INT48850

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 1.93
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PKN1) signal transduction (PKN1) histone binding (PKN1)
plasma membrane (PKN1) nucleus (PKN1) intracellular (PKN1)
Anatomy Link Frequency
Node 3
pore 1
lower limb 1
foot 1
stem cells 1
PKN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 19 100.00 Very High Very High Very High
Somatosensory cortex 13 99.90 Very High Very High Very High
primary somatosensory cortex 3 98.80 Very High Very High Very High
ischemia 14 90.96 High High
Spinal cord 35 90.48 High High
anesthesia 9 52.96 Quite High
Inflammation 19 50.00 Quite Low
nociceptor 3 25.00 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Neurological Disease 14 98.44 Very High Very High Very High
Glioma 35 98.40 Very High Very High Very High
Targeted Disruption 21 97.68 Very High Very High Very High
Nicotine Addiction 5 94.80 High High
Cancer 43 93.20 High High
Cv Unclassified Under Development 7 90.96 High High
Injury 14 89.44 High High
Pre-eclampsia 8 80.44 Quite High
Frailty 7 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SII) to the N1 generation for stimulation of upper and lower limb.
Gene_expression (generation) of N1 in upper associated with somatosensory cortex
1) Confidence 0.52 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8897487 Disease Relevance 0 Pain Relevance 0.31
The role of the secondary somatosensory cortex (SII) in generation of the N1 is established for the upper but not for the lower limb.
Gene_expression (generation) of N1 in secondary somatosensory cortex associated with somatosensory cortex
2) Confidence 0.52 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8897487 Disease Relevance 0 Pain Relevance 0.30
It is therefore concluded that N1 of the foot pain SEPs is generated mainly from the foot area of SI.
Gene_expression (generated) of N1 in foot associated with pain and primary somatosensory cortex
3) Confidence 0.35 Published 1995 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 7530185 Disease Relevance 0.55 Pain Relevance 0.78
SII) to the N1 generation for stimulation of upper and lower limb.
Gene_expression (generation) of N1 in lower limb associated with somatosensory cortex
4) Confidence 0.18 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8897487 Disease Relevance 0 Pain Relevance 0.31
For integrating pathways P1 and P2, as in Figure 1A, PINT uses the following criteria to determine if nodes N1 and N2 can be linkers:
Gene_expression (nodes) of N1 in nodes
5) Confidence 0.06 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
Node N1 is in the same compartment as node N2.Node N1 consists of exactly the same set of entities as node N2 does.Entities considered to be identical are annotated with exactly the same properties (e.g. symbols, accession numbers and modifications).
Gene_expression (is) of N1 in Node
6) Confidence 0.06 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
Node N1 is in the same compartment as node N2.Node N1 consists of exactly the same set of entities as node N2 does.Entities considered to be identical are annotated with exactly the same properties (e.g. symbols, accession numbers and modifications).
Gene_expression (consists) of N1 in Node
7) Confidence 0.06 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
In both groups, maternal S100B levels were significantly lower than fetal and neonatal ones (N1 and N4), while N1 S100B levels were significantly higher than respective UC ones.
Gene_expression (levels) of N1
8) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.33 Pain Relevance 0
For example element n2 has afferents from itself and n1, and fires if it receives input pattern (n1, n2)?
Gene_expression (itself) of n1
9) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Cells were transfected with pEGFP-N1 or pEGFP-BDNF by liposome-based reagent, Gene Porter2 (Gene Therapy System, San Diego, CA, USA), established electroporators; Nucleofector® (Amaxa, Cologne, Germany), ECM 830 (BTX Harvard Apparatus, Holliston, MA, USA), MicroPulser™ (Bio-Rad, Huston, TX, USA) and a novel electroporator (MicroPorator™, Digital Bio, Seoul, Korea).
Gene_expression (transfected) of pEGFP-N1
10) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.07 Pain Relevance 0
Additionally, microporation-mediated transfection of pEGFP-N1 into hUCB-MSCs and EGFP overexpression did not affect the multiple potential of stem cells.
Gene_expression (transfection) of pEGFP-N1 in stem cells
11) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.49 Pain Relevance 0.17
Both non-transfected hUCB-MSCs and hUCB-MSCs transfected with pEGFP-N1 grew in a similar fashion in a time-dependent manner (Figure 5A).
Gene_expression (transfected) of pEGFP-N1
12) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0
m pore filters. 1 × 106 of cells were incubated in 5 ml serum free MEM for U-87MG or DMEM for astrocytes for 48 hr, and the resulting conditioned media were used as chemoattractants. hUCB-MSCs or hUCB-MSCs transfected with pEGFP-N1 (2 × 104) were suspended in 100 ?
Gene_expression (transfected) of pEGFP-N1 in pore
13) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0.05
An EGFP expression vector, pEGFP-N1, was purchased from Clontech BD Bioscience (Palo Alto, CA, USA).
Gene_expression (expression) of pEGFP-N1
14) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.17 Pain Relevance 0
To test this in hUCB-MSCs transfected with pEGFP-N1 by microporation, in vitro migration assays using Transwell plates were conducted.
Gene_expression (transfected) of pEGFP-N1
15) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.26 Pain Relevance 0
To evaluate the influence of microporation on multilineage differentiation of hUCB-MSCs, hUCB-MSCs and hUCB-MSCs transfected with pEGFP-N1 by microporation were induced into osteogenic and adipogenic differentiation.
Gene_expression (transfected) of pEGFP-N1
16) Confidence 0.01 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.05 Pain Relevance 0

General Comments

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