INT47503

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.96
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (HPS1) cytoplasmic membrane-bounded vesicle (HPS1) lysosome (HPS1)
cytoplasm (HPS1)
HPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 7 99.80 Very High Very High Very High
Catechol-O-methyltransferase 763 99.68 Very High Very High Very High
Pain 134 98.68 Very High Very High Very High
Catecholamine 49 96.88 Very High Very High Very High
tolerance 3 81.80 Quite High
alcohol 130 76.16 Quite High
Fibrositis 14 65.96 Quite High
Opioid 2 51.04 Quite High
addiction 27 50.48 Quite High
Dopamine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hantavirus Infection 601 100.00 Very High Very High Very High
Pain 134 98.68 Very High Very High Very High
Cognitive Disorder 49 97.44 Very High Very High Very High
Polyps 98 96.44 Very High Very High Very High
Colon Cancer 79 94.68 High High
Hyperplasia 15 94.60 High High
Arrhythmias 2 Under Development 1 83.88 Quite High
Adenoma 10 83.36 Quite High
Fatigue 1 80.92 Quite High
Diuresis 2 73.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most studies of HPs in treatment suggest an age for substance related impairment to be middle adulthood and HPs younger than 35 tend to abuse a combination of AOD [33].
Gene_expression (adulthood) of HPs
1) Confidence 0.58 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2265282 Disease Relevance 0.11 Pain Relevance 0.23
Most studies of HPs in treatment suggest an age for substance related impairment to be middle adulthood and HPs younger than 35 tend to abuse a combination of AOD [33].
Gene_expression (adulthood) of HPs
2) Confidence 0.58 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2265282 Disease Relevance 0.10 Pain Relevance 0.21
RE-HPS was present in all patients at S2H2 intervals comparable to control values; however, significantly closer S1S2 intervals were necessary to achieve these requisite S2H2 delays (p < 0.005).
Gene_expression (present) of HPS associated with hantavirus infection
3) Confidence 0.48 Published 1980 Journal Circulation Section Abstract Doc Link 7397979 Disease Relevance 0.78 Pain Relevance 0.57
To test whether minor SNPs linked to APS or HPS haplotypes rescue COMT activity, further reduce it, or produce neutral effects, a series of molecular modeling and cell culture studies were performed.
Gene_expression (haplotypes) of HPS associated with catechol-o-methyltransferase and hantavirus infection
4) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.41 Pain Relevance 0.24
Also consistent with previous studies [37], enzymatic activity corresponding to both the APS and HPS haplotypes was reduced compared to the LPS haplotype (F6,7?
Gene_expression (haplotypes) of HPS associated with hantavirus infection
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.62 Pain Relevance 0.03
A) or HPS (rs6267; 417G?
Gene_expression (417G) of HPS associated with hantavirus infection
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.44 Pain Relevance 0.17
While LPS, APS, and HPS haplotypes of the COMT gene are common in the population, accounting for nearly 96% of all detected haplotypes in the coding region [27], a significant number of less common minor SNPs are also situated in this region.
Gene_expression (haplotypes) of HPS associated with catechol-o-methyltransferase and hantavirus infection
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.98 Pain Relevance 0.59
Tight linkage of these neutral polymorphisms with more recently acquired low activity APS and HPS haplotypes does not satisfy a simple ancestral model and requires the development of a more complex population genetic model to account for pleiotropic selection.
Gene_expression (haplotypes) of HPS associated with hantavirus infection
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.57 Pain Relevance 0.37
Previously constructed full-length cDNA COMT clones that differed only in three nucleotides corresponding to the LPS, APS, and HPS haplotypes were used [37].
Gene_expression (haplotypes) of HPS associated with catechol-o-methyltransferase and hantavirus infection
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.46 Pain Relevance 0.19
Consistent with previous studies [37], protein expression levels exhibited by the APS haplotype did not differ relative to the LPS haplotype, while expression levels displayed by the HPS haplotype were reduced 4.5-fold (F6,7?
Gene_expression (haplotype) of HPS associated with hantavirus infection
10) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.51 Pain Relevance 0.06
As reflected in the WHO criteria, HPS presents with extensive phenotypic heterogeneity not only with respect to the number and size of polyps, but also with regard to presence of CRC, polyp histology, sex ratios, age of onset, and the presence of a family history of CRC [10, 14–22] (Table 1).
Gene_expression (presents) of HPS associated with colon cancer, polyps and hantavirus infection
11) Confidence 0.40 Published 2010 Journal Int J Colorectal Dis Section Body Doc Link PMC2862176 Disease Relevance 1.80 Pain Relevance 0
Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), which is carried by Oligoryzomys longicaudatus, is responsible for most HPS cases in Argentina and Chile.
Gene_expression (cases) of HPS associated with hantavirus infection
12) Confidence 0.37 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2730342 Disease Relevance 1.18 Pain Relevance 0.04

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