INT48536

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 46
Total Number 56
Disease Relevance 14.31
Pain Relevance 23.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm8) signal transducer activity (Grm8)
Anatomy Link Frequency
neuronal 3
astrocytes 2
macrophages 1
Shank 1
spike 1
Grm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 498 100.00 Very High Very High Very High
Glutamate receptor 136 100.00 Very High Very High Very High
Inflammation 134 100.00 Very High Very High Very High
Glutamate 1090 99.92 Very High Very High Very High
GABAergic 107 99.84 Very High Very High Very High
long-term potentiation 64 99.80 Very High Very High Very High
Action potential 157 99.68 Very High Very High Very High
Substantia nigra 48 99.66 Very High Very High Very High
antagonist 238 99.56 Very High Very High Very High
amygdala 71 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 459 99.28 Very High Very High Very High
Urological Neuroanatomy 42 99.28 Very High Very High Very High
Disease 504 99.16 Very High Very High Very High
Neuropathic Pain 20 98.94 Very High Very High Very High
Hyperalgesia 24 98.78 Very High Very High Very High
INFLAMMATION 152 98.60 Very High Very High Very High
Pain 128 98.22 Very High Very High Very High
Arthritis 38 98.12 Very High Very High Very High
Hypersensitivity 7 97.80 Very High Very High Very High
Nociception 39 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of glutamate at low concentrations (<3 microM) raised [Ca2+]c mainly by activating metabotropic glutamate receptors (mGluR), whereas at high concentrations (>10 microM) it raised [Ca2+]c mainly by activating AMPA/kainate receptors.
Positive_regulation (activating) of mGluR associated with glutamate and glutamate receptor
1) Confidence 0.61 Published 2003 Journal J. Cell. Sci. Section Abstract Doc Link 12746490 Disease Relevance 0 Pain Relevance 1.22
In the present study, we investigated the potential role of peripheral group I metabotropic glutamate receptors (mGluRs 1/5) in the development of muscular hypersensitivity to mechanical stimulation, and attempted to elucidate intracellular signaling mechanisms associated with the mGluR activation in male Sprague-Dawley rats.
Positive_regulation (activation) of mGluR associated with glutamate receptor and hypersensitivity
2) Confidence 0.60 Published 2007 Journal Neuroscience Section Abstract Doc Link 17306466 Disease Relevance 0.41 Pain Relevance 0.28
Responses to metabotropic glutamate receptor (mGluR) activation were investigated in acutely dissociated rat neostriatal (caudate putamen, CP) large cholinergic neurons, with the use of a nystatin-perforated patch-clamp technique. 2.
Positive_regulation (activation) of mGluR in caudate putamen associated with glutamate receptor
3) Confidence 0.49 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8890274 Disease Relevance 0 Pain Relevance 0.23
The present results suggest that the dendritic release of DA in the SN is regulated by mGluR activation.
Positive_regulation (activation) of mGluR associated with substantia nigra
4) Confidence 0.46 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11960611 Disease Relevance 0 Pain Relevance 0.51
Such nigral mGluR activation may produce opposite effects upon basal and NMDA-evoked release of DA in the SN.
Positive_regulation (activation) of mGluR associated with substantia nigra
5) Confidence 0.46 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11960611 Disease Relevance 0 Pain Relevance 0.51
Taken together, these results point to a use dependent change in CA3 neuronal network function produced by group I mGluR activation.
Positive_regulation (activation) of mGluR in neuronal
6) Confidence 0.45 Published 2008 Journal Epilepsy Res. Section Abstract Doc Link 18495430 Disease Relevance 0.06 Pain Relevance 0.28
mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia.
Positive_regulation (activation) of mGluR associated with hyperalgesia and inflammation
7) Confidence 0.45 Published 1998 Journal Neuroreport Section Title Doc Link 9601694 Disease Relevance 0.62 Pain Relevance 0.68
The effect of metabotropic glutamate receptor (mGluR) activation on GABAergic synaptic transmission in rat periaqueductal grey (PAG) neurons was examined using whole-cell patch-clamp recordings in brain slices.
Spec (examined) Positive_regulation (activation) of mGluR in brain associated with periaqueductal grey, gabaergic and glutamate receptor
8) Confidence 0.44 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.34 Pain Relevance 0.43
These results reveal a dual modulation of mGLuR activation on inhibitory transmission in midbrain ventral tegmental area: enhancing putative GABAergic neuronal excitability and thus potentiating tonic inhibitory synaptic transmission while reducing evoked synaptic transmission at inhibitory terminals.
Positive_regulation (activation) of mGLuR in midbrain associated with ventral tegmentum, neuronal excitability, gabaergic and midbrain
9) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12770559 Disease Relevance 0 Pain Relevance 0.87
Thus, the effects of GABA(B) receptor activation would suppress auditory signal transfer, whereas mGluR activation enhances excitability, possibly accounting for the alerting effects of certain auditory stimuli.
Spec (possibly) Positive_regulation (activation) of mGluR associated with gaba
10) Confidence 0.42 Published 2000 Journal Acta Otolaryngol. Section Abstract Doc Link 11603784 Disease Relevance 0 Pain Relevance 0.30
Activation of mGluR elicited a Ca2+ release from intracellular Ca2+ stores and continuous Ca2+ influx out of the cell.
Positive_regulation (Activation) of mGluR
11) Confidence 0.41 Published 2003 Journal J. Cell. Sci. Section Abstract Doc Link 12746490 Disease Relevance 0 Pain Relevance 1.21
These results indicate that GABAergic synaptic transmission within the PAG is reduced by groups I, II and III mGluR activation via a presynaptic mechanism and is increased by group I mGluR activation via an action potential dependent mechanism.
Positive_regulation (activation) of mGluR associated with action potential, periaqueductal grey and gabaergic
12) Confidence 0.41 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.36 Pain Relevance 0.64
These results indicate that GABAergic synaptic transmission within the PAG is reduced by groups I, II and III mGluR activation via a presynaptic mechanism and is increased by group I mGluR activation via an action potential dependent mechanism.
Positive_regulation (activation) of mGluR associated with action potential, periaqueductal grey and gabaergic
13) Confidence 0.41 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15081789 Disease Relevance 0.37 Pain Relevance 0.64
Group I mGluR activation can initiate a number of intracellular pathways that increase neuronal excitability.
Positive_regulation (activation) of mGluR in neuronal associated with neuronal excitability
14) Confidence 0.39 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11476590 Disease Relevance 0.54 Pain Relevance 0.43
These data suggest that ACPT-1 modifies eEPSCs by a direct action at the presynaptic terminal suggesting that group III mGluR activation depresses eEPSCs by reducing Ca2+-entry, a possibility we investigated next.


Positive_regulation (activation) of mGluR
15) Confidence 0.39 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.29 Pain Relevance 0.18
If we assume that the pool of vesicles available for evoked release is the same as that for mEPSCs, then an increase in mEPSCs by mGluR activation could deplete the releasable pool available for the eEPSC.
Positive_regulation (activation) of mGluR in vesicles
16) Confidence 0.39 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.06 Pain Relevance 0.14
The data point to an activation of group II mGluR by noxious inputs in the Rt of MA rats, suggesting their participation in inhibiting local gamma-aminobutyric acid (GABA)ergic inhibitory neurones.
Positive_regulation (activation) of mGluR associated with gaba
17) Confidence 0.38 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11099825 Disease Relevance 0.25 Pain Relevance 0.37
Specific blockade of R-type channels with SNx did not have any overall effect on the ability of group III mGluR activation to depress eEPSCs.
Positive_regulation (activation) of mGluR
18) Confidence 0.34 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.09 Pain Relevance 0.08
GABA release in layer V is also decreased by group III mGluR activation (Woodhall et al., 2001a).
Positive_regulation (activation) of mGluR associated with gaba
19) Confidence 0.34 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.11 Pain Relevance 0.31
The agonist-produced impairment was rescued by coinfusion of forskolin, suggesting that mGluR II may act in synchrony with other receptors including mGluR I and DA1-like receptors to produce an optimal level of PKA activation.
Positive_regulation (activation) of mGluR associated with agonist
20) Confidence 0.33 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501036 Disease Relevance 0.16 Pain Relevance 0.83

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