INT48216

Context Info Confidence 0.58 First Reported 1994 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.89 Pain Relevance 0.34

cell differentiation (Mak)

Anatomy Link Frequency male germ cell 2 Mak (Rattus norvegicus)

Pain Link Frequency Relevance Heat chemokine 8 72.40 cytokine 14 71.20 adenocard 6 66.80 pain flank 1 65.40 metalloproteinase 12 60.92 Dismenorea 4 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Renal Cancer 10 99.52 Cancer 4 98.34 Transitional Cell Carcinoma 9 92.80 Malignant Neoplastic Disease 1 76.08 Nicotine Addiction 1 73.84 Bladder Cancer 1 71.76 Metastasis 1 68.44 Flank Pain 1 65.40 Hematuria 1 64.68 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

down regulated the expression of serum glucocorticoid kinase (SGK), casein kinase I, extracellular signal-regulated kinase (ERK-1), male germ cell-associated kinase (MAK), and Wee tyrosine kinase.

Gene_expression (expression) of MAK in male germ cell

1) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.14

down regulated the expression of serum glucocorticoid kinase (SGK), casein kinase I, extracellular signal-regulated kinase (ERK-1), male germ cell-associated kinase (MAK), and Wee tyrosine kinase.

Gene_expression (expression) of cell-associated kinase in male germ cell

2) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.14

The tumor tissue infiltrating the lymphatics, which seemed to be RCC, demonstrated positive staining for EMA and keratins CAM-5.2, AE1/AE3, and MAK-6 and negative staining for keratin 34 beta E12.

Gene_expression (staining) of MAK-6 associated with cancer and renal cancer

3) Confidence 0.01 Published 1994 Journal Cancer Section Abstract Doc Link 7506117 Disease Relevance 1.89 Pain Relevance 0.07

General Comments

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