INT48198

Context Info Confidence 0.47 First Reported 1993 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 29 Total Number 30 Disease Relevance 19.59 Pain Relevance 2.46

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)

Anatomy Link Frequency spinal cord 1 suture 1 Tgfb1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 266 99.88 Spinal cord 5 99.44 fibrosis 32 98.20 cytokine 86 96.56 chemokine 29 93.20 Angina 1 84.28 Inflammatory response 20 80.40 Neuritis 7 80.20 anesthesia 17 71.76 Peripheral nervous system 1 61.76

Disease Link Frequency Relevance Heat Hypoxia 539 100.00 INFLAMMATION 285 99.88 Targeted Disruption 51 99.76 Injury 72 99.56 Cancer 916 98.40 Sprains And Strains 18 98.24 Pulmonary Fibrosis 4 98.20 Apoptosis 550 98.00 Syndrome 81 97.60 Breast Cancer 266 97.04

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Decorin (DC), a proteoglycan, binds TGF-beta and thereby down-regulates all of its biological activities.

TGF-beta Binding (binds) of

1) Confidence 0.47 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9416971 Disease Relevance 0.26 Pain Relevance 0.20

However, also the presence LTBP3 in this region is of interest, as this protein binds to TGFB1, TGFB2, and TGFB3, and is thus involved in the same signalling pathway as CDKN2B.

TGFB1 Binding (binds) of

2) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.51 Pain Relevance 0

We have demonstrated that modulation of TGF-beta affects calvarial suture formation in vitro and in vivo with TGF-beta antibody and TGF-beta1 antisense plasmid DNA treatment, respectively.

TGF-beta1 Binding (affects) of in suture

3) Confidence 0.30 Published 2001 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 11547147 Disease Relevance 0 Pain Relevance 0.05

In situ hybridization for TGF-beta 1 performed on spinal cord sections 6 days after injection of cells localized TGF-beta 1 mRNA to many nonneuronal cells with the typical morphology of microglia.

TGF-beta 1 Binding (hybridization) of in spinal cord associated with spinal cord

4) Confidence 0.28 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.76 Pain Relevance 0.79

The membranes were incubated with antibodies specific for TGF-?

TGF Binding (specific) of

5) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 0.20 Pain Relevance 0.04

Such data indicate that the RT-induced response in vivo is associated with increased TGF-?

TGF Binding (associated) of

6) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 1.10 Pain Relevance 0.68

exerts on the autoimmune process of SjS, a TSP-1 deficient mouse strain was created; however, the deficient mice presented with less severe inflammation when compared with the TGF-?

TGF Binding (compared) of associated with inflammation, syndrome and sprains and strains

7) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.98 Pain Relevance 0.12

Four days after the creation of the wounds, immunohistochemical staining for TGF-?

TGF Binding (staining) of associated with injury

8) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.75 Pain Relevance 0.12

These results suggest that crosstalk between the hypoxia and TGF-?

TGF Binding (crosstalk) of associated with hypoxia

9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.54 Pain Relevance 0

We investigated interactions between the hypoxia and TGF-?

TGF Binding (interactions) of associated with hypoxia

10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.58 Pain Relevance 0

and hypoxia, suggesting limited crosstalk between TGF-?

TGF Binding (crosstalk) of associated with hypoxia

11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.54 Pain Relevance 0

The aim of these studies was to determine whether TGF?

TGF Spec (determine) Binding (determine) of

12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.36 Pain Relevance 0

A literature search for bone metastatic genes combined with the keywords hypoxia or TGF-?

TGF Binding (combined) of associated with hypoxia

13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.69 Pain Relevance 0

binds to the TGF-?

TGF Binding (binds) of

14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.30 Pain Relevance 0

VEGF, but not CXCR4, mRNA was additively increased by combined treatment with TGF-?

TGF Binding (treatment) of

15) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.19 Pain Relevance 0

This indicates that interaction with TGF-?

TGF Binding (interaction) of

16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.68 Pain Relevance 0

In contrast, patients with TVD had more CD105/TGFbeta1 complex in their sera than the other two groups, suggesting that this may be the reason why TVD patients had low levels of receptor and ligand.

TGFbeta1 Binding (complex) of

17) Confidence 0.05 Published 2000 Journal Atherosclerosis Section Abstract Doc Link 10996361 Disease Relevance 0.29 Pain Relevance 0.08

We further investigated whether TGF-?

TGF Binding (investigated) of

18) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.24 Pain Relevance 0

In control experiments, we found the TGF-?

TGF Binding (found) of

19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.78 Pain Relevance 0

Atorvastatin increased Smad3 phosphorylation associated to elevated PAI-1 expression, collagen deposition and SMA staining, indicating that the TGF-?

TGF Binding (indicating) of

20) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.56 Pain Relevance 0.03

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