INT47514

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Context Info
Confidence 0.61
First Reported 1980
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.43
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Avpr2) signal transducer activity (Avpr2)
Anatomy Link Frequency
inner medulla 1
urine 1
Avpr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 5 99.58 Very High Very High Very High
medulla 1 99.26 Very High Very High Very High
Clonidine 11 95.20 Very High Very High Very High
agonist 3 94.94 High High
sSRI 12 92.84 High High
carbamazepine 44 90.48 High High
Trigeminal neuralgia 8 89.72 High High
headache 12 69.80 Quite High
antagonist 14 66.64 Quite High
Calcium channel 2 64.00 Quite High
Disease Link Frequency Relevance Heat
Hyponatremia 146 99.92 Very High Very High Very High
Syndrome 6 99.64 Very High Very High Very High
Depression 7 99.58 Very High Very High Very High
Chronic Renal Failure 124 99.40 Very High Very High Very High
Diuresis 17 99.14 Very High Very High Very High
Hypothermia 4 99.12 Very High Very High Very High
Diabetes Insipidus 4 98.56 Very High Very High Very High
Headache 20 89.72 High High
Increased Venous Pressure Under Development 11 87.68 High High
Bronchiectasis 10 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH).
Localization (release) of antidiuretic hormone associated with diuresis, hypothermia and depression
1) Confidence 0.61 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597114 Disease Relevance 0.37 Pain Relevance 0.09
Clonidine, an alpha adrenergic agonist which causes a diuresis in experimental animals, was studied in unanesthetized, conscious Brattleboro rats heterozygous or homozygous for hereditary hypothalamic diabetes insipidus to determine if the diuresis was due to alpha adrenergic inhibition of antidiuretic hormone (ADH) release or to another mechanism of action.
Localization (release) of antidiuretic hormone associated with diuresis, diabetes insipidus, agonist and clonidine
2) Confidence 0.42 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.62 Pain Relevance 0.53
This hyporeactivity in vivo was not explained by an anaesthesia-elicited increase in endogenous vasopressin, nor by a modulatory effect linked to V2 receptor activation or prostanoid release.
Localization (release) of V2 receptor
3) Confidence 0.16 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10731046 Disease Relevance 0.64 Pain Relevance 0.06
The clinical challenge of SIADH—three cases

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) remains a challenging disorder to diagnose and treat.

Localization (secretion) of antidiuretic hormone associated with hyponatremia and syndrome
4) Confidence 0.09 Published 2009 Journal NDT Plus Section Title Doc Link PMC2762828 Disease Relevance 1.30 Pain Relevance 0.32
As an extension of these observations, Teitelbaum and McGuinness (24) observed that RT-PCR of total RNA from the inner medulla of CRF rat kidneys revealed virtual absence of V2 receptor mRNA.
Neg (absence) Localization (absence) of V2 receptor mRNA in inner medulla associated with medulla and chronic renal failure
5) Confidence 0.08 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.78 Pain Relevance 0.05
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is one of the more common causes of hyponatraemia and is characterized by an inability to dilute urine despite hypoosmolality [1].
Localization (secretion) of antidiuretic hormone in urine associated with hyponatremia and syndrome
6) Confidence 0.08 Published 2009 Journal NDT Plus Section Body Doc Link PMC2762828 Disease Relevance 0.60 Pain Relevance 0.12
Identification of the human, rat and mouse OR, Taste2, Vomeronasal1 and V2R receptors
Localization (Identification) of V2R
7) Confidence 0.07 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2117022 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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