INT47752

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Context Info
Confidence 0.00
First Reported 1995
Last Reported 2005
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.93
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Fam166a) cellular_component (Fam166a) biological_process (Fam166a)
Anatomy Link Frequency
spinal cord 1
SW-480 1
granule cell 1
Fam166a (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 3 99.84 Very High Very High Very High
long-term potentiation 8 99.32 Very High Very High Very High
Spinal cord 4 98.92 Very High Very High Very High
tetrodotoxin 1 96.72 Very High Very High Very High
Hippocampus 3 95.00 High High
Opioid 2 93.04 High High
Dorsal horn neuron 1 91.80 High High
allodynia 3 88.20 High High
IPN 1 87.60 High High
GABAergic 1 80.44 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 6 98.52 Very High Very High Very High
Apoptosis 8 95.32 Very High Very High Very High
Neuropathic Pain 3 88.20 High High
Inflammatory Pain 1 87.60 High High
Alagille Syndrome 3 87.04 High High
Stomach Cancer 1 82.64 Quite High
INFLAMMATION 4 77.40 Quite High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Regulation (determined) of mRNA
1) Confidence 0.00 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.98 Pain Relevance 0.15
There is a fall in prodynorphin mRNA levels with a corresponding increase in proenkephalin mRNA levels.
Regulation (fall) of mRNA
2) Confidence 0.00 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476022 Disease Relevance 0 Pain Relevance 0.24
Reverse transcriptase-PCR analysis showed changes in iNOS mRNA levels that paralleled iNOS protein and NO while indicating a lack of effect of either of the kinase inhibitors on TNFalpha mRNA expression.
Regulation (changes) of mRNA
3) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9464988 Disease Relevance 0.23 Pain Relevance 0.12
This effect is specific for CaMKII alpha mRNA, in that many other mRNA species are not affected, and occurs in the dendritic population of CaMKII alpha mRNA as well as in the pool of mRNA in the granule cell bodies.
Neg (not) Regulation (affected) of mRNA in granule cell
4) Confidence 0.00 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476022 Disease Relevance 0 Pain Relevance 0.27
COX-2 inhibitors do not affect Sp1 or Sp4 mRNA levels in SW-480 cells; however, decreased expression of both proteins was accompanied by increased protein ubiquitination and inhibited by the proteasome inhibitor gliotoxin.
Neg (not) Regulation (affect) of mRNA in SW-480 associated with cox-2 inhibitor
5) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.46 Pain Relevance 0.22
Here we report alterations in CaMKIIalpha mRNA and protein expression in spinal cord tissue from wild-type and heme oxygenase type 2 (HO-2) null mutant mice after formalin injection.
Regulation (alterations) of mRNA in spinal cord associated with spinal cord
6) Confidence 0.00 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15082179 Disease Relevance 0.26 Pain Relevance 0.64
CaMKII-alpha and -beta mRNA and protein levels in layer IVC of area 17 are subject to activity-dependent regulation, with brief periods of monocular deprivation caused by intraocular injections of tetrodotoxin leading to a 30% increase in CaMKII-alpha mRNA and a comparable decrease in CaMKII-beta mRNA in deprived ocular dominance columns, especially of layer IVCbeta.
Regulation (regulation) of mRNA associated with tetrodotoxin
7) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.17

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