INT47686

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 5.24
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
RVM 7
nerve 2
neurons 2
adult brain 2
brain 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 22 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
trk B 9 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
antidepressant 5 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
amygdala 12 99.64 Very High Very High Very High
Root ganglion neuron 3 99.04 Very High Very High Very High
Rostral ventromedial medulla 16 98.96 Very High Very High Very High
Pain 24 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 13 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 36 99.08 Very High Very High Very High
Ganglion Cysts 37 98.84 Very High Very High Very High
Pain 16 98.36 Very High Very High Very High
Urological Neuroanatomy 3 95.04 Very High Very High Very High
Dyspepsia 8 89.24 High High
Stress 6 88.04 High High
Nociception 5 87.08 High High
Shock 1 61.28 Quite High
INFLAMMATION 7 41.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study aimed to investigate changes in the expression of BDNF and its receptor tyrosine kinase receptor B (TrkB) in the amygdala and the rostral ventromedial medulla (RVM) after NMS and colorectal distention (CRD) stimulation in rats.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of tyrosine kinase receptor B in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
1) Confidence 0.44 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.06 Pain Relevance 0.52
Furthermore, a significant interactive effect of NMS and CRD on the colocalization coefficient of TrkB and phospho-extracellular signal-regulated kinase expression in both the amygdala and RVM were found.
Regulation (regulated) of Gene_expression (expression) of TrkB in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
2) Confidence 0.44 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 0.97 Pain Relevance 0.68
The present study aimed to investigate changes in the expression of BDNF and its receptor tyrosine kinase receptor B (TrkB) in the amygdala and the rostral ventromedial medulla (RVM) after NMS and colorectal distention (CRD) stimulation in rats.
Spec (investigate) Regulation (changes) of Gene_expression (expression) of TrkB in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
3) Confidence 0.44 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.06 Pain Relevance 0.52
The influence of chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of brain-derived neurotrophic factor (BDNF) and its receptor, trkB, was examined by in situ hybridization and Northern blot.
Spec (examined) Regulation (influence) of Spec (examined) Gene_expression (expression) of trkB in brain associated with antidepressant and convulsion
4) Confidence 0.43 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.81 Pain Relevance 0.15
Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprotachykinin, gamma-preprotachykinin, somatostatin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, galanin, neuropeptide Y and neurotrophin receptor family (trkA, trkB, trkC) genes in dorsal root ganglion neurons by in situ hybridization in adult rats.
Spec (examined) Regulation (effects) of Spec (examined) Gene_expression (expression) of trkB in neurons associated with ganglion cysts, qutenza, root ganglion neuron, neuropeptide, somatostatin and calcitonin gene-related peptide
5) Confidence 0.37 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971780 Disease Relevance 0.17 Pain Relevance 0.79
These changes in the number of Trk B-immunoreactive neurons were observed in both the maxillary and mandibular nerve regions.
Regulation (changes) of Gene_expression (neurons) of Trk B-immunoreactive in nerve associated with trk b
6) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0 Pain Relevance 0.43
Taken together, our data suggest that decreases in TrkB receptor protein at the site of BDNF infusions in the adult brain represent receptor turnover, but this is not associated with altered expression of trkB mRNA or attenuation of the pharmacological effects of BDNF.
Regulation (altered) of Gene_expression (expression) of trkB mRNA in adult brain
7) Confidence 0.27 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.14 Pain Relevance 0.19
Furthermore, a significant interactive effect of NMS and CRD on the colocalization coefficient of TrkB and phospho-extracellular signal-regulated kinase expression in both the amygdala and RVM were found.
Regulation (regulated) of in amygdala Gene_expression (expression) of TrkB in RVM associated with neuroleptic malignant syndrome, amygdala and rostral ventromedial medulla
8) Confidence 0.15 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 0.97 Pain Relevance 0.68
A plausible explanation is that besides direct regulation through GRE binding sites in the 5' regulatory regions of genes, there are changes in expression that are also the indirect results of effects due to changes in expression of transcription factors (TFs) that act as secondary biosignals directly or indirectly modulating the transcription of genes [15,19,20].
Regulation (changes) of Gene_expression (expression) of factors
9) Confidence 0.00 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2973961 Disease Relevance 0.06 Pain Relevance 0.18

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