INT48956

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 34
Total Number 37
Disease Relevance 13.15
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
neuronal 6
colon 4
spinal 2
neurons 2
RAW 264 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 23 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
dexamethasone 2 99.96 Very High Very High Very High
cINOD 28 99.90 Very High Very High Very High
cytokine 31 99.84 Very High Very High Very High
IPN 3 99.82 Very High Very High Very High
Paracetamol 7 99.76 Very High Very High Very High
Inflammation 87 99.52 Very High Very High Very High
Thermal hyperalgesia 6 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 3 99.84 Very High Very High Very High
Inflammatory Pain 3 99.82 Very High Very High Very High
INFLAMMATION 96 99.78 Very High Very High Very High
Hyperalgesia 14 99.44 Very High Very High Very High
Hepatotoxicity 4 98.88 Very High Very High Very High
Neuropathic Pain 3 98.52 Very High Very High Very High
Colon Cancer 12 98.28 Very High Very High Very High
Cv Unclassified Under Development 10 97.72 Very High Very High Very High
Burns 5 97.64 Very High Very High Very High
Smoke Inhalation Injury 2 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both lafutidine and capsaicin significantly suppressed the increases in MPO and iNOS activities as well as enterobacterial numbers in the mucosa.
Negative_regulation (suppressed) of Positive_regulation (increases) of iNOS
1) Confidence 0.46 Published 2000 Journal Digestion Section Body Doc Link 10671773 Disease Relevance 0.06 Pain Relevance 0
To determine if fibroblasts are a source of NO inflammatory myocardial diseases, we have studied the effect of cytokines on the inducible NO synthase (iNOS) in neonatal cardiac fibroblasts and tested whether nonsteroidal anti-inflammatory drugs can diminish the induction of iNOS.
Negative_regulation (diminish) of Positive_regulation (induction) of iNOS in fibroblasts associated with cardiomyopathy, inflammation, cinod and cytokine
2) Confidence 0.46 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8620595 Disease Relevance 0.48 Pain Relevance 0.27
This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats.
Spec (investigate) Negative_regulation (inhibition) of Spec (investigate) Positive_regulation (inducible) of iNOS associated with endotoxemia
3) Confidence 0.42 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821434 Disease Relevance 0.31 Pain Relevance 0
In addition to inhibiting cyclooxygenase (COX), the NSAIDs have recently been shown to decrease inducible nitric oxide synthase (iNOS) activity.
Negative_regulation (decrease) of Positive_regulation (inducible) of iNOS associated with cinod
4) Confidence 0.42 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.18 Pain Relevance 0.38
Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR.
Negative_regulation (inhibitors) of Positive_regulation (inducible) of iNOS associated with dexamethasone
5) Confidence 0.42 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9186887 Disease Relevance 0.06 Pain Relevance 0.05
The present study was undertaken to evaluate the effect of ONO-1714, a potent and specific inhibitor of inducible NO synthase (iNOS), on acetaminophen-induced hepatotoxicity in the rats.
Negative_regulation (inhibitor) of Neg (NO) Positive_regulation (inducible) of iNOS associated with paracetamol and hepatotoxicity
6) Confidence 0.41 Published 2003 Journal Life Sci. Section Abstract Doc Link 14654171 Disease Relevance 0.46 Pain Relevance 0.36
We have previously shown that pretreatment of BN rats with aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and misoprostol, a prostaglandin E (PGE) analog, completely prevented the development of D-penicillamine-induced autoimmunity.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of iNOS associated with autoimmune disease
7) Confidence 0.41 Published 2003 Journal Toxicology Section Abstract Doc Link 12927381 Disease Relevance 0.52 Pain Relevance 0.05
We evaluated if ONO-1714, known as an inducible nitric oxide synthase (iNOS) inhibitor, could inhibit neuronal NOS (nNOS) and exert antinociception.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of iNOS in neuronal associated with antinociception
8) Confidence 0.40 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15245789 Disease Relevance 0.22 Pain Relevance 0.46
In BOHF treated animals, cyclooxygenase-2 and iNOS inductions were inhibited in ischemic hemispheres at both the mRNA and protein levels.
Negative_regulation (inhibited) of Positive_regulation (inductions) of iNOS
9) Confidence 0.39 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880613 Disease Relevance 0.47 Pain Relevance 0.19
DISCUSSION AND CONCLUSION: Ultrasound and phonophoresis treatments probably modulate and prevent the CFA-insult-induced increase in total and regional iNOS-LI neurons.
Negative_regulation (prevent) of Positive_regulation (increase) of iNOS in neurons
10) Confidence 0.38 Published 2006 Journal Phys Ther Section Body Doc Link 16386061 Disease Relevance 0 Pain Relevance 0
The transcriptional inhibitor actinomycin D completely blocked iNOS induction as assessed by both pharmacological and biochemical criteria.
Negative_regulation (blocked) of Positive_regulation (induction) of iNOS
11) Confidence 0.38 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9374708 Disease Relevance 0 Pain Relevance 0.10
Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats.
Negative_regulation (suppression) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with ipn, diclofenac and arthritis
12) Confidence 0.37 Published 2006 Journal Phys Ther Section Title Doc Link 16386061 Disease Relevance 0.39 Pain Relevance 0.38
This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats.
Spec (investigate) Negative_regulation (inhibition) of Spec (investigate) Positive_regulation (inducible) of inducible nitric oxide synthase associated with endotoxemia
13) Confidence 0.37 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821434 Disease Relevance 0.31 Pain Relevance 0
In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol.
Negative_regulation (inhibition) of Positive_regulation (elevated) of iNOS
14) Confidence 0.37 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17916350 Disease Relevance 0.66 Pain Relevance 0.47
In addition to inhibiting cyclooxygenase (COX), the NSAIDs have recently been shown to decrease inducible nitric oxide synthase (iNOS) activity.
Negative_regulation (decrease) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with cinod
15) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.18 Pain Relevance 0.38
CONCLUSIONS: Based on these results, it is suggested that the inhibition of NO and prostaglandin E(2) over-production through suppressing iNOS and COX-2 induction and attenuation of TNF-alpha formation and neutrophil infiltration into inflammatory sites by C-PC may contribute, at least in part, to its antihyperalgesic activity.


Negative_regulation (suppressing) of Positive_regulation (induction) of iNOS in neutrophil
16) Confidence 0.37 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299804 Disease Relevance 0.14 Pain Relevance 0
Pretreatment with aminoguanidine or dexamethasone, inhibitors of inducible NO synthase (iNOS), prevented the increase in UNOXV and UcGMPV but had no impact on mean arterial pressure (BP), renal vascular resistance (RVR) or GFR.
Negative_regulation (inhibitors) of Positive_regulation (inducible) of inducible NO synthase associated with dexamethasone
17) Confidence 0.37 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9186887 Disease Relevance 0.06 Pain Relevance 0.05
Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with neuralgia and neuropathic pain
18) Confidence 0.36 Published 2007 Journal Eur J Pain Section Title Doc Link 16920373 Disease Relevance 0.10 Pain Relevance 0.78
CONCLUSIONS: The beneficial effects of these drugs in experimental uveitis are mediated, at least partly, by their inhibitory effect on NOS II induction.


Negative_regulation (effect) of Positive_regulation (induction) of NOS II
19) Confidence 0.36 Published 2004 Journal Inflamm. Res. Section Body Doc Link 15167974 Disease Relevance 0.06 Pain Relevance 0
IL-1beta-induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta-mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain.
Negative_regulation (inhibiting) of Spec (likely) Positive_regulation (induction) of iNOS associated with central sensitization, ipn and thermal hyperalgesia
20) Confidence 0.35 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.69 Pain Relevance 0.94

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