INT48037

Context Info Confidence 0.44 First Reported 1993 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 8 Total Number 9 Disease Relevance 3.96 Pain Relevance 1.24

extracellular space (Adm) aging (Adm) extracellular region (Adm) response to stress (Adm) cytoplasm (Adm)

Anatomy Link Frequency colon 1 bowel 1 stomach 1 body 1 kidney 1 Adm (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 5 100.00 Calcitonin gene-related peptide 12 99.80 Inflammation 6 98.36 cytokine 4 95.16 ischemia 10 81.76 tetrodotoxin 4 81.40 Somatostatin 8 75.00 anesthesia 4 25.00 Pain scale 1 20.24 Pain 15 8.28

Disease Link Frequency Relevance Heat Pancreatitis 160 100.00 Body Weight 1 100.00 Hypertension 5 99.56 Stress 38 98.96 Inflammatory Bowel Disease 4 98.36 Disease 11 97.60 Systemic Sclerosis 29 97.48 Natriuresis 5 96.48 INFLAMMATION 6 94.76 Sprains And Strains 16 88.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were compared in the rat isolated perfused kidney and in the anaesthetised rat.

Regulation (effects) of adrenomedullin in kidney associated with calcitonin gene-related peptide

1) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498258 Disease Relevance 0.13 Pain Relevance 0.38

In the present study, we have used the isolated, luminally perfused mouse stomach and superfused rat fundic segments to examine the effect of adrenomedullin on exocrine and endocrine secretion in this region of the stomach.

Spec (examine) Regulation (effect) of adrenomedullin in stomach

2) Confidence 0.42 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12573799 Disease Relevance 0 Pain Relevance 0.07

Effects of different doses of clonidine (CAS 4205-90-7) (15, 150, or 300 micrograms/kg body weight) over a period of 3, 14, or 64 days on the activities of delta-aminolevulinic acid synthase (ALA-S) and the P450 dependent isoenzymes aminopyrine-N-demethylase (ADM), 7-ethoxycoumarin-O-deethylase (7-ECO-D), and 7-ethoxyresorufin-O-deethylase (7-ERO-D) as well as on the hepatic porphyrin and P450 content were studied in female rats.

Regulation (Effects) of ADM in body associated with body weight and clonidine

3) Confidence 0.33 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8141818 Disease Relevance 0.24 Pain Relevance 0.30

Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon.

Regulation (Effect) of adrenomedullin in colon

4) Confidence 0.29 Published 1998 Journal Peptides Section Title Doc Link 9700753 Disease Relevance 0 Pain Relevance 0.24

These findings do not support the hypothesis that ADM serves as a modulating factor in hypertension, at least in the SHR.

Regulation (modulating) of ADM associated with hypertension

5) Confidence 0.24 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.35 Pain Relevance 0

N-acetylcysteine seemed to act as a vasodilator, perhaps via modulation of adrenomedullin levels.95 Statins

Regulation (modulation) of adrenomedullin

6) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2860448 Disease Relevance 0.53 Pain Relevance 0

This is in keeping with our results that are the first to show AP-induced disruption of the claudin-1 distribution together with up-regulation of claudin-2, which is also the case in inflammatory bowel disease and destabilizes TJs [7], [10], [40].

Regulation (regulation) of AP in bowel associated with inflammation and pancreatitis

7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 1.44 Pain Relevance 0.25

In addition, the role of oxidative stress has been evaluated in experimental models of acute pancreatitis [43] and it should be emphasized that oxidative stress and excessive ROS generation are early features in AP and consequently a difficult target for clinical prophylaxis to prevent a severe course of the disease.

Regulation (target) of AP associated with stress, pancreatitis and disease

8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 1.27 Pain Relevance 0

Elements for which ADM values were neither practically nor statistically significant or were only practically significant were examined further to determine if appropriate revisions could be made.

Regulation (values) of ADM

9) Confidence 0.01 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1994946 Disease Relevance 0 Pain Relevance 0

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