INT47839

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Context Info
Confidence 0.79
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
serotonergic neurons 1
brain 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 24 100.00 Very High Very High Very High
Catechol-O-methyltransferase 1 100.00 Very High Very High Very High
monoamine 2 99.54 Very High Very High Very High
Dopamine 23 98.64 Very High Very High Very High
Catecholamine 2 95.92 Very High Very High Very High
dopamine receptor 1 93.92 High High
sSRI 6 92.44 High High
amygdala 1 82.44 Quite High
alcohol 78 80.20 Quite High
Thalamus 1 76.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.96 Very High Very High Very High
Drug Induced Neurotoxicity 1 96.96 Very High Very High Very High
Alcohol Addiction 32 91.20 High High
Cognitive Disorder 8 90.08 High High
Alcoholic Liver Diseases 41 77.28 Quite High
Drug Dependence 3 63.68 Quite High
Flushing 1 37.12 Quite Low
Hepatotoxicity 7 10.32 Low Low
Cirrhosis 37 5.00 Very Low Very Low Very Low
Alcoholic Hepatitis 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, [3H]milnacipran might also bind to other sites, serotonin transporter localized on non-serotonergic neurons or serotonergic neurons insensitive to 5,7-DHT neurotoxicity.
Localization (localized) of serotonin transporter in serotonergic neurons associated with drug induced neurotoxicity and serotonin
1) Confidence 0.79 Published 1994 Journal Brain Res. Section Abstract Doc Link 7704599 Disease Relevance 0.10 Pain Relevance 0.50
Here we report on attempts to demonstrate the presence of the serotonin transporter on microvessels from the porcine brain.
Localization (presence) of serotonin transporter in brain associated with serotonin
2) Confidence 0.45 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7478203 Disease Relevance 0 Pain Relevance 0.09
Measurements of indices of 5-HT release in response to ATD in ‘vulnerable’ rodents, like serotonin transporter knockout animals (Holmes et al. 2003), or females have not been performed.
Localization (release) of serotonin transporter associated with targeted disruption and serotonin
3) Confidence 0.22 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080347 Disease Relevance 0.24 Pain Relevance 0.10
Thus, several genes have been described including monoamine oxidase A (MAOA), the serotonin transporter (HTT), catechol-O-methyltransferase (COMT), the corticotropin releasing hormones receptor 1 gene and the dopamine transporter [8,11,13–15].
Localization (releasing) of serotonin transporter associated with catechol-o-methyltransferase, dopamine, serotonin and monoamine
4) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 0.62 Pain Relevance 0.46

General Comments

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