INT48921

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 11
Speculated 4
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 19.51
Pain Relevance 10.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
thoracic aorta 4
hippocampus 3
medulla 2
spinal cord 2
kidney cortex 2
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 235 100.00 Very High Very High Very High
Dopamine 113 99.98 Very High Very High Very High
Hippocampus 190 99.68 Very High Very High Very High
Spinal cord 256 99.66 Very High Very High Very High
Dorsal horn 56 99.16 Very High Very High Very High
Pain 435 99.06 Very High Very High Very High
Lasting pain 122 98.28 Very High Very High Very High
Rostral ventrolateral medulla 110 98.20 Very High Very High Very High
painful pain 28 97.24 Very High Very High Very High
allodynia 8 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1422 99.92 Very High Very High Very High
Urological Neuroanatomy 13 99.80 Very High Very High Very High
Pain 587 99.06 Very High Very High Very High
Stress 32 98.66 Very High Very High Very High
Death 125 98.00 Very High Very High Very High
Apoptosis 14 96.80 Very High Very High Very High
Neuropathic Pain 61 96.24 Very High Very High Very High
Nervous System Injury 16 95.48 Very High Very High Very High
Frailty 8 94.40 High High
Pheochromocytoma 1 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification by ELISA revealed that the total ERK1/2 in ventrolateral medulla was not affected by microinjection of Mev into the bilateral RVLM (fig. 2).
Neg (not) Regulation (affected) of ERK1/2 in medulla associated with medulla and rostral ventrolateral medulla
1) Confidence 0.49 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.59 Pain Relevance 0.34
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Regulation (changes) of ERK2 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
2) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.64 Pain Relevance 1.61
The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses.
Regulation (regulated) of extracellular signal-regulated kinase 1 and 2
3) Confidence 0.38 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16513110 Disease Relevance 0.39 Pain Relevance 0.32
Under the present conditions fentanyl did not affect extracellular signal-regulated protein kinase 1 and 2, Stat and cyclic AMP-response element-binding protein activity.
Neg (not) Regulation (affect) of extracellular signal-regulated protein kinase 1 and 2
4) Confidence 0.34 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535947 Disease Relevance 0 Pain Relevance 0.83
In this study, we examined the involvement of spinal ERK and p38 MAPK in each phase of i.t.
Spec (examined) Regulation (involvement) of p38 MAPK in spinal
5) Confidence 0.31 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.49 Pain Relevance 0.57
This also coincides with the biochemical hypothesis that dopamine affects ERK2 in the hippocampus via the NMDA-R.
Regulation (affects) of ERK2 in hippocampus associated with dopamine and hippocampus
6) Confidence 0.27 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.24 Pain Relevance 0.91
In contrast, the total ERK1/2 protein level was not affected by the treatment (Fig. 3D, upper panel).
Neg (not) Regulation (affected) of ERK1/2 in upper
7) Confidence 0.26 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Interestingly, the relative differences between ERK1 and ERK2 immunoreactivity were quite the same as that previous study (see the present results).
Regulation (immunoreactivity) of ERK2
8) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.09 Pain Relevance 0.34
Combined differential participation of the spinal cord, SI area, and hippocampus in the multidimensional aspects of pain experience with region- and isoform-dependent responses of pERK1 and pERK2 to peripheral noxious stimulation observed in the present study, we propose a hypothesis that this differential activation of ERK1 and ERK2 across distinct regions under pain state might suggest the possibility for a different function of specific ERK members in the nociceptive processing and further provide a molecular basis for the differential involvement of individual components of nociceptive system in the diverse features of pain.
Spec (might) Regulation (responses) of pERK2 in hippocampus associated with nociception, pain, hippocampus and spinal cord
9) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.01 Pain Relevance 1.01
However, the ERK2 enzyme seems to be more sensitive and exhibit stronger responses than ERK1 enzyme.
Regulation (sensitive) of ERK2
10) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.25 Pain Relevance 0.58
There were no significant changes in total expression levels of ERK1 or ERK2 in ipsilateral hippocampus at any time point examined (data not shown).
Neg (no) Spec (examined) Regulation (changes) of ERK2 in hippocampus associated with hippocampus
11) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.29 Pain Relevance 0.47
Quantitative blot immunolabeling techniques were used to determine the concentrations of ERK1 (M(r) 44 kDa) and ERK2 (M(r) 42 kDa), the two major extracellular signal-regulated protein kinases, in different regions of rat brain.
Regulation (concentrations) of ERK2 in brain
12) Confidence 0.25 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7532701 Disease Relevance 0 Pain Relevance 0.11
In spite of the great differences in basal expression amounts of total protein between ERK1 and ERK2 in the normal spinal cord, no significant alterations in tERK1 or tERK2 level were detected following noxious stimulation, transient or persistent, when compared to naïve rats, respectively (data not shown).
Neg (no) Regulation (alterations) of tERK2 in spinal cord associated with spinal cord
13) Confidence 0.22 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.29 Pain Relevance 0.48
Three MAPK subfamilies have been well characterized: extracellular signal regulated kinase 1 and 2 (ERK1/2), c-jun N-terminal kinases (JNK) and p38-MAPK [7].
Regulation (regulated) of p38-MAPK
14) Confidence 0.22 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.20 Pain Relevance 0.04
We speculate a differential regulation of p38-MAPK and ERK1/2 in thoracic aorta and kidneys depending upon the duration and severity of diabetes.
Regulation (regulation) of ERK1/2 in thoracic aorta associated with diabetes mellitus
15) Confidence 0.22 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.13 Pain Relevance 0.07
We speculate a differential regulation of p38-MAPK and ERK1/2 in thoracic aorta and kidneys depending upon the duration and severity of diabetes.
Regulation (regulation) of p38-MAPK in thoracic aorta associated with diabetes mellitus
16) Confidence 0.22 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.07 Pain Relevance 0.07
Three MAPK subfamilies have been well characterized: extracellular signal regulated kinase 1 and 2 (ERK1/2), c-jun N-terminal kinases (JNK) and p38-MAPK [7].
Regulation (regulated) of ERK1/2
17) Confidence 0.22 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.19 Pain Relevance 0.04
Immunoreactivity was quantified by densitometry and compared with the extracellular signal–regulated kinase 2 (ERK2) signal in each sample to correct for differences in protein loading.


Regulation (regulated) of ERK2
18) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 0.16 Pain Relevance 0.14
Results from ELISA showed that whereas the total ERK1/2 was not affected, augmented phosphorylation of ERK1/2 at Thr202 and Tyr204 in RVLM occurred preferentially during the pro-life phase of experimental brain stem death.
Neg (not) Regulation (affected) of ERK1/2 in RVLM associated with rostral ventrolateral medulla and death
19) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2848001 Disease Relevance 0.71 Pain Relevance 0.27
A similar finding, though not directly related to the present study, was shown by Purves et al. [43] where they demonstrated using cultured sensory neurons that co-treatment with high glucose and oxidative stress results in an additive effect on p38-MAPK phosphorylation without affecting ERK1/2 activation.
Neg (without) Regulation (affecting) of ERK1/2 in sensory neurons associated with stress
20) Confidence 0.16 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.93 Pain Relevance 0.03

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