INT48908

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 13.46
Pain Relevance 8.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
pia mater 3
striatum 2
endometrium 2
nucleus accumbens 2
plasma 1
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 28 99.62 Very High Very High Very High
qutenza 81 99.42 Very High Very High Very High
gABA 39 99.42 Very High Very High Very High
Nucleus accumbens 14 98.88 Very High Very High Very High
Inflammation 147 98.84 Very High Very High Very High
amygdala 159 98.76 Very High Very High Very High
Dismenorea 15 98.68 Very High Very High Very High
long-term potentiation 74 96.56 Very High Very High Very High
endometriosis 84 96.36 Very High Very High Very High
Migraine 21 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 368 99.92 Very High Very High Very High
Cirrhosis 61 98.94 Very High Very High Very High
INFLAMMATION 161 98.84 Very High Very High Very High
Dysmenorrhea 5 98.68 Very High Very High Very High
Disease 42 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 61 98.40 Very High Very High Very High
Injury 104 97.44 Very High Very High Very High
End Stage Liver Disease 1 96.68 Very High Very High Very High
Dystonia 20 96.56 Very High Very High Very High
Endometriosis (extended) 96 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a cyclical expression of mRNA of NOS in the epithelial glands of the human endometrium.
Transcription (expression) of NOS in glands
1) Confidence 0.55 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.82 Pain Relevance 0.35
Highest levels of expression of endothelial NOS mRNA have been reported in the late secretory phase of the endometrium [115].
Transcription (expression) of NOS in endometrium
2) Confidence 0.55 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.22 Pain Relevance 0
Once conceptualized, that a specific and unique gene (eNOS, iNOS, nNOS) encodes the transcription of NO in a specific organ system, the opposing faces of this highly specialized, small, bioactive, and readily diffusible gas NO can be better understood (table 2, 3) [13].
Transcription (transcription) of nNOS in organ system
3) Confidence 0.51 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 0.91 Pain Relevance 0.03
Neither the expression of nNOS protein nor mRNA in lung tissue was increased toward the sham-injured control group at any investigated time point (Figure 2).
Transcription (expression) of nNOS in lung
4) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.80 Pain Relevance 0.06
Additionally, each NOS isoform is transcribed from a separate gene (table 1).
Transcription (transcribed) of NOS
5) Confidence 0.45 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 0.33 Pain Relevance 0
Neuronal and endothelial nitric oxide synthase immunoreactivity and NADPH-diaphorase staining in rat and human pancreas: influence of fixation.
Transcription (immunoreactivity) of oxide synthase in pancreas associated with qutenza
6) Confidence 0.43 Published 1994 Journal Histochemistry Section Title Doc Link 7532638 Disease Relevance 0.07 Pain Relevance 0.14
This study was undertaken to determine the expression of endothelial nitric oxide synthase (NOS) mRNA in ectopic endometrium in adenomyosis.
Spec (determine) Transcription (expression) of NOS in endometrium associated with dismenorea
7) Confidence 0.39 Published 2000 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11451019 Disease Relevance 0.31 Pain Relevance 0.31
Although neither mRNA nor protein expression of nNOS was increased at any of the evaluated time points, both eNOS and iNOS protein expressions started to increase early after the injury.
Transcription (expression) of nNOS associated with injury
8) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.69 Pain Relevance 0
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Transcription (transcription) of NOS in plasma associated with injury
9) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.61 Pain Relevance 0.03
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Transcription (expression) of nitric oxide synthase in pia mater associated with stress
10) Confidence 0.34 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.42
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Transcription (expression) of NOS in pia mater associated with stress
11) Confidence 0.33 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.42
Significantly augmented neuronal (n)NOS protein expression was detected in pia mater after air stress but not in dura mater.
Neg (not) Transcription (detected) of NOS in dura mater associated with stress
12) Confidence 0.22 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.49
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Transcription (expression) of NOS in pia mater associated with stress
13) Confidence 0.22 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.50
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of nitric oxide synthase in nucleus accumbens associated with nucleus accumbens and dopamine
14) Confidence 0.15 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.64
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of NOS in nucleus accumbens associated with nucleus accumbens and dopamine
15) Confidence 0.13 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.64
-amino butyric acid (GABA) and nitric oxide synthase (NOS), together with the transcription factors Nkx2.1 and Islet-1 (Isl1).
Transcription (transcription) of NOS associated with gaba
16) Confidence 0.11 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.20
Lumbar and cervical spinal cord tissue was collected from animals euthanized 1 day and 6 or 7 days after surgery and processed for cyclooxygenase (cyclooxygenase-1 and cyclooxygenase-2), neuronal NOS mRNA expression using reverse-transcription polymerase chain reaction and hybridization.
Transcription (expression) of NOS in spinal cord
17) Confidence 0.10 Published 2003 Journal Anesthesiology Section Body Doc Link 12502994 Disease Relevance 0.08 Pain Relevance 0
Moreover, NO inhibits IDO activity, thereby suppressing kynurenine formation, and at least one member of the kynurenine pathway, 3-hydroxyanthranilic acid, has been shown to inhibit NOS enzyme activity, the expression of NOS mRNA, and activation of the inflammatory transcription factor, nuclear factor-kB.
Transcription (expression) of NOS associated with inflammation
18) Confidence 0.10 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 0.93 Pain Relevance 0.55
Indeed, transcripts for eNOS and inducible nitric oxide synthase (iNOS) were found to be up-regulated on both transcriptional and translational levels during arteriogenesis [4].
Transcription (transcripts) of nitric oxide synthase
19) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.20 Pain Relevance 0.07
Indeed, transcripts for eNOS and inducible nitric oxide synthase (iNOS) were found to be up-regulated on both transcriptional and translational levels during arteriogenesis [4].
Transcription (transcriptional) of nitric oxide synthase
20) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.27 Pain Relevance 0.07

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