Pain Relevance 0.05

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