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Context Info
Confidence 0.56
First Reported 1981
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.64
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
brain 1
epithelial cell 1
vesicle 1
ears 1
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 13 100.00 Very High Very High Very High
aspirin 4 99.46 Very High Very High Very High
Inflammation 50 99.04 Very High Very High Very High
Enkephalin 1 97.44 Very High Very High Very High
Opioid 1 96.84 Very High Very High Very High
Neurotransmitter 2 96.24 Very High Very High Very High
Pain 3 95.00 High High
lidocaine 1 93.92 High High
antagonist 1 92.92 High High
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 68 100.00 Very High Very High Very High
Pain 3 95.00 High High
Stress 5 94.36 High High
Neurodegenerative Disease 3 91.92 High High
Adhesions 1 88.30 High High
Apoptosis 5 86.32 High High
Alzheimer's Dementia 2 78.00 Quite High
Cancer 13 75.00 Quite High
Disease 5 71.84 Quite High
Overactive Bladder 61 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of some steroidal & non-steroidal anti-inflammatory drugs on purified goat brain cathepsin L.
Regulation (Effect) of cathepsin L in brain associated with inflammation and cinod
1) Confidence 0.56 Published 1993 Journal Indian J. Med. Res. Section Title Doc Link 8262580 Disease Relevance 0.45 Pain Relevance 0.40
In contrast, cathepsin L activity was not affected at all by steroidal anti-inflammatory agents.
Neg (not) Regulation (affected) of cathepsin L associated with inflammation
2) Confidence 0.56 Published 1993 Journal Indian J. Med. Res. Section Abstract Doc Link 8262580 Disease Relevance 0.41 Pain Relevance 0.37
Aspirin was also found to have no effect on cathepsin L activity whereas salicylic acid, its m- and p-analogs exhibited inhibitory effects but to a lesser degree.
Neg (no) Regulation (effect) of cathepsin L associated with aspirin
3) Confidence 0.56 Published 1993 Journal Indian J. Med. Res. Section Abstract Doc Link 8262580 Disease Relevance 0.40 Pain Relevance 0.36
Of these agents, only fluocinolone acetonide affects MEP levels by suppressing the basal level of MEP synthesis but not its relative induction by TPA.
Neg (not) Regulation (affects) of MEP
4) Confidence 0.53 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.14 Pain Relevance 0.14
Inhibitory effects of certain commonly used anti-inflammatory drugs were observed on lysosomal thiol proteinase cathepsin L.
Regulation (effects) of cathepsin L associated with inflammation and cinod
5) Confidence 0.36 Published 1993 Journal Indian J. Med. Res. Section Abstract Doc Link 8262580 Disease Relevance 0.43 Pain Relevance 0.38
RESULTS: There was significant reduction of the MIP MEP and PEF values at 24 and 48 hours post-operative compared to the pre-operative values.
Regulation (values) of MEP
6) Confidence 0.26 Published 2009 Journal Acta Gastroenterol. Latinoam. Section Body Doc Link 19408738 Disease Relevance 0.08 Pain Relevance 0
No significant difference was found between the MEP values of the two groups before the anesthesia (p>0.05), and MEP values measured during the anesthesia were significantly higher in group II (p=0.007).
Regulation (values) of MEP
7) Confidence 0.23 Published 2006 Journal Int. J. Pediatr. Otorhinolaryngol. Section Body Doc Link 16466811 Disease Relevance 0 Pain Relevance 0
RESULTS: Mean MEP values in 26 ears of 13 boys in group I did not show any significant difference before and after the anesthesia with propofol (p>0.05).
Regulation (values) of MEP in ears
8) Confidence 0.23 Published 2006 Journal Int. J. Pediatr. Otorhinolaryngol. Section Body Doc Link 16466811 Disease Relevance 0 Pain Relevance 0
Table 3 summarizes the isolated transcripts that in general are involved in: actin dynamics (wdr1); apoptosis (sirt1, siva, and bcap31); calcium ion binding (pls3, sc1, scp-1, sparc, and smoc2); cell adhesion (col3a1 and catenin); cell cycle/ G-protein coupled receptor (cam2); cell growth (prss11); cell motility (actr3); cytoskeleton organization and biogenesis (actg1, actg2, and mylc2b);defense response (ly6d); electron transport (cox7b, grp58, and coxI); epithelial cell proliferation (grn); immune response (ifit3); insulin processing (cpe); iron ion transport (fth1); metabolism/ glutathione transferase activity (gsto1, gsta4, and gstm1); negative regulation of translational initiation (eif4ebp2); nuclear mRNA splicing (sfsc35 and sfrs6); phospholipid biosynthesis (gpam); positive regulation of transcription (mafb); post-embryonic development (sepp1); protein biosynthesis (rps7 and rps21); protein folding (dnaJ); protein ubiquitination (zfp364); proteolysis (ctse, ctsh, ctsl, Aplp2, serpina3n, and tmprss2); regulation of cell shape (sprr2A); regulation of muscle contraction (my19 and cnn1); response to oxidative stress (prdx1 and prnp); synaptic transmission (syn1); and tRNA aminoacylation (lamp2).


Regulation (regulation) of ctsl in epithelial cell associated with stress, apoptosis and adhesions
9) Confidence 0.09 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.32 Pain Relevance 0
Secretory vesicle cathepsin L participates in the proteolytic conversion of proenkephalin into the active enkephalin, an opioid peptide neurotransmitter that mediates pain relief.
Regulation (participates) of cathepsin L in vesicle associated with pain, neurotransmitter, enkephalin and opioid
10) Confidence 0.05 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 17081116 Disease Relevance 0.41 Pain Relevance 0.38

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