INT48269

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.34
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FANCB) nucleus (FANCB)
Anatomy Link Frequency
7E3 2
platelet 1
FANCB (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 99.96 Very High Very High Very High
Pain 54 96.64 Very High Very High Very High
Angina 7 91.28 High High
agonist 2 90.48 High High
depression 31 88.48 High High
backache 40 80.16 Quite High
psoriasis 1 67.60 Quite High
Multiple sclerosis 10 56.44 Quite High
rheumatoid arthritis 31 35.60 Quite Low
Etanercept 25 31.04 Quite Low
Disease Link Frequency Relevance Heat
Stroke 259 99.92 Very High Very High Very High
Anxiety Disorder 31 99.08 Very High Very High Very High
Thrombosis 2 99.02 Very High Very High Very High
Hemorrhage 8 98.22 Very High Very High Very High
Pain 50 96.64 Very High Very High Very High
Injury 3 94.60 High High
Cv General 3 Under Development 7 91.28 High High
Myocardial Infarction 3 90.52 High High
Depression 31 88.48 High High
Cognitive Disorder 261 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2).
Negative_regulation (impaired) of FAB
1) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.20 Pain Relevance 0
Among the 41 patients with pure cortical infarcts, 21 (51.21%) had impaired MMSE (score < 24) along with impaired FAB.
Negative_regulation (impaired) of FAB
2) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.09 Pain Relevance 0
An additional 14 (23.33%) patients had impaired FAB only; this was as follows: motor series (9 patients), conflicting instructions (7), inhibitory control (6), lexical fluency (9), conceptualization (7), and prehensile behavior (2).
Negative_regulation (impaired) of FAB
3) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.07 Pain Relevance 0
An additional 8 (19.51%) patients had impaired FAB only; this was as follows: motor series (4 patients), conflicting instructions (6), inhibitory control (4), lexical fluency (4), conceptualization (6), and prehensile behavior (3).
Negative_regulation (impaired) of FAB
4) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.09 Pain Relevance 0
When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column.
Negative_regulation (reduced) of Fab
5) Confidence 0.42 Published 1997 Journal Immunol. Invest. Section Abstract Doc Link 9246561 Disease Relevance 0.17 Pain Relevance 0.08
Normal MMSE with impaired FAB was seen in 28 patients.


Negative_regulation (impaired) of FAB
6) Confidence 0.41 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2859587 Disease Relevance 0.71 Pain Relevance 0
This seems to be a direct effect of FAB, since there is no confounding by any other variable.


Negative_regulation (effect) of FAB
7) Confidence 0.40 Published 2007 Journal Spine Section Body Doc Link 17632397 Disease Relevance 0 Pain Relevance 0
In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2).
Negative_regulation (impaired) of FAB
8) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.20 Pain Relevance 0
FAB impairment alone, with MMSE in normal range, was seen in 28/52 (53.8%) patients.
Negative_regulation (impairment) of FAB
9) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2859587 Disease Relevance 0.70 Pain Relevance 0
FAB's are seen to be predictive of outcomes of care where these are measured by disability, but not by severity of pain, [34-39].
Negative_regulation (predictive) of FAB associated with pain
10) Confidence 0.33 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2923166 Disease Relevance 1.40 Pain Relevance 0.61
When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column.
Negative_regulation (unreduced) of Fab
11) Confidence 0.31 Published 1997 Journal Immunol. Invest. Section Abstract Doc Link 9246561 Disease Relevance 0.16 Pain Relevance 0.08
Further studies are underway to develop alternative heparin dosing strategies in an effort to reduce the occurrence of bleeding complications associated with c7E3 Fab administration and to assess the benefit of c7E3 Fab-mediated platelet inhibition in lower risk patient subgroups.
Negative_regulation (inhibition) of Fab-mediated in platelet associated with hemorrhage
12) Confidence 0.20 Published 1994 Journal J Invasive Cardiol Section Abstract Doc Link 10155090 Disease Relevance 0.43 Pain Relevance 0.09
Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding.
Negative_regulation (reduce) of Fab fragment in 7E3 associated with aspirin, hemorrhage and thrombosis
13) Confidence 0.16 Published 1996 Journal Haemostasis Section Abstract Doc Link 8979134 Disease Relevance 0.32 Pain Relevance 0.21
Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding.
Negative_regulation (reduce) of c7E3 Fab in 7E3 associated with aspirin, hemorrhage and thrombosis
14) Confidence 0.14 Published 1996 Journal Haemostasis Section Abstract Doc Link 8979134 Disease Relevance 0.32 Pain Relevance 0.21
During study drug infusion, ischemia occurred in 9 c7E3 Fab and 16 placebo patients (P = .06).
Negative_regulation (occurred) of c7E3 Fab
15) Confidence 0.08 Published 1994 Journal Circulation Section Body Doc Link 7508826 Disease Relevance 0 Pain Relevance 0
inhibitor on a PEGylated Fab fragment (similar to certolizumab) had less placental and milk transfer than a murinzed TNF?
Negative_regulation (inhibitor) of Fab
16) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971732 Disease Relevance 0.48 Pain Relevance 0.11

General Comments

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