INT46207

Context Info Confidence 0.69 First Reported 1983 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 8 Disease Relevance 3.80 Pain Relevance 3.19

transport (Slc10a2) nucleus (Slc10a2)

Anatomy Link Frequency ileum 1 IBAT 1 brush 1 Slc10a2 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 210 99.56 Bile 371 98.86 sodium channel 42 95.96 opiate 1 76.72 antagonist 1 76.16 Catecholamine 1 71.36 anesthesia 7 5.00 imagery 7 5.00

Disease Link Frequency Relevance Heat Obesity 13 100.00 Cystic Fibrosis 210 99.84 Targeted Disruption 63 99.38 Hypothermia 1 92.12 Lower Respiratory Tract Infection 7 70.44 Congenital Anomalies 1 66.88 Liver Disease 14 47.56 Disease 14 5.00 Sprains And Strains 7 5.00 Dislocations 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This increase in IBAT function was paralleled by increases in IBAT protein concentrations.

Positive_regulation (increases) of IBAT

1) Confidence 0.69 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.64 Pain Relevance 0.61

This increase in IBAT function was paralleled by increases in IBAT protein concentrations.

Positive_regulation (increase) of IBAT

2) Confidence 0.60 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.64 Pain Relevance 0.61

Increased bile acid transport in cftr (-/-) mice is associated with an increase in the abundance of IBAT protein in the brush border membrane.

Positive_regulation (increase) of IBAT in brush associated with bile

3) Confidence 0.50 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.07 Pain Relevance 0.27

An alternative mechanism for the upregulation of IBAT in cystic fibrosis is that CFTR acts as a negative regulator of IBAT, as it does for the epithelial sodium channel [36].

Positive_regulation (upregulation) of IBAT associated with fibrosis, cystic fibrosis and sodium channel

4) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.30 Pain Relevance 0.56

In the ileum, IBAT protein densities and taurocholate uptake rates are elevated in cftr (-/-) mice > cftr (+/-) > wild-type mice.

Positive_regulation (elevated) of IBAT in ileum

5) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.23 Pain Relevance 0.28

IBAT protein was comparably increased.

Positive_regulation (increased) of IBAT

6) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.28 Pain Relevance 0.33

Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.

Positive_regulation (increase) of IBAT associated with targeted disruption

7) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.39 Pain Relevance 0.37

During cold exposure (4 degrees C) NE turnover increased in heart and IBAT to a similar extent in both ob/ob and lean mice, but NE turnover rates in heart, and probably in IBAT as well, remained lower in the obese mice than in the lean despite the gradual development of hypothermia in the ob/ob mice during this period.

Positive_regulation (increased) of IBAT in IBAT associated with hypothermia and obesity

8) Confidence 0.39 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.25 Pain Relevance 0.15

General Comments

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