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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 17.06
Pain Relevance 12.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC)
cell adhesion (TNC)
Anatomy Link Frequency
blood 2
neurons 2
efferent neurons 1
erythrocytes 1
chest 1
TNC (Homo sapiens)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 48 100.00 Very High Very High Very High
gABA 36 100.00 Very High Very High Very High
Multiple sclerosis 24 100.00 Very High Very High Very High
Angina 2 99.54 Very High Very High Very High
Inflammation 136 99.40 Very High Very High Very High
Pain 53 99.28 Very High Very High Very High
Etanercept 3 99.12 Very High Very High Very High
fifth nerve 6 99.08 Very High Very High Very High
rheumatoid arthritis 19 98.84 Very High Very High Very High
antidepressant 14 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 54 100.00 Very High Very High Very High
Demyelinating Disease 25 100.00 Very High Very High Very High
Shock 8 100.00 Very High Very High Very High
Disease 136 99.84 Very High Very High Very High
Arthritis 13 99.64 Very High Very High Very High
Angina 2 99.54 Very High Very High Very High
Mental Disorders 101 99.38 Very High Very High Very High
Cancer 208 99.36 Very High Very High Very High
Reprotox - General 1 10 99.24 Very High Very High Very High
Obesity 2 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that stimulation of the TNC leads to a pronounced increase of facial blood flow.
Positive_regulation (stimulation) of TNC in blood
1) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882801 Disease Relevance 0.68 Pain Relevance 0.88
RESULTS: The combination of hypoxia and interleukin-1beta caused a significant increase in tenascin-C protein and mRNA of synovial fibroblasts.
Positive_regulation (increase) of tenascin-C in fibroblasts
2) Confidence 0.67 Published 2008 Journal Oral Dis Section Body Doc Link 18173448 Disease Relevance 0.15 Pain Relevance 0
In contrast, the combination caused no increase in tenascin-C in disk cells.
Neg (no) Positive_regulation (increase) of tenascin-C
3) Confidence 0.67 Published 2008 Journal Oral Dis Section Body Doc Link 18173448 Disease Relevance 0.15 Pain Relevance 0
It also significantly attenuated the increase of Fos-Ir neurons observed in ipsilateral TNC laminae I-II after formalin injection.
Positive_regulation (increase) of TNC in neurons
4) Confidence 0.49 Published 2003 Journal Pain Section Abstract Doc Link 12507695 Disease Relevance 0.48 Pain Relevance 0.37
Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].
Positive_regulation (activators) of tenascin-C in articular associated with inflammation and arthritis
5) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.58 Pain Relevance 0.48
Therefore, we generated HxB-BR, -SPL, -BS and -SB chimeras, which will be referred to as BR, SPL, BS and SB, respectively.
Positive_regulation (generated) of HxB
6) Confidence 0.45 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.14 Pain Relevance 0.03
For example, a wide range of endogenous TLR activators, including heat shock proteins, HMGB1, host DNA, fibrinogen, FNEDA, and tenascin-C, are observed in synovia of RA patients but not in synovia from normal joints or non-inflamed synovia from osteoarthritis (OA) patients [106–112].
Positive_regulation (activators) of tenascin-C in joints associated with shock, rheumatoid arthritis and osteoarthritis
7) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.19 Pain Relevance 0.25
In a few cases, TN is caused by a primary demyelinating disorder.
Positive_regulation (caused) of TN associated with trigeminal neuralgia and demyelinating disease
8) Confidence 0.40 Published 2006 Journal J Long Term Eff Med Implants Section Abstract Doc Link 16700659 Disease Relevance 1.15 Pain Relevance 1.21
Sixteen patients had typical TN, while six had atypical TN.
Positive_regulation (had) of TN associated with trigeminal neuralgia
9) Confidence 0.40 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 7080803 Disease Relevance 1.96 Pain Relevance 1.64
GP home-visits may increase terminally ill cancer patients' possibility of dying at home [22].
Positive_regulation (increase) of GP associated with cancer
10) Confidence 0.38 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2254378 Disease Relevance 0.19 Pain Relevance 0.28
In some cases the relatives experienced that the nurses were unable to reach the GP by phone, and the relatives saw the home care nurses' frustration.
Neg (unable) Positive_regulation (reach) of GP
11) Confidence 0.35 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2254378 Disease Relevance 0.15 Pain Relevance 0
We conclude that the most likely cause of MS-related TN is a pontine plaque damaging the primary afferents.
Spec (likely) Positive_regulation (cause) of MS-related TN in plaque associated with multiple sclerosis and trigeminal neuralgia
12) Confidence 0.35 Published 2009 Journal Pain Section Abstract Doc Link 19171430 Disease Relevance 1.90 Pain Relevance 1.75
Reasons for consulting a GP: ‘a last resort’
Positive_regulation (consulting) of GP
13) Confidence 0.28 Published 2008 Journal Family Practice Section Body Doc Link PMC2440493 Disease Relevance 0.11 Pain Relevance 0.05
After randomisation, 41 intervention patients were offered two extra consultations with and increased accessibility to their GP and 50 control patients received no extra follow-up.
Positive_regulation (increased) of GP
14) Confidence 0.27 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1435903 Disease Relevance 0.36 Pain Relevance 0
CLINICAL PRESENTATION: All three patients had Type-1 TN with spontaneous onset, paroxysm-triggered pain, and response to antiepileptic medication.
Positive_regulation (had) of TN
15) Confidence 0.25 Published 2008 Journal Neurosurgery Section Body Doc Link 18496167 Disease Relevance 0 Pain Relevance 0
Further work-up revealed that the Tn I levels were spuriously elevated because the patient's blood revealed a normal cTnI level when mixed with polyethylene glycol to inactivate any antibodies interfering with the cTnI assay.
Positive_regulation (elevated) of Tn I in blood
16) Confidence 0.21 Published 2007 Journal Clin Cardiol Section Abstract Doc Link 17326064 Disease Relevance 0.89 Pain Relevance 0.16
We examine the case of a 48-year-old man with a history of hypercholesterolemia and obesity who presented with chest pain and was found to have elevated Tn I levels on two separate occasions.
Positive_regulation (elevated) of Tn I in chest associated with angina, obesity and hyperlipidemia
17) Confidence 0.21 Published 2007 Journal Clin Cardiol Section Abstract Doc Link 17326064 Disease Relevance 0.93 Pain Relevance 0.17
Being able to rely on a rapid response from the Mental Health Service in a crisis situation increases the GP's perception of being able to solve problems in a satisfactory manner [18].
Positive_regulation (increases) of GP associated with mental disorders
18) Confidence 0.21 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1933537 Disease Relevance 0.44 Pain Relevance 0
For example, Maxwell [15] notes in passing that two women in her study were reluctant to talk to their usual GPs about their emotional distress in case it influenced their GPs' perceptions of them; one did not want to be judged by her GP (who had seen her throughout her recent pregnancy) while the other perceived her GP to be a 'friend of the family'.
Positive_regulation (perceived) of GP
19) Confidence 0.15 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1941733 Disease Relevance 0.22 Pain Relevance 0.04
DISCUSSION: Although it is uncertain whether the occurrence of TN in our patients may be attributed to the brainstem abnormalities seen on MRI, the presence of these lesions appears to be the most convincing explanation for the occurrence of pain.
Positive_regulation (occurrence) of TN in brainstem
20) Confidence 0.14 Published 2008 Journal Acta Neurochir (Wien) Section Body Doc Link 18958387 Disease Relevance 0.08 Pain Relevance 0

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