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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 101
Total Number 104
Disease Relevance 45.27
Pain Relevance 24.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
muscle 7
LES 3
chest 2
fissure 2
elbow 2
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Botox 111 100.00 Very High Very High Very High
Gabapentin 7 99.92 Very High Very High Very High
headache 122 99.90 Very High Very High Very High
Pain 169 99.88 Very High Very High Very High
Migraine 146 99.84 Very High Very High Very High
tetrodotoxin 2 99.80 Very High Very High Very High
intrathecal 1 99.78 Very High Very High Very High
Pain management 1 99.62 Very High Very High Very High
trigger zone 1 99.52 Very High Very High Very High
fibrosis 6 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tremor 24 100.00 Very High Very High Very High
Strabismus 10 100.00 Very High Very High Very High
Pain 101 99.88 Very High Very High Very High
Voice Disorders 6 99.88 Very High Very High Very High
Sprains And Strains 4 99.88 Very High Very High Very High
Esophageal Motility Disorder 15 99.86 Very High Very High Very High
Headache 214 99.84 Very High Very High Very High
Clostridium Infection 8 99.84 Very High Very High Very High
Cerebral Palsy 8 99.76 Very High Very High Very High
Stress 94 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether SCI-induced dendritic spine remodeling contributes to neuronal hyperexcitability and neuropathic pain, we analyzed spine morphometry, localization, and functional influence in dorsal horn (DH) neurons in adult rats 1 month after sham surgery, contusion SCI, and SCI treated with a selective inhibitor of Rac1 activation, NSC23766.
Gene_expression (activation) of Rac1 in spine associated with frailty, dorsal horn, neuropathic pain, contusions and hyperexcitability
1) Confidence 0.68 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052208 Disease Relevance 1.31 Pain Relevance 0.69
Inhibition of NADPH oxidase by transient transfection of a dominant negative Rac1 mutant (RacN17) plasmid blocked NGF-stimulated TRPV1 protein expression, while expression of a constitutively active Rac1 increased basal and NGF-stimulated TRPV1 levels.
Gene_expression (expression) of Rac1 associated with nerve growth factor
2) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.21 Pain Relevance 0.48
NGF stimulated NADPH oxidase activity, while 24 h exposure further increased expression of the Rac1 and gp91(phox) subunits of the holoenzyme.
Gene_expression (expression) of Rac1 associated with nerve growth factor
3) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.24 Pain Relevance 0.46
Rac1 is also expressed in endothelium of vascular cells, and targeted deletion of endothelial Rac1 has been demonstrated to reduce focal cerebral ischemia-induced edema in mice [28].
Gene_expression (expressed) of Rac1 in endothelium associated with brain hemorrhage, pressure and volume under development and ischemia
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.28 Pain Relevance 0.28
The botulinum toxin A is produced by Clostridium botulinum and causes a reversible, selective muscle relaxation that leads to a temporary flattening of the mechanical component of wrinkling without the stigmata of invasive surgery.
Gene_expression (produced) of botulinum toxin in stigmata associated with wrinkles and clostridium infection
5) Confidence 0.61 Published 2004 Journal Aesthetic Plast Surg Section Abstract Doc Link 15580431 Disease Relevance 0.19 Pain Relevance 0
Unusual neurotoxigenic Clostridium butyricum strains that produced botulinum-like toxin type E were isolated from the feces of the patients.
Gene_expression (produced) of botulinum-like toxin in feces associated with sprains and strains
6) Confidence 0.59 Published 1999 Journal Clin. Infect. Dis. Section Abstract Doc Link 10585782 Disease Relevance 0.78 Pain Relevance 0.09
The initial evaluation (history, physical examination, 3-day urinary diary, V8 score, flowmetry and post-void residual) was repeated 6 weeks after botulinum toxin A injection.
Gene_expression (injection) of botulinum toxin
7) Confidence 0.58 Published 2007 Journal J. Urol. Section Body Doc Link 17296399 Disease Relevance 0.08 Pain Relevance 0
Treatment of chest pain in patients with noncardiac, nonreflux, nonachalasia spastic esophageal motor disorders using botulinum toxin injection into the gastroesophageal junction.
Gene_expression (injection) of botulinum toxin in chest associated with angina, spasticity and esophageal motility disorder
8) Confidence 0.58 Published 2002 Journal Am. J. Gastroenterol. Section Title Doc Link 12135012 Disease Relevance 0.30 Pain Relevance 0.19
METHODS: Twenty-nine noncardiac chest pain patients with nonachalasia, nonreflux-related spastic esophageal motility disorders were enrolled in this open label trial of botulinum toxin injection at the gastroesophageal junction.
Gene_expression (injection) of botulinum toxin in chest
9) Confidence 0.58 Published 2002 Journal Am. J. Gastroenterol. Section Body Doc Link 12135012 Disease Relevance 0.28 Pain Relevance 0
We investigated the efficacy of an eutectic mixture of local anesthetics (EMLA) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with botulinum toxin injections received EMLA cream and placebo.
Gene_expression (injection) of botulinum toxin in eyelids associated with pain, hemifacial spasm, dystonia, dyskinesias and local anesthetic
10) Confidence 0.58 Published 2002 Journal Ophthalmologica Section Abstract Doc Link 12424403 Disease Relevance 0.55 Pain Relevance 0.84
RESULTS: : There was significant improvement in patients with acupuncture site-guided botulinum toxin injection.
Gene_expression (injection) of botulinum toxin
11) Confidence 0.58 Published 2003 Journal Dermatol Surg Section Body Doc Link 12828700 Disease Relevance 0.07 Pain Relevance 0
We used easily recognizable acupuncture sites for the injection of botulinum toxin.
Gene_expression (injection) of botulinum toxin
12) Confidence 0.58 Published 2003 Journal Dermatol Surg Section Body Doc Link 12828700 Disease Relevance 0.07 Pain Relevance 0
Studies that have primarily used botulinum toxin type A, but with varying dose regimens and sites of administration, have since observed its beneficial effects and in those subjects, headaches have lessened in their frequency or severity.
Gene_expression (used) of botulinum toxin associated with headache and botox
13) Confidence 0.58 Published 2003 Journal Semin Ophthalmol Section Abstract Doc Link 15513006 Disease Relevance 0.55 Pain Relevance 0.58
Botulinum toxin produces a temporary chemical denervation, which initially was used to reduce the diplopia associated with paralytic strabismus.
Gene_expression (produces) of Botulinum toxin associated with diplopia and strabismus
14) Confidence 0.58 Published 2001 Journal Curr Opin Ophthalmol Section Abstract Doc Link 11734681 Disease Relevance 0.64 Pain Relevance 0.21
Randomized prospective controlled trial of lateral internal sphincterotomy versus injection of botulinum toxin for the treatment of idiopathic fissure in ano.
Gene_expression (injection) of botulinum toxin in fissure associated with pain and anal fissure
15) Confidence 0.58 Published 2005 Journal ANZ J Surg Section Title Doc Link 15972045 Disease Relevance 0.20 Pain Relevance 0.15
Current data suggest that botulinum toxin is safe and does not produce systemic effects associated with other types of headache treatments.
Neg (not) Gene_expression (produce) of botulinum toxin associated with headache
16) Confidence 0.58 Published 2002 Journal Clin J Pain Section Abstract Doc Link 12569965 Disease Relevance 1.55 Pain Relevance 1.61
We report our experience with botulinum toxin injections in 108 patients with various central nervous system disorders.
Gene_expression (injections) of botulinum toxin in central nervous system associated with central nervous system
17) Confidence 0.58 Published 1994 Journal Isr. J. Med. Sci. Section Abstract Doc Link 7982770 Disease Relevance 1.16 Pain Relevance 0.18
Although botulinum toxin A was first introduced to treat strabismus and blepherospasm it is now used in an increasing number of conditions, many in the field of pediatrics.
Gene_expression (introduced) of botulinum toxin associated with strabismus
18) Confidence 0.58 Published 1999 Journal Brain Dev. Section Abstract Doc Link 10372898 Disease Relevance 0.18 Pain Relevance 0
Botulinum toxin was introduced as a safe and effective treatment for strabismus and other disorders of the extraocular muscles in the early 1980s.
Gene_expression (introduced) of Botulinum toxin in muscles associated with strabismus
19) Confidence 0.58 Published 1997 Journal Am Fam Physician Section Abstract Doc Link 9054223 Disease Relevance 0.73 Pain Relevance 0
METHODS: We used ethyl chloride medium-stream spray, in conjunction with precooling by frozen ice packs, in our No Sweat Clinic for our most recent 51 consecutive cases of botulinum toxin injection.
Gene_expression (injection) of botulinum toxin in Sweat
20) Confidence 0.58 Published 2009 Journal J Cutan Med Surg Section Body Doc Link 19769833 Disease Relevance 0.09 Pain Relevance 0

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