INT48555

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 11.38
Pain Relevance 6.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
lymphocytes 4
tendon 3
proximal 2
neurons 1
connective tissue 1
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 79 99.02 Very High Very High Very High
Pain 13 98.76 Very High Very High Very High
narcan 6 96.76 Very High Very High Very High
Cholecystokinin 7 96.44 Very High Very High Very High
antagonist 13 96.36 Very High Very High Very High
agonist 41 96.28 Very High Very High Very High
melanocortin 1 receptor 10 94.44 High High
Morphine 22 91.80 High High
Enkephalin 3 91.72 High High
Opioid 3 86.28 High High
Disease Link Frequency Relevance Heat
Mixed Connective Tissue Disorder 5 99.44 Very High Very High Very High
Tendinopathy 20 99.08 Very High Very High Very High
Pancreatic Cancer 5 99.00 Very High Very High Very High
Rupture 20 98.32 Very High Very High Very High
Infection 36 97.16 Very High Very High Very High
Tendon Injuries 5 97.12 Very High Very High Very High
Repression 10 95.20 Very High Very High Very High
Adhesions 11 94.52 High High
Asthma 69 93.04 High High
Syndrome 18 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we conclude that the cooperative interaction of Sp1 and YY1 transcription factors is the critical event triggering the initiation of transcription of the MOR gene in lymphocytes, and this finding will be helpful to understand the pharmacological effect of morphine on lymphocytes.
Sp1 Binding (interaction) of in lymphocytes associated with mu opioid receptor and morphine
1) Confidence 0.46 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.44
The electrophoretic mobility shift assay showed that two transcription factors, Sp1 and YY1, were able to bind the promoter region.
Sp1 Binding (bind) of
2) Confidence 0.46 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.36
Such enhanced binding of Sp1/Sp3 to the promoter may lead to a functional change in hMOR gene transcription.
Sp1 Binding (binding) of
3) Confidence 0.41 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.36
Sp1 and Sp3 bound to this 60 bp region, which was confirmed by electromobility shift assays using a Sp1 consensus oligo as competitor and specific antibodies against Sp1 and Sp3.
Sp1 Binding (bound) of
4) Confidence 0.41 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.58
We demonstrate that substitution of the C-36 residue causes a slight reduction of Sp1 and Sp3 binding, but this has no effect on transcription in vivo.
Sp1 Binding (binding) of
5) Confidence 0.39 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.76 Pain Relevance 0.39
A functional Sp1-binding site polymorphism (SNP rs1800012; IVS1+1023G>T) within this gene has been shown to be associated with several connective tissue disorders.
Sp1 Binding (associated) of in connective tissue associated with mixed connective tissue disorder
6) Confidence 0.36 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.67 Pain Relevance 0.10
In conclusion, this study has shown that there is no association between the Sp1-binding site polymorphism within the first intron of COL1A1 and Achilles tendinopathy or Achilles tendon rupture within the population studied.
Sp1 Neg (no) Binding (association) of in tendon associated with rupture and tendinopathy
7) Confidence 0.36 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.81 Pain Relevance 0.07
The aim of this study was to determine whether the Sp1-binding site polymorphism within the COL1A1 gene is associated with chronic Achilles tendinopathies and/or spontaneous Achilles tendon ruptures.
Sp1 Binding (associated) of in tendon associated with rupture and tendinopathy
8) Confidence 0.36 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.71 Pain Relevance 0.09
was shown to be closely dependent on the transcription factor early growth response factor-1 (Egr-1) [57], although activator protein-1 and specificity protein-1 binding sites were also found [62].
specificity protein-1 Binding (binding) of
9) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.03
Furthermore, coimmunoprecipitation and transfection assays confirmed that the functional interaction of Sp1 and YY1 transcription factors was a crucial step in the initiation of expression of the MOR in lymphocytes.
Sp1 Binding (interaction) of in lymphocytes associated with mu opioid receptor
10) Confidence 0.36 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.48
Achilles tendinopathy (n=85), Achilles rupture (n=41) and asymptomatic control (n=125) participants were genotyped for the COL1A1 Sp1-binding site polymorphism.
Sp1 Binding (binding) of associated with rupture and tendinopathy
11) Confidence 0.35 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.68 Pain Relevance 0.08
Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls.
Sp1 Binding (binding) of in tendon associated with tendon injuries
12) Confidence 0.35 Published 2009 Journal J Sci Med Sport Section Title Doc Link 18353721 Disease Relevance 0.60 Pain Relevance 0.08
Transfection with Sp1-expressing vector (PN3-Sp1) was also able to enhance the activity of the promoter in SIVmac239-infected cells.
Sp1 Binding (Transfection) of
13) Confidence 0.34 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.74 Pain Relevance 0.39
Transfection with Sp1-expressing vector (PN3-Sp1) was also able to enhance the activity of the promoter in SIVmac239-infected cells.
Sp1-expressing Binding (Transfection) of
14) Confidence 0.34 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.73 Pain Relevance 0.39
Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.
specificity protein 1 Binding (interaction) of in lymphocytes associated with mu opioid receptor
15) Confidence 0.34 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.59 Pain Relevance 0.35
Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.
Sp1 Binding (interaction) of in lymphocytes associated with mu opioid receptor
16) Confidence 0.34 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35
The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.
Sp1 Spec (determined) Binding (binding) of
17) Confidence 0.33 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.75 Pain Relevance 0.35
Taken together, the present studies demonstrated, for the first time, that the binding of Sp1/Sp3 to the hMOR proximal promoter could be modulated by chronic DAMGO treatment.
Sp1 Binding (binding) of in proximal
18) Confidence 0.30 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.41
These characteristics include GC-rich sequence, lack of a TATA box, and binding of SP-1.
SP-1 Binding (binding) of
19) Confidence 0.23 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10462496 Disease Relevance 0.09 Pain Relevance 0.37
Gel shift assays targeting the three GC boxes confirmed binding of SP-1.
SP-1 Binding (binding) of
20) Confidence 0.23 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10462496 Disease Relevance 0.09 Pain Relevance 0.39

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