INT47207

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Context Info
Confidence 0.52
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 16.11
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
lung 3
sputum 1
goblet cell 1
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 781 100.00 Very High Very High Very High
antagonist 172 99.82 Very High Very High Very High
cytokine 622 99.58 Very High Very High Very High
Paracetamol 7 99.00 Very High Very High Very High
chemokine 126 95.84 Very High Very High Very High
Inflammatory response 43 93.00 High High
fibrosis 15 92.76 High High
Multiple sclerosis 1 82.84 Quite High
Potency 6 80.04 Quite High
withdrawal 10 79.72 Quite High
Disease Link Frequency Relevance Heat
Asthma 2194 100.00 Very High Very High Very High
INFLAMMATION 823 100.00 Very High Very High Very High
Occupational Lung Diseases 137 100.00 Very High Very High Very High
Pneumonia 47 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Eosinophilia 111 99.90 Very High Very High Very High
Rhinitis 84 99.80 Very High Very High Very High
Hepatocellular Cancer 2 99.64 Very High Very High Very High
Hyperplasia 52 99.48 Very High Very High Very High
Hypersensitivity 139 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morrow et al showed an AhR ligand dependent growth inhibition in LNCaP cells.
Negative_regulation (inhibition) of AhR
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.63 Pain Relevance 0
-TrCP mRNA levels, similar to the single knockdown cells; yet as expected, in these cells AhR levels were decreased rather than increased both at the mRNA and protein levels (Figure 5C, D).
Negative_regulation (decreased) of AhR
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0 Pain Relevance 0
However, there was no significant difference, although the sTNFR treated group tended to decrease AHR compared with the OVA group (206.68 ± 27.75 vs. 257.55 ± 62.67, 311.83 ± 45.06 vs. 370.52 ± 66.29, 509.29 ± 85.65 vs. 469.36 ± 75.02, 793.74 ± 164.64 vs. 672.50 ± 115.16, 1162.70 ± 205.22 vs. 884.60 ± 226.76, at the respective concentration of methacholine) (p > 0.05).


Negative_regulation (decrease) of AHR
3) Confidence 0.43 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.27 Pain Relevance 0.15
A previous study showed that in murine hepatoma cells, estradiol suppressed the AhR–DRE pathway triggered by dioxin through AhR but not through the ER (Jeong and Lee 1998).
Negative_regulation (suppressed) of AhR associated with hepatocellular cancer
4) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.27 Pain Relevance 0.04
As a result, AhR mRNA was decreased about 30% in N2a-R?
Negative_regulation (decreased) of AhR
5) Confidence 0.41 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
This is based on the finding that the increase of CYP1A1 mRNA expression caused by over-expression of exogenous AhR was clearly suppressed by repression of the AhR with siRNA.
Negative_regulation (repression) of AhR associated with repression
6) Confidence 0.41 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.44 Pain Relevance 0.03
, such as CYP1A1, this expression would be attenuated by suppressing AhR activity.
Negative_regulation (suppressing) of AhR
7) Confidence 0.41 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
AhR depletion reversed the growth suppression effect of ?
Negative_regulation (depletion) of AhR
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.56 Pain Relevance 0.04
Maximum decrease in hepatic AHH activity occurred in all age groups at 10 hr post-AAP administration, and had not returned to control values 24 hr after treatment.
Negative_regulation (decrease) of AHH associated with paracetamol
9) Confidence 0.38 Published 1981 Journal Drug Chem Toxicol Section Abstract Doc Link 7261945 Disease Relevance 0 Pain Relevance 0.61
Using an alternative experimental approach, Peebles et al. [26] showed an IL-13-dependent increased AHR under COX-2 inhibition in OVA-sensitized mice.
Negative_regulation (inhibition) of AHR associated with asthma
10) Confidence 0.33 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.57 Pain Relevance 0.05
blocking therapy inhibits airway inflammation and airway hyperresponsiveness (AHR) in a mouse model of asthma.
Negative_regulation (inhibits) of AHR associated with asthma and inflammation
11) Confidence 0.32 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2730622 Disease Relevance 0.98 Pain Relevance 0.18
Contrary to expectation, our result didn't show a significant decrease of AHR after sTNFR treatment.
Negative_regulation (decrease) of AHR
12) Confidence 0.32 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.94 Pain Relevance 0.16
Therefore, COX-2 products appear to limit the HDM-induced AHR and play a protective role at the airway functional level.
Negative_regulation (limit) of AHR associated with asthma
13) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.49 Pain Relevance 0.03
blocking therapy inhibits the airway inflammation and AHR in murine asthma model.
Negative_regulation (inhibits) of AHR associated with asthma and inflammation
14) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.80 Pain Relevance 0.21
These results suggest that enhanced SP-D production in the lung of C57BL/6 mice may contribute to an attenuated AHR in response to allergic airway sensitization.
Negative_regulation (attenuated) of AHR in lung associated with hypersensitivity
15) Confidence 0.27 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.14 Pain Relevance 0.06
The sputum group had lowered AHR, fewer exacerbations, lower prednisone doses, and fewer admissions to hospital while receiving the same inhaled steroid dose.
Negative_regulation (lowered) of AHR in sputum associated with occupational lung diseases
16) Confidence 0.24 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.77 Pain Relevance 0.11
induced AHR was inhibited demonstrating a critical role for FBLN-1 in the mechanism of TGF?
Negative_regulation (inhibited) of AHR
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.60 Pain Relevance 0.08
mg/kg) and CsA have inhibitory effects on AHR.
Negative_regulation (effects) of AHR
18) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.06
Notably, this is, to our knowledge, the first report demonstrating that inhibition of a matrix protein reduces AHR, thereby providing direct evidence for the role of the ECM in regulating AHR in this model.
Negative_regulation (reduces) of AHR
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.60 Pain Relevance 0.11
Mice with deficient TH2 cytokine expression, induced by gene deletion or the usage of TH2 cytokine antagonists, showed diminished AHR and eosinophilic inflammation [9, 11].
Negative_regulation (diminished) of AHR associated with rhinitis, inflammation, antagonist and cytokine
20) Confidence 0.17 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.53 Pain Relevance 0.29

General Comments

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