INT47780

Context Info Confidence 0.74 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 17 Total Number 17 Disease Relevance 5.37 Pain Relevance 2.13

cell differentiation (CREM) signal transduction (CREM) nucleus (CREM) DNA binding (CREM)

Anatomy Link Frequency blood 2 NG108-15 1 CREM (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 8 99.00 withdrawal 11 98.68 psoriasis 84 98.56 Etanercept 160 94.80 Infliximab 36 93.52 Adalimumab 36 92.92 agonist 2 92.68 tolerance 2 85.88 abatacept 28 69.16 antagonist 1 68.24

Disease Link Frequency Relevance Heat Cardiovascular Disease 69 100.00 Nicotine Addiction 37 100.00 Mycobacterium Infection 255 99.08 Hypertension 38 99.04 Repression 1 98.88 Psoriasis 87 98.56 Diabetes Mellitus 63 95.08 Rheumatoid Arthritis 39 94.48 Polyps 31 87.88 Syndrome 21 85.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The ICER was expressed in US dollar per prevented leprosy case as follows:where ‘I’ denotes intervention and ‘ST’ refers to Standard treatment.

Gene_expression (expressed) of ICER associated with mycobacterium infection

1) Confidence 0.74 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970532 Disease Relevance 0.32 Pain Relevance 0

The ICER is expressed in US dollars saved per one prevented leprosy case.

Gene_expression (expressed) of ICER associated with mycobacterium infection

2) Confidence 0.74 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970532 Disease Relevance 0.38 Pain Relevance 0

The ICER was expressed in US dollars per prevented leprosy case.

Gene_expression (expressed) of ICER associated with mycobacterium infection

3) Confidence 0.57 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2970532 Disease Relevance 0.81 Pain Relevance 0

Two interventions had very acceptable ICER: 1) drug therapy for high blood pressure in hypertensive patients not yet under going treatment with an ICER of I$ 2,908 per DALY saved and an annual reduction of 2.3% of cardiovascular disease burden; and 2) mass media campaign to promote tobacco cessation amongst smokers, with an ICER of I$ 3,186 per DALY saved (0.11% of cardiovascular disease burden).

Gene_expression (promote) of ICER in blood associated with nicotine addiction, cardiovascular disease and hypertension

4) Confidence 0.57 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2970607 Disease Relevance 0.70 Pain Relevance 0

Two interventions had very acceptable ICER: 1) drug therapy for high blood pressure in hypertensive patients not yet under going treatment with an ICER of I$ 2,908 per DALY saved and an annual reduction of 2.3% of cardiovascular disease burden; and 2) mass media campaign to promote tobacco cessation amongst smokers, with an ICER of I$ 3,186 per DALY saved (0.11% of cardiovascular disease burden).

Gene_expression (promote) of ICER in blood associated with nicotine addiction, cardiovascular disease and hypertension

5) Confidence 0.57 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2970607 Disease Relevance 0.71 Pain Relevance 0

Overexpression of either antisense CREM or CREB plasmid rescued morphine-induced inhibition of IL-2 promoter activity and protein production.

Gene_expression (Overexpression) of CREM associated with morphine

6) Confidence 0.42 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.56

The ICER (=?

Gene_expression (The) of ICER

7) Confidence 0.38 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796067 Disease Relevance 0.15 Pain Relevance 0.06

In the CUA, the ICER will be expressed as the incremental cost per QALY.

Gene_expression (expressed) of ICER

8) Confidence 0.29 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2928203 Disease Relevance 0 Pain Relevance 0

In the CEA, the incremental cost-effectiveness ratio (ICER) will be expressed as the incremental costs per point improvement on the Youth Self Report Questionnaire.

Gene_expression (expressed) of ICER

9) Confidence 0.25 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2928203 Disease Relevance 0 Pain Relevance 0

The ICER decreased to £24 000 in patients with severe psoriasis and poor quality of life (PASI >10, DLQI >15).

Gene_expression (decreased) of ICER associated with psoriasis

10) Confidence 0.19 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012556 Disease Relevance 0.34 Pain Relevance 0.42

The assessment group model found for MMT versus no drug therapy that the ICER was pound 13,697/QALY, for BMT versus no drug therapy that the ICER was pound 26,429/QALY and, as with the industry model, in direct comparison, MMT was slightly more effective and less costly than BMT.

Gene_expression (effective) of ICER

11) Confidence 0.14 Published 2007 Journal Health Technol Assess Section Body Doc Link 17313907 Disease Relevance 0 Pain Relevance 0

However, using the yardstick that any intervention whose ICER is in excess of three times the per capita GNP is not cost effective, then adding any of the screening programmes to treatment will not be considered as being cost effective.

Gene_expression (is) of ICER

12) Confidence 0.09 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2850877 Disease Relevance 0.23 Pain Relevance 0

The base-case ICER was found to be around 30 000 pounds (?

Gene_expression (found) of ICER

13) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2838414 Disease Relevance 0.48 Pain Relevance 0.62

These conditions have been shown recently to be due to the expression of an inducible cAMP early repressor (ICER) [1], resulting in a repression of the transcription of the insulin gene, and associated with a diminished level of granuphilin, a Rab27a-dependent protein.

Gene_expression (expression) of early repressor associated with repression

14) Confidence 0.04 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 1.00 Pain Relevance 0

Acceptability curves were used to express the uncertainty in the ICER from the probabilistic sensitivity analyses.

Gene_expression (express) of ICER

15) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587698 Disease Relevance 0 Pain Relevance 0

The 'incremental cost-effectiveness ratio' (ICER) will be expressed as cost differences between groups divided by differences in treatment effects between groups.

Gene_expression (expressed) of ICER

16) Confidence 0.02 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2885321 Disease Relevance 0.23 Pain Relevance 0

To determine whether this withdrawal-induced increase in cAMP modifies gene expression, we studied phosphorylation of the cAMP response element-binding protein (CREB) and expression of the c-fos gene, known to contain a cAMP response element, in NG108-15 cells after abrupt withdrawal from chronic treatment with carbachol.

Gene_expression (expression) of cAMP response element in NG108-15 associated with withdrawal

17) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.47

General Comments

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