INT4879

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 12.48
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
lymph node 4
liver 2
leukocytes 2
melanocyte 2
carotid body 2
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 2 98.96 Very High Very High Very High
substance P 26 98.36 Very High Very High Very High
Neuropeptide 15 98.12 Very High Very High Very High
Morphine 4 97.84 Very High Very High Very High
Enkephalin 11 97.40 Very High Very High Very High
Chronic pancreatitis 3 91.20 High High
Inflammation 15 89.44 High High
agonist 1 85.52 High High
Calcitonin gene-related peptide 3 83.68 Quite High
calcitonin gene related peptide 1 83.44 Quite High
Disease Link Frequency Relevance Heat
Melanoma 5 100.00 Very High Very High Very High
Cancer 554 99.98 Very High Very High Very High
Prostate Cancer 131 99.98 Very High Very High Very High
Renal Cancer 39 99.52 Very High Very High Very High
Disease 91 99.08 Very High Very High Very High
Necrosis 4 98.70 Very High Very High Very High
Metastasis 133 98.48 Very High Very High Very High
Hypoxia 7 98.36 Very High Very High Very High
Recurrence 54 97.24 Very High Very High Very High
Injury 1 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD10 expression is greater in more advanced primary melanomas and is upregulated in metastatic lesions compared with the corresponding primary tumors [5,6].
Positive_regulation (upregulated) of Gene_expression (expression) of CD10 associated with cancer and melanoma
1) Confidence 0.69 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.14 Pain Relevance 0.11
We postulate that prostate tumors expressing high levels of CD10 correlate with a poor disease outcome.
Positive_regulation (levels) of Gene_expression (expressing) of CD10 associated with prostate cancer and disease
2) Confidence 0.69 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.75 Pain Relevance 0
Comparative array analysis among Gleason pattern 3, pattern 4 and pattern 5 tumors microdissected by laser-capture showed increased CD10 expression in the higher patterns [17]; a trend also reported by the study of Osman et al. [13].
Positive_regulation (increased) of Gene_expression (expression) of CD10 associated with cancer
3) Confidence 0.69 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.51 Pain Relevance 0
Treatment of PATU-8988T cells with the histone deacetylase inhibitors sodium butyrate and valproic acid induced an increase of NEP/CD10 expression.
Positive_regulation (induced) of Gene_expression (expression) of CD10
4) Confidence 0.67 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17294442 Disease Relevance 1.12 Pain Relevance 0.09
We conclude that neutral endopeptidase can be increased by cell growth or density and by glucocorticoids and that the effects of glucocorticoids are mediated by increased NEP gene expression.
Positive_regulation (increased) of Gene_expression (expression) of NEP gene
5) Confidence 0.63 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.11
Specifically, in tumor necrosis factor (TNF)-treated immunocytes, we demonstrate the effects of increased NEP expression on altering the stimulatory activities of the neuropeptides met-enkephalin, melanocyte-stimulating hormone and substance P.
Positive_regulation (increased) of Gene_expression (expression) of NEP in melanocyte associated with necrosis, cancer, neuropeptide, enkephalin and substance p
6) Confidence 0.60 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281168 Disease Relevance 0.35 Pain Relevance 0.37
Of 68 CRC patients, 19 (28%) showed CD10 expression, which was dependent on the extent of liver metastasis.
Positive_regulation (dependent) of Gene_expression (expression) of CD10 in liver
7) Confidence 0.58 Published 2010 Journal Gut Section Body Doc Link 19828468 Disease Relevance 0 Pain Relevance 0
Quantitative DPP IV and NEP expression profile in renal tumors
Positive_regulation (Quantitative) of Gene_expression (expression) of NEP associated with renal cancer
8) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.42 Pain Relevance 0
Treatment of PATU-8988T cells with the histone deacetylase inhibitors sodium butyrate and valproic acid induced an increase of NEP/CD10 expression.
Positive_regulation (increase) of Gene_expression (expression) of NEP
9) Confidence 0.49 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17294442 Disease Relevance 1.11 Pain Relevance 0.09
We found that patients with primary tumors expressing high levels of CD10 were more likely to harbor lymph node metastasis and experience PSA recurrence after RP.
Positive_regulation (levels) of Gene_expression (expressing) of CD10 in lymph node associated with cancer, recurrence and metastasis
10) Confidence 0.46 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.47 Pain Relevance 0
We hypothesize that prostate tumors expressing high levels of CD10 have a more aggressive biology with an early propensity towards lymph node metastasis.


Positive_regulation (levels) of Gene_expression (expressing) of CD10 in lymph node associated with prostate cancer and metastasis
11) Confidence 0.46 Published 2007 Journal BMC Urol Section Abstract Doc Link PMC1829163 Disease Relevance 0.85 Pain Relevance 0
Treatment of PATU-8988T cells with the histone deacetylase inhibitors sodium butyrate and valproic acid induced an increase of NEP/CD10 expression.
Positive_regulation (increase) of Gene_expression (expression) of CD10
12) Confidence 0.45 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17294442 Disease Relevance 1.11 Pain Relevance 0.09
The distribution of NEP detected immunocytochemically using anti-NEP monoclonal antibodies was also found to be parallel with the distribution of NEP activity among peripheral blood leukocytes.
Positive_regulation (using) of Gene_expression (detected) of NEP in leukocytes
13) Confidence 0.44 Published 1991 Journal J. Leukoc. Biol. Section Abstract Doc Link 1991995 Disease Relevance 0.08 Pain Relevance 0.11
The increased expression of NEP downregulates the stimulatory effect of substance P and TNF.
Positive_regulation (increased) of Gene_expression (expression) of NEP associated with substance p
14) Confidence 0.40 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7519178 Disease Relevance 0.31 Pain Relevance 0.69
Intranasal steroid treatment increases NEP, and potentially DPP IV, expression.
Positive_regulation (increases) of Gene_expression (expression) of NEP
15) Confidence 0.12 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.55 Pain Relevance 0.48
One hundred forty-nine of 163 DLBCLs could then be classified into GCB group (pattern A), activated GCB group (pattern B), and activated non-GCB group (pattern C) according to the expression of CD10, BCL6, MUM1, and CD138.
Positive_regulation (according) of Gene_expression (expression) of CD10
16) Confidence 0.09 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.47 Pain Relevance 0
Carotid body expresses neutral endopeptidase (NEP)-like enzyme activity and phosphoramidon, an inhibitor of NEP augments sensory response of the carotid body to hypoxia (Kumar et al., 1990).
Positive_regulation (augments) of Gene_expression (expresses) of NEP in carotid body associated with hypoxia
17) Confidence 0.01 Published 2000 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10849712 Disease Relevance 0.24 Pain Relevance 0.32

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