INT4842

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 4.59
Pain Relevance 13.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 3
outflow 1
cerebrospinal fluid 1
neurosecretory cells 1
brain 1
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 47 100.00 Very High Very High Very High
agonist 9 99.96 Very High Very High Very High
Inflammation 19 99.92 Very High Very High Very High
tolerance 5 99.84 Very High Very High Very High
Pain threshold 1 99.84 Very High Very High Very High
opiate 9 99.64 Very High Very High Very High
Spinal cord 35 99.42 Very High Very High Very High
Morphine 34 99.12 Very High Very High Very High
medulla 6 99.08 Very High Very High Very High
Central nervous system 4 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.92 Very High Very High Very High
Pain 27 99.84 Very High Very High Very High
Syndrome 13 98.48 Very High Very High Very High
Opiate Addiction 2 97.00 Very High Very High Very High
Tics 2 95.40 Very High Very High Very High
Inflammatory Pain 2 89.36 High High
Nociception 10 87.16 High High
Neuropathic Pain 2 84.08 Quite High
Hyperalgesia 1 75.00 Quite High
Anxiety Disorder 1 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible roles of the NPFF system in pain processing are summarized from the viewpoints of (1) biological activities of NPFF, (2) anatomical distribution of NPFF and its receptor(s) and (3) the regulation of NPFF and receptor(s) in animal models of pain.
Regulation (regulation) of NPFF associated with pain
1) Confidence 0.54 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.35 Pain Relevance 0.53
To further explore the functional role of PQRF-NH(2) peptides, we have studied their distribution and also the regulation of NPFF and NPVF systems in the spinal cord of rats with peripheral inflammation.
Regulation (regulation) of NPFF in spinal cord associated with inflammation and spinal cord
2) Confidence 0.54 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.54 Pain Relevance 0.72
Furthermore, there have been studies indicating that NPFF may participate in the regulation of pain threshold in the spinal cord.
Regulation (regulation) of NPFF in spinal cord associated with pain threshold and spinal cord
3) Confidence 0.45 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.10 Pain Relevance 0.61
The possible roles of the NPFF system in pain processing are summarized from the viewpoints of (1) biological activities of NPFF, (2) anatomical distribution of NPFF and its receptor(s) and (3) the regulation of NPFF and receptor(s) in animal models of pain.
Regulation (regulation) of NPFF associated with pain
4) Confidence 0.39 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.35 Pain Relevance 0.53
The present study examines the influence of NPFF on the expression of morphine- and ethanol-induced CPP in the biased procedure in rats.
Spec (examines) Regulation (influence) of NPFF associated with morphine
5) Confidence 0.39 Published 2007 Journal Peptides Section Abstract Doc Link 17884254 Disease Relevance 0.07 Pain Relevance 0.80
This hypothesis was directly assessed by investigating the effects of a NPFF analogue, 1DMe ([D-Tyr1,(NMe)Phe3]NPFF), on the spinal outflow of met-enkephalin-like material (MELM) in halothane-anaesthetised rats.
Spec (investigating) Regulation (effects) of NPFF in outflow associated with halothane and enkephalin
6) Confidence 0.39 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471085 Disease Relevance 0 Pain Relevance 0.63
Neuropeptide FF (NPFF) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (PVN).
Regulation (control) of NPFF in neurosecretory cells associated with neuropeptide
7) Confidence 0.38 Published 2006 Journal Peptides Section Title Doc Link 16517015 Disease Relevance 0 Pain Relevance 0.29
In contrast, the presence of a glycine residue in position 5 did not influence the affinity toward NPFF receptors.
Neg (not) Regulation (influence) of NPFF
8) Confidence 0.32 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 7932576 Disease Relevance 0 Pain Relevance 0.67
In the present study, we have investigated the effect of NPFF agonists on the coupling of the Mu-opioid (MOP) receptor to G-proteins in a model of SH-SY5Y cells transfected with NPFF(2) receptor, in which the neuronal anti-opioid activity of NPFF was previously reproduced.
Spec (investigated) Regulation (effect) of NPFF in neuronal associated with agonist and opioid
9) Confidence 0.27 Published 2010 Journal Neurochem. Int. Section Abstract Doc Link 20211672 Disease Relevance 0 Pain Relevance 0.89
We confirm the validity of the in situ hybridization by showing that its distribution in the brain and spinal cord matches the distribution of NPFF and NPSF immunoreactivity.
Regulation (immunoreactivity) of NPFF in spinal cord associated with spinal cord
10) Confidence 0.26 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.39 Pain Relevance 0.87
Regulation and localization of spinal NPFF systems, taken together with the analgesic bioactivity of intrathecally administered NPFF, strongly suggest involvement of spinal NPFF system in pain processing.
Regulation (Regulation) of NPFF in spinal associated with pain and analgesic
11) Confidence 0.24 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.56 Pain Relevance 0.65
In the present study, we examined the chronic effects of NPFF and its synthetic analogs: the putative agonist, PFRFamide, and the putative antagonists, dansyl-PQRamide and PFR(Tic)amide on naloxone-precipitated morphine withdrawal syndromes in rats.
Spec (examined) Regulation (effects) of NPFF associated with tics, syndrome, antagonist, narcan, agonist, withdrawal and morphine
12) Confidence 0.23 Published 1999 Journal Peptides Section Abstract Doc Link 10573293 Disease Relevance 0.38 Pain Relevance 1.11
These results clearly indicate that modulation of the NPFF system in the mammalian central nervous system has significant effects on opiate dependence.
Regulation (modulation) of NPFF in central nervous system associated with addiction, opiate and central nervous system
13) Confidence 0.23 Published 1999 Journal Peptides Section Abstract Doc Link 10573293 Disease Relevance 0.71 Pain Relevance 1.48
The findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation and this possibility is further supported by the distribution of NPFF and its receptor and the regulation of the NPFF system in vivo.
Regulation (regulation) of NPFF associated with pain, analgesic and morphine
14) Confidence 0.23 Published 2008 Journal Neuropeptides Section Abstract Doc Link 17854890 Disease Relevance 0.42 Pain Relevance 1.06
These findings and the observed increase in NPFF-immunoreactivity in the cerebrospinal fluid during development of opiate tolerance render NPFF an interesting and challenging target of investigation.
Regulation (target) of NPFF in cerebrospinal fluid associated with tolerance and opiate
15) Confidence 0.23 Published 1996 Journal Prog. Neurobiol. Section Abstract Doc Link 8804117 Disease Relevance 0.18 Pain Relevance 0.76
A structure-activity study was carried out to determine the importance of the C-terminal amino acids of the octapeptide Neuropeptide FF (NPFF) in binding and agonistic activity.
Spec (determine) Regulation (importance) of NPFF associated with neuropeptide
16) Confidence 0.19 Published 2001 Journal Peptides Section Abstract Doc Link 11514031 Disease Relevance 0 Pain Relevance 0.20
The distribution pattern of hNPFF2 in the AGM spinal cord and the lower level of the brainstem are consistent with a hypothesized potential role for NPFF peptides in modulation of sensory input, opioid analgesia and morphine tolerance through spinal and supraspinal mechanisms.
Spec (hypothesized) Regulation (role) of NPFF in brainstem associated with medulla, tolerance, opioid, morphine, analgesia and spinal cord
17) Confidence 0.17 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12842272 Disease Relevance 0.15 Pain Relevance 0.96
We confirm the validity of the in situ hybridization by showing that its distribution in the brain and spinal cord matches the distribution of NPFF and NPSF immunoreactivity.
Regulation (immunoreactivity) of NPFF in brain associated with spinal cord
18) Confidence 0.09 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.39 Pain Relevance 0.87

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