INT47974

Context Info Confidence 0.49 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 2.38 Pain Relevance 2.69

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA) enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)

Anatomy Link Frequency T98G 2 HL-60 2 NFKBIA (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 17 99.50 Paracetamol 6 99.30 cINOD 2 92.48 Inflammation 16 91.76 cytokine 1 90.72 Analgesic 1 80.08 Osteoarthritis 8 75.40 Pain 3 74.64 rheumatoid arthritis 1 61.36 COX2 1 25.00

Disease Link Frequency Relevance Heat Leukemia 2 96.80 Cancer 2 94.28 INFLAMMATION 16 91.76 Nociception 1 82.08 Disease 5 81.68 Arthritis 2 81.44 Osteoarthritis 8 75.40 Apoptosis 4 75.00 Pain 3 74.64 Increased Venous Pressure Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.

Negative_regulation (blocked) of Protein_catabolism (degradation) of I kappa B alpha associated with qutenza

1) Confidence 0.49 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.75

Western blot analysis of IkappaBalpha protein in the cytoplasm of IL-1beta-stimulated T98G cells and electrophoretic mobility shift assay (EMSA) on corresponding nuclear extracts indicate that acetaminophen (10-1000 microM) dose-dependently inhibits both IkappaBalpha degradation and NF-kappaB nuclear translocation.

Negative_regulation (inhibits) of Protein_catabolism (degradation) of IkappaBalpha in T98G associated with paracetamol

2) Confidence 0.48 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.47

IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.

Negative_regulation (inhibition) of Protein_catabolism (degradation) of IkappaBalpha

3) Confidence 0.41 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0

Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.

Negative_regulation (blocked) of Protein_catabolism (degradation) of I kappa B alpha

4) Confidence 0.39 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.34 Pain Relevance 0.21

Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.

Negative_regulation (suppressed) of Protein_catabolism (degradation) of IkappaBalpha

5) Confidence 0.38 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.17 Pain Relevance 0.39

These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.

Negative_regulation (blocked) of Protein_catabolism (degradation) of IkappaB-alpha

6) Confidence 0.05 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.23 Pain Relevance 0.33

In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.

Negative_regulation (inhibition) of Protein_catabolism (degradation) of IkappaB alpha in HL-60 associated with leukemia and qutenza

7) Confidence 0.01 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.52 Pain Relevance 0.54

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