INT48786

From wiki-pain
Revision as of 14:58, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.89
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
AcSh 1
neurons 1
kidney 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 17 100.00 Very High Very High Very High
nMDA receptor 13 100.00 Very High Very High Very High
Dopamine 1 99.82 Very High Very High Very High
excitatory amino acid 2 99.80 Very High Very High Very High
tetrodotoxin 4 99.66 Very High Very High Very High
central sensitization 3 97.68 Very High Very High Very High
Dynorphin 1 94.72 High High
Enkephalin 3 94.12 High High
antagonist 8 93.20 High High
spinothalamic tract 3 91.08 High High
Disease Link Frequency Relevance Heat
Nociception 7 90.24 High High
Parkinson's Disease 5 90.16 High High
Neuropathic Pain 6 88.28 High High
Hyperalgesia 18 87.72 High High
Pain 8 81.04 Quite High
Dyskinesias 2 80.64 Quite High
Disease 5 72.00 Quite High
Pruritus 1 65.48 Quite High
Li-fraumeni Syndrome 24 65.12 Quite High
Depression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This same peptide was basally phosphorylated in recombinant GluR1 receptors transiently expressed in human embryonal kidney 293 cells.
Phosphorylation (phosphorylated) of GluR1 in kidney
1) Confidence 0.80 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.24
In hemiparkinsonian rats, KW6002 reversed the intermittent L-dopa treatment-induced, protein kinase A-mediated hyperphosphorylation of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid receptor GluR1 S845 residues and the concomitant shortening in motor response duration.
Phosphorylation (hyperphosphorylation) of GluR1
2) Confidence 0.80 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.66 Pain Relevance 0.32
The mechanism of the increase in responses to excitatory amino acids includes phosphorylation of NR1 subunits of NMDA receptors and GluR1 subunits of AMPA receptors.
Phosphorylation (phosphorylation) of GluR1 associated with nmda receptor and excitatory amino acid
3) Confidence 0.79 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19294370 Disease Relevance 0.88 Pain Relevance 1.54
Biochemical analysis in AcSh explants showed that MCH signaling blocks dopamine-induced phosphorylation of the AMPA glutamate receptor subunit GluR1 at Ser845.
Phosphorylation (phosphorylation) of GluR1 in AcSh associated with dopamine and glutamate receptor
4) Confidence 0.61 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15772353 Disease Relevance 0 Pain Relevance 0.59
In cultures in which this synaptic activity was suppressed by tetrodotoxin and MK-801, the GluR1 protein was phosphorylated on serine residues within a single tryptic phosphopeptide, as determined by phosphoamino acid analysis and phosphopeptide mapping.
Phosphorylation (phosphorylated) of GluR1 protein associated with tetrodotoxin
5) Confidence 0.33 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.26
In this study, we have investigated the phosphorylation of the AMPA-preferring glutamate receptor subunit GluR1 in cortical neurons in primary culture.
Spec (investigated) Phosphorylation (phosphorylation) of AMPA in neurons associated with glutamate receptor
6) Confidence 0.22 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.25
Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors.
Phosphorylation (phosphorylation) of AMPA associated with glutamate receptor
7) Confidence 0.22 Published 1994 Journal J. Neurosci. Section Title Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.25
CaMKII is activated by an increased [Ca2+]i and phosphorylates AMPA receptors, thereby increasing their channel conductance.
Phosphorylation (phosphorylates) of AMPA
8) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.35 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox