INT48568

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Context Info
Confidence 0.06
First Reported 1994
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
caudate-putamen 1
Kcnk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 6 99.96 Very High Very High Very High
opioid receptor 18 99.90 Very High Very High Very High
substance P 3 96.96 Very High Very High Very High
Morphine 7 96.76 Very High Very High Very High
Dopamine 9 90.84 High High
Neuropeptide 3 89.20 High High
cocaine 4 82.16 Quite High
midbrain 1 81.44 Quite High
Substantia nigra 1 79.52 Quite High
Opioid 2 78.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neurons, suggesting a possible mechanism whereby D1R modulation may alter DOR function.
Regulation (modulation) of D1R in neurons associated with opioid receptor
1) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.67
Dual immunoperoxidase/gold-silver detection combined with electron microscopy was used to identify DOR and D1R immunoreactivities in the same section of tissue.
Regulation (immunoreactivities) of D1R associated with opioid receptor
2) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.76
As reported previously by others, there was no alteration in D1R mRNA and a 25% decrease in D2R mRNA in the caudate-putamen, 2 h after the final morphine injection.
Neg (no) Regulation (alteration) of D1R in caudate-putamen associated with morphine
3) Confidence 0.01 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.84
The D1 dopamine receptor (D1R) mRNA level was not significantly modified after either treatment.
Neg (not) Regulation (modified) of D1R associated with dopamine receptor
4) Confidence 0.00 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.37

General Comments

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