INT48235

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 72
Total Number 73
Disease Relevance 44.54
Pain Relevance 25.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
articular cartilage 3
monocytes 3
synovial fluid 2
chondrocyte 2
cartilage 2
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 767 100.00 Very High Very High Very High
aspirin 10 100.00 Very High Very High Very High
Osteoarthritis 179 99.92 Very High Very High Very High
Dismenorea 1 99.84 Very High Very High Very High
Pain 119 99.82 Very High Very High Very High
cINOD 81 99.54 Very High Very High Very High
Inflammation 212 99.36 Very High Very High Very High
Opioid 4 99.36 Very High Very High Very High
cytokine 117 99.28 Very High Very High Very High
rheumatoid arthritis 138 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 192 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 10 99.84 Very High Very High Very High
Dysmenorrhea 1 99.84 Very High Very High Very High
Canker Sores 1 99.84 Very High Very High Very High
Pain 105 99.82 Very High Very High Very High
Injury 625 99.56 Very High Very High Very High
Apoptosis 51 99.48 Very High Very High Very High
Cancer 287 99.44 Very High Very High Very High
INFLAMMATION 266 99.42 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 5 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bisphosphonates also inhibit cancer cell proliferation, induce apoptosis in in vitro cultures, inhibit angiogenesis, inhibit matrix metalloproteinase, have effects on cytokine and growth factors, and are immunomodulatory.
Negative_regulation (inhibit) of metalloproteinase associated with cancer, metalloproteinase, apoptosis and cytokine
1) Confidence 0.46 Published 2004 Journal J. Vet. Intern. Med. Section Abstract Doc Link 15515572 Disease Relevance 1.22 Pain Relevance 0.18
Analysis of the articular cartilage showed the naproxen was able to significantly suppress the decrease in proteoglycan content and metalloproteinase activities.
Negative_regulation (decrease) of metalloproteinase in articular cartilage associated with metalloproteinase
2) Confidence 0.46 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456630 Disease Relevance 0.16 Pain Relevance 0.22
A number of promising new approaches have been recently tested and brought to trial, including combined antimicrotubular therapy, camptothecins, and matrix metalloproteinase inhibitors.
Negative_regulation (inhibitors) of metalloproteinase associated with metalloproteinase
3) Confidence 0.46 Published 1996 Journal Semin. Oncol. Section Abstract Doc Link 8996586 Disease Relevance 0.47 Pain Relevance 0.14
Marimastat (BB-2516) is the first matrix metalloproteinase inhibitor to have entered clinical trials in the field of oncology.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
4) Confidence 0.29 Published 1999 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 10357560 Disease Relevance 0.12 Pain Relevance 0.17
Marimastat (BB-2516) is the first orally bioavailable matrix metalloproteinase inhibitor to have entered clinical trials in the field of oncology.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
5) Confidence 0.29 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11093361 Disease Relevance 0.27 Pain Relevance 0.21
Marimastat: the clinical development of a matrix metalloproteinase inhibitor.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
6) Confidence 0.29 Published 2000 Journal Expert Opin Investig Drugs Section Title Doc Link 11093361 Disease Relevance 0.62 Pain Relevance 0.23
They found the nanocrystalline silver product promoted rapid wound healing in the first few days post injury and the proteolytic environment of wounds treated with nanocrystalline silver was changed by the reduction of levels of matrix metalloproteinase.
Negative_regulation (reduction) of metalloproteinase associated with injury, wound healing and metalloproteinase
7) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 1.57 Pain Relevance 0.22
However, evidence suggests using Acticoat in wound management is cost effective, reduces wound infection, decreases the frequency of dressing changes and pain levels, decreases matrix metalloproteinase activity, wound exudate and bioburden levels, and promotes wound healing in chronic wounds.
Negative_regulation (decreases) of metalloproteinase associated with pain, wound healing, injury, metalloproteinase and wound infection
8) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2676636 Disease Relevance 1.29 Pain Relevance 0.19
Eight patients completed the study, the authors found a decrease in matrix metalloproteinase activity in the first 2 days of treatment.
Negative_regulation (decrease) of metalloproteinase associated with metalloproteinase
9) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 0.69 Pain Relevance 0.10
Furthermore, when added in vitro to cultures of human articular chondrocytes, nimesulide inhibits the release of stromelysin and blocks metalloproteinase activity.
Negative_regulation (blocks) of metalloproteinase in chondrocytes associated with metalloproteinase
10) Confidence 0.25 Published 1993 Journal Drugs Section Abstract Doc Link 7506193 Disease Relevance 0.14 Pain Relevance 0.30
Inhibition of one of these exopeptidases, cytosol alanine aminopeptidase, results in apoptosis.
Negative_regulation (Inhibition) of cytosol alanine aminopeptidase associated with apoptosis
11) Confidence 0.24 Published 2001 Journal Curr. Drug Metab. Section Abstract Doc Link 11465152 Disease Relevance 0.30 Pain Relevance 0.16
In summary, the literature review of nanocrystalline silver used on humans for wound management suggested nanocrystaline silver is: cost effective, reduces burn wound incidence, decreases pain levels during dressing changes, decreases the frequency of dressing changes, decreases the matrix metalloproteinase activity, reduces the wound exudate and bioburden levels, and promotes wound healing in chronic wounds.
Negative_regulation (decreases) of metalloproteinase associated with pain, burns, wound healing, injury and metalloproteinase
12) Confidence 0.20 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 2.07 Pain Relevance 0.21
Clinical data showed that tissue inhibitor of metalloproteinase and pancreatic secretory trypsin inhibitor in pure pancreatic juice had potential as markers of early-stage pancreatic fibrosis.
Negative_regulation (inhibitor) of metalloproteinase associated with fibrosis and metalloproteinase
13) Confidence 0.16 Published 2007 Journal Rinsho Byori Section Abstract Doc Link 17882797 Disease Relevance 0.74 Pain Relevance 0.80
The addition of other chemotherapies (including other antimetabolites, platinum, and topoisomerase I inhibitors) or targeted therapies (farnesyl transferase inhibitors, metalloproteinase inhibitors, cetuximab and bevacizumab) to gemcitabine has failed to improve outcome.
Negative_regulation (inhibitors) of metalloproteinase associated with metalloproteinase
14) Confidence 0.08 Published 2008 Journal Anticancer Drugs Section Abstract Doc Link 18418211 Disease Relevance 0.49 Pain Relevance 0.14
Metalloproteinase inhibitors
Negative_regulation (inhibitors) of Metalloproteinase associated with metalloproteinase
15) Confidence 0.07 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 1.59 Pain Relevance 0.14
Analysis of the cartilage for matrix metalloproteinase activities showed reduced activity of neutral matrix metalloproteinase by 80%, of collagenase by 40%, and of gelatinase by 87%, with no change in activity of acid metalloproteinase or of tissue inhibitor for metalloproteinase.
Negative_regulation (reduced) of metalloproteinase in cartilage associated with metalloproteinase
16) Confidence 0.06 Published 1993 Journal J. Orthop. Res. Section Abstract Doc Link 8483029 Disease Relevance 0.14 Pain Relevance 0.34
Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation.
Negative_regulation (effect) of metalloproteinase in lung associated with adenocarcinoma, aspirin and metalloproteinase
17) Confidence 0.05 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12044784 Disease Relevance 0.60 Pain Relevance 0.45
Human studies have been conducted with metalloproteinase inhibitors such as batimastat.51 In a phase I study, 22 patients with malignant ascites (16 patients with ovarian cancer, two patients with sarcoma, one patient with breast cancer, one patient with renal carcinoma, one patient with colon cancer, and one patient with endometrial cancer) had batimastat instilled into the peritoneal cavity after paracentesis.
Negative_regulation (inhibitors) of metalloproteinase in peritoneal cavity associated with pressure and volume under development, endometriosis (extended), colon cancer, renal cancer, ovarian cancer, malignant neoplastic disease, sarcoma, metalloproteinase and reprotox - general 1
18) Confidence 0.05 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 1.65 Pain Relevance 0.14
Prolyl hydroxylase and tissue inhibitor of metalloproteinase in pure pancreatic juice in patients with chronic pancreatitis.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase and chronic pancreatitis
19) Confidence 0.05 Published 1998 Journal Pancreas Section Title Doc Link 9598809 Disease Relevance 0.71 Pain Relevance 0.82
Prolyl hydroxylase is a key enzyme in collagen synthesis, and tissue inhibitor of metalloproteinase (TIMP) is known to suppress collagenolytic enzymes.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
20) Confidence 0.05 Published 1998 Journal Pancreas Section Abstract Doc Link 9598809 Disease Relevance 0.54 Pain Relevance 0.59

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