INT48055

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 27
Total Number 32
Disease Relevance 14.29
Pain Relevance 17.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 7
trigeminal ganglion 2
substantia nigra 2
brain 1
posterior 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 318 100.00 Very High Very High Very High
antagonist 178 100.00 Very High Very High Very High
Glutamate receptor 62 100.00 Very High Very High Very High
Dopamine 27 100.00 Very High Very High Very High
Substantia nigra 10 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
withdrawal 8 99.96 Very High Very High Very High
spinothalamic tract 18 99.84 Very High Very High Very High
Spinothalamic tract neurons 6 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 99.70 Very High Very High Very High
Pain 350 99.68 Very High Very High Very High
Frailty 48 99.56 Very High Very High Very High
Contusions 12 99.42 Very High Very High Very High
Bordatella Infection 2 99.10 Very High Very High Very High
Arthritis 252 98.96 Very High Very High Very High
Hyperalgesia 6 98.80 Very High Very High Very High
Syndrome 6 98.80 Very High Very High Very High
Nervous System Injury 1 98.04 Very High Very High Very High
Neuropathic Pain 12 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that mGluR1 is expressed on neurons that modulate pain transmission and expression on these cells increases following injury, supporting the hypothesis that mGluR1 contributes to CCP following SCI.
Gene_expression (expressed) of mGluR1 in neurons associated with central pain, pain, frailty and injury
1) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.63 Pain Relevance 0.95
Contusion SCI produced an increase in mGluR1 expression on STT cells in both the cervical enlargement and the spinal section just rostral to contusion SCI.
Gene_expression (expression) of mGluR1 in spinal associated with spinothalamic tract, frailty and contusions
2) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.40 Pain Relevance 0.97
The increased expression of mGluR1 parallels the development of thermal hyperalgesia and mechanical allodynia and has been suggested to contribute to the development and maintenance of chronic central pain (CCP) syndromes resulting from SCI.
Gene_expression (expression) of mGluR1 associated with pain, central pain, allodynia, syndrome, thermal hyperalgesia and frailty
3) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.14 Pain Relevance 0.80
Therefore, the expression of mGluR1 on spinothalamic tract (STT) neurons was quantified using confocal imaging and densiometric analysis in normal, sham, and SCI rats.
Gene_expression (expression) of mGluR1 in neurons associated with spinothalamic tract, frailty and imagery
4) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.39 Pain Relevance 0.98
However, expression of mGluR1 has not been directly shown to increase on cells in the pain pathway.
Gene_expression (expression) of mGluR1 associated with pain
5) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.37 Pain Relevance 0.97
Our study demonstrates, for the first time, a coexpression of TRPC1 and mGluR1 receptors in dendrites of the substantia nigra dopaminergic neurons.
Gene_expression (coexpression) of mGluR1 in substantia nigra associated with substantia nigra
6) Confidence 0.73 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.49
Increased expression of metabotropic glutamate receptor subtype 1 on spinothalamic tract neurons following spinal cord injury in the rat.
Gene_expression (expression) of metabotropic glutamate receptor subtype 1 in neurons associated with pain, spinothalamic tract neurons, glutamate receptor and spinal cord
7) Confidence 0.68 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11825670 Disease Relevance 1.28 Pain Relevance 1.23
Presynaptic action potential-dependent action of mGluR1 and postsynaptic action of mGluR5
Gene_expression (action) of mGluR1 associated with action potential
8) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.54 Pain Relevance 0.42
The results obtained with highly selective antagonists for mGluR1 and mGluR5 [40,42,52,53] show that presynaptic mGluR1, but not postsynaptic mGluR5, can account for the pain-related changes of excitatory and inhibitory transmission in CeLC neurons.
Gene_expression (presynaptic) of mGluR1 in neurons associated with pain and antagonist
9) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.57 Pain Relevance 0.78
Confirming the results of our previous study obtained with a different mGluR1 antagonist (CPCCOEt) [20], a selective mGluR1 antagonist (LY367385, 10 ?
Gene_expression (antagonist) of mGluR1 associated with antagonist
10) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.60 Pain Relevance 0.54
Like the mGluR1 antagonist, a selective mGluR5 antagonist (MTEP, 1 ?
Gene_expression (antagonist) of mGluR1 associated with antagonist
11) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.54 Pain Relevance 0.56
The results show that mGluR5 are involved in excitatory and inhibitory synaptic transmission under normal conditions and in the pain state, whereas mGluR1 contribute only to the pain-related changes of excitatory and inhibitory transmission in CeLC neurons.


Gene_expression (contribute) of mGluR1 in neurons associated with pain
12) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.56 Pain Relevance 0.52
Vocalizations were recorded in the same animals before arthritis, 6 h after arthritis induction and during administration of antagonists selective for mGluR1 (CPCCOEt) and mGluR5 (MPEP) into the CeA through stereotaxically implanted microdialysis probes.
Gene_expression (selective) of mGluR1 in CeA associated with antagonist, amygdala and arthritis
13) Confidence 0.57 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 1.04 Pain Relevance 1.16
The mGluR4 mRNA expression was also reduced, but minimum values were found at 4 days of monoarthritis, when no changes could be found in mGluR1 mRNA expression.
Gene_expression (expression) of mGluR1 mRNA
14) Confidence 0.47 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.17 Pain Relevance 0.35
At 2 days of monoarthritis the mGluR1 mRNA expression was decreased mainly in the ventrobasal complex (VB) and in the posterior thalamic nuclei (Po) contralateral to the inflamed joint.
Gene_expression (expression) of mGluR1 mRNA in posterior
15) Confidence 0.47 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.19 Pain Relevance 0.37
The findings showed pronounced enhancements in gene-transcript expression of GluR2, mGluR1, mGluR5, NR1, NR2A, NR2B, EAAT1, and EAAT2-2 in the cortex at bregma +1.6.
Gene_expression (expression) of mGluR1 in cortex
16) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.14 Pain Relevance 0.40
In the hypothalamus, there was a significant increase of GluR1, GluR3, mGluR1, and mGluR3 gene-transcript expressions.


Gene_expression (expressions) of mGluR1 in hypothalamus
17) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.30
On the other hand, a previous western blot analysis revealed the abundant expression of mGluR5 in the trigeminal ganglion but almost no expression of mGluR1, suggesting that the subtype of group I mGluR expressing at central terminals of trigeminal primary afferents in the Vo is exclusively mGluR5 [36].
Neg (no) Gene_expression (expression) of mGluR1 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
18) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.10 Pain Relevance 0.21
Expression of mGluR1 and mGluR5 in the Vo
Gene_expression (Expression) of mGluR1
19) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.05
On the other hand, a previous western blot analysis revealed the abundant expression of mGluR5 in the trigeminal ganglion but almost no expression of mGluR1, suggesting that the subtype of group I mGluR expressing at central terminals of trigeminal primary afferents in the Vo is exclusively mGluR5 [36].
Gene_expression (expressing) of group I mGluR in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
20) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.10 Pain Relevance 0.23

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