INT48254

Context Info Confidence 0.13 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.09 Pain Relevance 0.29

peptidase activity (Klk1c8)

Anatomy Link Frequency mast cell 1 Klk1c8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 9 93.08 metalloproteinase 20 87.20 chemokine 1 87.12 Inflammation 65 76.16 tolerance 1 64.24 fibrosis 9 54.04 Inflammatory marker 1 52.44 substance P 4 50.00 Chronic pancreatitis 2 47.04 agonist 1 40.08

Disease Link Frequency Relevance Heat Diabetes Mellitus 105 99.56 Myocardial Infarction 6 98.00 Wound Healing 6 93.60 Increased Venous Pressure Under Development 4 93.56 Osteoporosis 6 86.72 Death 2 85.40 Hypersensitivity 1 77.76 Stress 36 77.00 INFLAMMATION 79 76.16 Pharyngitis 1 74.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SP, aprotinin (serine protease inhibitor), and ketotifen (mast cell stabilizer) were infused into the splenic artery of rats.

Negative_regulation (inhibitor) of serine protease in mast cell

1) Confidence 0.13 Published 1994 Journal Gastroenterology Section Body Doc Link 7507874 Disease Relevance 0.09 Pain Relevance 0

Therefore, it is well known that the inhibition of the serine protease DPP-IV in type 2 diabetes treatment prevents its activation of insulin-releasing peptide hormones.

Negative_regulation (inhibition) of serine protease associated with diabetes mellitus

2) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 0.79 Pain Relevance 0.21

Inhibition of the serine protease plasmin appears to have therapeutic advantage in myocardial infarct patients.

Negative_regulation (Inhibition) of serine protease associated with myocardial infarction

3) Confidence 0.02 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.21 Pain Relevance 0.08

General Comments

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