INT48404

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 15.10
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
leukocyte 6
macrophage 4
brain 3
blood 3
plasma 2
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 125 100.00 Very High Very High Very High
cytokine 41 100.00 Very High Very High Very High
cINOD 25 100.00 Very High Very High Very High
IPN 24 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
aspirin 3 100.00 Very High Very High Very High
Pain score 2 99.08 Very High Very High Very High
Inflammatory marker 1 98.08 Very High Very High Very High
diclofenac 11 97.40 Very High Very High Very High
chemokine 15 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 136 100.00 Very High Very High Very High
Adhesions 60 100.00 Very High Very High Very High
Inflammatory Pain 24 100.00 Very High Very High Very High
Arthritis 9 100.00 Very High Very High Very High
Injury 27 99.90 Very High Very High Very High
Pain 5 99.08 Very High Very High Very High
Diabetes Mellitus 76 98.96 Very High Very High Very High
Nicotine Addiction 4 98.36 Very High Very High Very High
Hypertension 67 98.12 Very High Very High Very High
Rheumatoid Arthritis 104 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Indomethacin-induced damage in healthy and arthritic rats is largely dependent on ICAM-1 expression.
Regulation (dependent) of Gene_expression (expression) of ICAM-1
1) Confidence 0.62 Published 1995 Journal Gastroenterology Section Body Doc Link 7557083 Disease Relevance 0.12 Pain Relevance 0
Changes in ICAM-1 protein expression were noted at 48 h.
Regulation (Changes) of Gene_expression (expression) of ICAM-1
2) Confidence 0.62 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.84 Pain Relevance 1.06
The current study investigated effects of lambda-carrageenan-induced inflammatory pain (CIP) on BBB expression of ICAM-1.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of ICAM-1 associated with ipn
3) Confidence 0.62 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.77 Pain Relevance 0.95
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Regulation (altered) of Gene_expression (expression) of ICAM-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
4) Confidence 0.62 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.55 Pain Relevance 0.38
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Regulation (quantify) of Gene_expression (expression) of ICAM-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
5) Confidence 0.45 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.54 Pain Relevance 0.37
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Regulation (quantify) of Gene_expression (expression) of intercellular adhesion molecule-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
6) Confidence 0.45 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.54 Pain Relevance 0.37
Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa.
Regulation (Effect) of Gene_expression (expression) of ICAM-1 associated with aspirin, inflammation and cinod
7) Confidence 0.44 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7513960 Disease Relevance 0.60 Pain Relevance 0.43
OBJECTIVES: In the present study the authors investigated the role of neuroimmune activation using immunocytochemistry to detect expression of major histocompatibility complex Class II, cluster determinant 4, intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cellular adhesion molecule-1 (PECAM-1).
Regulation (detect) of Gene_expression (expression) of ICAM-1 in platelet
8) Confidence 0.39 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0.09 Pain Relevance 0
These results demonstrate that indomethacin-induced leukocyte adherence and mucosal injury are dependent on the expression of CD18 and ICAM-1.
Regulation (dependent) of Gene_expression (expression) of ICAM-1 in leukocyte associated with injury
9) Confidence 0.38 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7694504 Disease Relevance 0.79 Pain Relevance 0.26
No significant differences were noted between the 2 treatment groups in respect to ICAM-1 levels, VCAM-1 levels, WOMAC pain score, stiffness score, or physical function score at any time.
Regulation (respect) of Gene_expression (levels) of ICAM-1 associated with pain score
10) Confidence 0.34 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.76 Pain Relevance 0.42
In addition, Leukocyte's stagnation and infiltration also depend on the expression and function of ICAM, one kind of glycoprotein, which promotes cell-cell or cell extracellular matrix adhesion.
Regulation (depend) of Gene_expression (expression) of ICAM in extracellular matrix associated with adhesions
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 1.04 Pain Relevance 0.39
Rho/ROCK pathway promotes leukocyte adhesion to the microvasculature by affecting the expression and function of adhesion molecules, including ICAM-1 [28, 29] and integrins [30].
Regulation (affecting) of Gene_expression (expression) of ICAM-1 in leukocyte associated with adhesions
12) Confidence 0.28 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.03 Pain Relevance 0
Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain.
Regulation (Alterations) of in blood Gene_expression (expression) of ICAM-1 in brain associated with ipn and cytokine
13) Confidence 0.27 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16199477 Disease Relevance 0.76 Pain Relevance 1.31
Animal models have shown that radiation induced damage to the brain up regulates expression of TNF alpha, ICAM-1 and Il-1 [85].
Regulation (regulates) of Gene_expression (expression) of ICAM in brain
14) Confidence 0.26 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.63 Pain Relevance 0.65
The expression of iNOS and ICAM-1, second messengers of inflammation, was not affected, and inflammatory levels after 24 h with HbVs are similar to rat RBC transfusion.
Neg (not) Regulation (affected) of Gene_expression (expression) of ICAM-1 in HbVs associated with inflammation
15) Confidence 0.23 Published 2009 Journal ASAIO J. Section Abstract Doc Link 19625952 Disease Relevance 1.24 Pain Relevance 0.38
Involvement of reduced endothelial intercellular adhesion molecule-1 expression might explain the lower numbers of adherent and migrated leukocytes.
Regulation (Involvement) of Gene_expression (expression) of endothelial intercellular adhesion molecule-1 in leukocytes associated with adhesions
16) Confidence 0.20 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.59 Pain Relevance 0.55
B, which is one of the main regulator of ICAM-1 and iNOS gene expression.
Regulation (regulator) of Gene_expression (expression) of ICAM-1
17) Confidence 0.20 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.20 Pain Relevance 0
Peripheral NK1 receptor blockade did not alter endothelial expression of intercellular adhesion molecule-1 or local chemokine and cytokine production, but decreased polymorphonuclear cell and macrophage recruitment.
Neg (not) Regulation (alter) of Gene_expression (expression) of intercellular adhesion molecule-1 in macrophage
18) Confidence 0.16 Published 2007 Journal Anesthesiology Section Body Doc Link 18043070 Disease Relevance 0.06 Pain Relevance 0
Peripheral NK1 receptor blockade did not alter endothelial expression of intercellular adhesion molecule-1 or local chemokine and cytokine production, but decreased polymorphonuclear cell and macrophage recruitment.
Neg (not) Regulation (alter) of Gene_expression (production) of intercellular adhesion molecule-1 in macrophage
19) Confidence 0.16 Published 2007 Journal Anesthesiology Section Body Doc Link 18043070 Disease Relevance 0.06 Pain Relevance 0
Gene expression of ICAM-1, VCAM-1 and RANTES was unaltered whereas Osteopontin and MCP-1 were induced by hypertension.
Regulation (unaltered) of Gene_expression (expression) of ICAM-1 associated with hypertension
20) Confidence 0.15 Published 2005 Journal BMC Nephrol Section Abstract Doc Link PMC1175090 Disease Relevance 2.01 Pain Relevance 0.06

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