INT47734

Context Info Confidence 0.56 First Reported 1995 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 19 Total Number 19 Disease Relevance 13.16 Pain Relevance 1.41

nucleus (RAPGEF5) intracellular (RAPGEF5)

Anatomy Link Frequency plasma 1 superior 1 RAPGEF5 (Homo sapiens)

Pain Link Frequency Relevance Heat Catecholamine 3 99.88 adenocard 8 99.30 bradykinin 1 99.08 ischemia 7 97.64 fibrosis 8 92.12 corticosteroid 6 91.28 narcan 7 87.32 Pain 22 85.80 beta blocker 30 85.60 aspirin 16 80.52

Disease Link Frequency Relevance Heat Proteinuria 22 99.96 Disorders Of Creatine Metabolism 54 99.88 Disease 87 99.44 Nicotine Addiction 130 99.32 Renal Disease 300 99.16 Autosomal Dominant Polycystic Kidney 111 98.64 Cv Unclassified Under Development 24 97.64 Renal Failure 34 97.46 Hypertension 176 93.84 Nephrogenic Fibrosing Dermopathy 5 93.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, the cadmium-associated increase in GFR, occurring in the next highest cadmium stratum (0.86 ?

Positive_regulation (increase) of GFR

1) Confidence 0.56 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.38 Pain Relevance 0

HOI caused significant decrements of MAP, PRA, aldosterone, and catecholamines, and increased ANP, GFR, from 94 +/- 5 to 102 +/- 5 ml/min (P < 0.01), ERPF, from 529 +/- 30 to 616 +/- 35 ml/min (P < 0.01), and sodium excretion.

Positive_regulation (increased) of GFR associated with catecholamine

2) Confidence 0.41 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.36 Pain Relevance 0.40

We used the following effect markers: cystatin C in serum (Dharnidharka et al. 2002) for calculation of glomerular filtration rate (GFR), creatinine clearance as markers of glomerular function, and human complex-forming protein (protein HC, ?

Positive_regulation (calculation) of GFR associated with disorders of creatine metabolism

3) Confidence 0.40 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.34 Pain Relevance 0.03

Several studies regarding cystatin C as diagnostic index of renal function in renal transplant patients using Ccr as a reference GFR have been performed, although the accuracy of serum cystatin C and serum creatinine for evaluating GFR differed between the various studies (28).

Positive_regulation (evaluating) of GFR associated with disorders of creatine metabolism and renal failure

4) Confidence 0.35 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.58 Pain Relevance 0.03

In contrast, the prevalence of 1 vessel disease was increased according to increased GFR.

Positive_regulation (increased) of GFR associated with disease

5) Confidence 0.33 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.55 Pain Relevance 0.10

Smokers in this study had a statistically increased GFR compared to non-smokers which is similar to what has been reported for a large population based study from France [36].

Positive_regulation (increased) of GFR associated with nicotine addiction

6) Confidence 0.27 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 1.04 Pain Relevance 0.04

In contrast, the prevalence of 1 vessel disease was increased according to increased GFR.

Positive_regulation (increased) of GFR associated with disease

7) Confidence 0.24 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.55 Pain Relevance 0.10

Outcomes according to the estimated GFR

Positive_regulation (estimated) of GFR

8) Confidence 0.21 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.22 Pain Relevance 0.08

If the GFR is estimated at less than 30 ml.min?

Positive_regulation (estimated) of GFR

9) Confidence 0.18 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 1.13 Pain Relevance 0.20

CONCLUSIONS: Short-term infusion of low to moderate, non-hypertensive doses of vasopressin induced a post-glomerular renal vasoconstriction with a decrease in RBF and an increase in GFR in post-cardiac surgery patients.

Positive_regulation (increase) of GFR

10) Confidence 0.17 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19572935 Disease Relevance 0 Pain Relevance 0

Healthy Caucasian carriers of the A1166C polymorphism showed 7% lower basal GFR and 17% lower basal renal plasma flow, as well as enhanced increases in GFR following treatment with the AT1R blocker losartan [17].

Positive_regulation (increases) of GFR in plasma

11) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.84 Pain Relevance 0

The mean calculated GFR and overall graft survival were also better in the MMF/TAC group.57

Positive_regulation (calculated) of GFR

12) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.33 Pain Relevance 0.09

The simplified MDRD formula has been found to vary most from measured GFR in individuals with normal or near normal renal function, i.e. ?

Positive_regulation (measured) of GFR associated with renal disease

13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.51 Pain Relevance 0

It was postulated that the Trp polymorphism may be associated with increased GFR which balances the increased sodium reabsorption [45].

Positive_regulation (increased) of GFR

14) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.76 Pain Relevance 0

This study corroborates the increase of GFR in children and adolescents with ADPKD and the superior diagnostic performance of Cys C [57].

Positive_regulation (increase) of GFR in superior associated with autosomal dominant polycystic kidney

15) Confidence 0.05 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.83 Pain Relevance 0

More importantly, the mean decrease in the estimated GFR (eGFR) over the 52-week period was less in the benazepril/amlodipine group than in the benazepril/HCTZ group (?

Positive_regulation (estimated) of GFR

16) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.35 Pain Relevance 0

When the normal compensatory mechanisms such as NO, bradykinin, adenosine, and prostaglandins are unable to maintain GFR in the setting of decreased RBF, the groundwork for renal ischemia is laid.

Neg (unable) Positive_regulation (maintain) of GFR associated with adenocard, ischemia and bradykinin

17) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.92 Pain Relevance 0.23

Median GFR was not different between the two treatment groups at baseline (agalsidase alfa: 99 ml/min, range 22 to 136, agalsidase beta: 108, range 53 to 154, p?

Positive_regulation (Median) of GFR

18) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.24 Pain Relevance 0

The placebo-to-active-treatment-cross-over group showed an increase in GFR of 9 ml/min (?

Positive_regulation (increase) of GFR

19) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

This test has worked.