INT46886

Context Info Confidence 0.69 First Reported 1982 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 5.29 Pain Relevance 5.90

mitochondrion (Maoa) oxidoreductase activity (Maoa)

Anatomy Link Frequency brain 4 neurons 1 platelet 1 Maoa (Mus musculus)

Pain Link Frequency Relevance Heat monoamine 82 100.00 Serotonin 54 100.00 depression 12 99.70 antidepressant 30 99.58 gABA 11 99.34 agonist 20 99.26 Clonidine 18 99.24 Dopamine 10 98.32 noradrenaline 1 97.80 Neurotransmitter 4 95.24

Disease Link Frequency Relevance Heat Nicotine Addiction 513 100.00 Depression 13 99.70 Stress 3 98.36 Death 3 96.04 Convulsion 6 95.64 INFLAMMATION 3 85.76 Depressive Disorder 2 73.20 Handedness 12 64.16 Affective Disorder 1 57.04 Lung Cancer 9 56.08

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Brain concentrations of gamma-aminobutyric acid (GABA) were significantly reduced and monoamine oxidase (MAO) activity significantly increased in these animals relative to controls.

Positive_regulation (increased) of MAO in Brain associated with gaba and monoamine

1) Confidence 0.69 Published 1982 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7143555 Disease Relevance 0.27 Pain Relevance 0.41

Brain concentrations of gamma-aminobutyric acid (GABA) were significantly reduced and monoamine oxidase (MAO) activity significantly increased in these animals relative to controls.

Positive_regulation (increased) of monoamine oxidase in Brain associated with gaba and monoamine

2) Confidence 0.69 Published 1982 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7143555 Disease Relevance 0.27 Pain Relevance 0.41

The present study shows that MAO activity was inhibited during smoking and restored after quitting, whereas MAO protein concentration was increased during smoking and remained high for many years after quitting.

Positive_regulation (increased) of MAO protein associated with nicotine addiction

3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.27 Pain Relevance 0.04

The largest increase in monoamine oxidase activity was observed with serotonin as substrate (50%).

Positive_regulation (increase) of monoamine oxidase associated with serotonin and monoamine

4) Confidence 0.63 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.99

These results suggest that TEPC possesses potent antidepressant properties that are mediated via MAO activity, HPA axis action and oxidative stress in the FST in mice.

Positive_regulation (mediated) of MAO associated with stress and antidepressant

5) Confidence 0.50 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15619564 Disease Relevance 0.19 Pain Relevance 0.40

The present study shows that MAO activity was inhibited during smoking and restored after quitting, whereas MAO protein concentration was increased during smoking and remained high for many years after quitting.

Positive_regulation (restored) of MAO associated with nicotine addiction

6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.28 Pain Relevance 0.04

Clonidine, unlike diazepam, also inhibited the increase in brain MAO activity.

Positive_regulation (increase) of MAO in brain associated with clonidine

7) Confidence 0.47 Published 1982 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7143555 Disease Relevance 0.23 Pain Relevance 0.42

Monoamines are inactivated by the enzyme, monoamine oxidase.

Positive_regulation (inactivated) of monoamine oxidase associated with monoamine

8) Confidence 0.45 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.54

A marked insulin release following the injection of a maximal dose of the beta 2-adrenoceptor agonist, terbutaline, was accompanied by an increase (30-50%) in islet monoamine oxidase activity.

Positive_regulation (increase) of islet monoamine oxidase associated with agonist and monoamine

9) Confidence 0.45 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.99

In addition, the platelet MAO protein concentration was elevated in FS and also in S.

Positive_regulation (elevated) of MAO protein in platelet associated with nicotine addiction

10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.13 Pain Relevance 0.03

In the case of depression, the level of monoamine oxidase enzyme in the brain is increased, which in turn reduces the levels of monoamines.[4–5] Advances made in diverse areas of neuroscience suggest that the neurotransmitter system, in addition to the monoamines, contributes to the pathophysiology of depression.

Positive_regulation (increased) of monoamine oxidase enzyme in brain associated with neurotransmitter, depression and monoamine

11) Confidence 0.36 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0.59 Pain Relevance 1.22

These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.

Positive_regulation (required) of monoamine oxidase in neurons associated with serotonin and monoamine

12) Confidence 0.08 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.06 Pain Relevance 0.40

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