INT48292

Context Info Confidence 0.26 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 2.14 Pain Relevance 3.26

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)

Anatomy Link Frequency neurons 5 internal 1 Sh2b2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Action potential 251 100.00 depression 15 99.66 inferior alveolar nerve 1 98.40 trigeminal ganglion 5 98.00 tetrodotoxin 7 96.00 Neuronal excitability 22 94.88 Calcium channel 14 92.68 addiction 3 91.20 Thermal hyperalgesia 1 89.40 qutenza 3 88.24

Disease Link Frequency Relevance Heat Depression 15 99.66 Nociception 9 98.48 Ganglion Cysts 53 98.00 Hyperalgesia 4 89.40 Nervous System Injury 6 79.76 Pain 18 62.64 Infection 95 59.56 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 8 51.44 Dyspepsia 22 50.08 Pseudorabies 5 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At cellular level, eugenol reversibly inhibited APs and VGSCs in IB(4)+/TRPV1+/Na(v)1.8+ nociceptive TG neurons (Type I-Type III) and IB(4)-/TRPV1-/Na(v)1.8- nociceptive TG neurons (Type IV).

Negative_regulation (inhibited) of APs in neurons associated with nociception and trigeminal ganglion

1) Confidence 0.26 Published 2009 Journal Pain Section Abstract Doc Link 19376653 Disease Relevance 0.89 Pain Relevance 0.97

Because these APs were suppressed by the addition of cobalt or by the reduction of calcium, they were likely due to calcium currents (ICa).

Negative_regulation (suppressed) of APs associated with action potential

2) Confidence 0.25 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 7509858 Disease Relevance 0 Pain Relevance 0.50

In an opposite fashion, the result of GBP application to injured neurons was a decreased number of APs during depolarization and no change in RI.

Negative_regulation (number) of APs in neurons

3) Confidence 0.25 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15025616 Disease Relevance 0.13 Pain Relevance 0

RESULTS: Compared with normal neurons, injury decreased the refractory interval (RI) for repeat action potential (AP) generation increased the number of APs during sustained depolarization, and shortened the after hyperpolarization following an AP.

Negative_regulation (number) of APs in neurons

4) Confidence 0.25 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15025616 Disease Relevance 0.16 Pain Relevance 0

In an opposite fashion, the result of GBP application to injured neurons was a decreased number of APs during depolarization and no change in RI.

Negative_regulation (decreased) of APs in neurons

5) Confidence 0.25 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15025616 Disease Relevance 0.13 Pain Relevance 0

We tested this directly using MgGreen AM and found that the increase in internal calcium concentration shows no evidence of significant depression with increasing numbers of APs at 100?

Negative_regulation (numbers) of APs in internal associated with depression

6) Confidence 0.22 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.19 Pain Relevance 0.44

The number of APs generated during a long depolarizing current step fell from 5.3±0.5 to 3.5±0.3 (P<0.001, t-test).

Negative_regulation (number) of APs

7) Confidence 0.12 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.29

The average of numbers of APs for all 15 neurons after NaHS application were 6.8 ± 0.7, which is significantly higher than those before NaHS application (PRE 1.5 ± 0.2, n = 15, *p < 0.05).

Negative_regulation (numbers) of APs in neurons associated with action potential

8) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.48 Pain Relevance 0.57

Full APs were replaced by spikelet-like events of large amplitude (Figure 3A, arrow).

Negative_regulation (replaced) of APs

9) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.12 Pain Relevance 0.49

General Comments

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