INT48854

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CALCB) extracellular region (CALCB)
Anatomy Link Frequency
nerves 1
primary sensory neurons 1
CALCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 100.00 Very High Very High Very High
calcitonin gene related peptide 3 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Neurotransmitter 3 99.48 Very High Very High Very High
Inflammation 7 97.70 Very High Very High Very High
Chronic pancreatitis 6 95.52 Very High Very High Very High
antagonist 5 93.76 High High
Nerve growth factor 8 91.32 High High
qutenza 18 90.96 High High
Disease Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Nociception 5 99.90 Very High Very High Very High
Hypersensitivity 2 99.90 Very High Very High Very High
INFLAMMATION 6 97.70 Very High Very High Very High
Pancreatitis 6 95.52 Very High Very High Very High
Fibrosis 1 91.96 High High
Cholestasis 1 82.96 Quite High
Pathologic Constriction 1 80.16 Quite High
Pressure And Volume Under Development 1 68.08 Quite High
Erythema 1 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, immunohistological studies have shown that the amount of neurotransmitters, such as substance P and calcitonin gene related peptide, is increased in afferent pancreatic nerves and a close interrelationship between pain and immune cell infiltration of the nerves has been reported in CP.
Positive_regulation (increased) of calcitonin gene in nerves associated with pain, calcitonin gene related peptide, neurotransmitter, chronic pancreatitis and substance p
1) Confidence 0.46 Published 2000 Journal Ann Ital Chir Section Abstract Doc Link 10829518 Disease Relevance 1.36 Pain Relevance 1.36
CGRP produces either indirect excitatory or direct inhibitory responses by stimulation of CGRP2 and CGRP1 receptors, respectively.
Positive_regulation (stimulation) of CGRP2
2) Confidence 0.36 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10543438 Disease Relevance 0 Pain Relevance 0.60
Noteworthy is the evidence which suggests that neurotrophic factors may also induce nociception via upregulation of pain-related neuopepties such as substance P and calcitonin gene related peptide (CGRP) [19].
Positive_regulation (upregulation) of calcitonin gene associated with nociception, calcitonin gene related peptide, pain and substance p
3) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.38 Pain Relevance 0.57
Experimental inflammation produced by an intraplantar injection of complete Freund's adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides substance P and calcitonin gene related peptide in the primary sensory neurons innervating the inflamed tissue.
Positive_regulation (up-regulates) of calcitonin gene in primary sensory neurons associated with calcitonin gene related peptide, inflammation, hypersensitivity, neuropeptide and substance p
4) Confidence 0.02 Published 1994 Journal Neuroscience Section Abstract Doc Link 7530342 Disease Relevance 0.65 Pain Relevance 0.54

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