INT48993

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.02
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
bile 3
ileum 1
glands 1
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 405 100.00 Very High Very High Very High
Bile 212 100.00 Very High Very High Very High
substance P 18 99.98 Very High Very High Very High
qutenza 2 99.76 Very High Very High Very High
adenocard 1 99.76 Very High Very High Very High
Inflammation 89 93.08 High High
sodium channel 28 87.76 High High
COX-2 inhibitor 1 87.32 High High
agonist 7 81.72 Quite High
aspirin 30 78.04 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 405 100.00 Very High Very High Very High
Targeted Disruption 51 100.00 Very High Very High Very High
Respiratory Sounds 3 95.24 Very High Very High Very High
Airway Obstruction 9 94.72 High High
Pneumonia 22 93.08 High High
Shock 3 92.40 High High
Infection 34 92.12 High High
Sprains And Strains 22 91.12 High High
Cancer 2 90.20 High High
INFLAMMATION 73 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant increase in bile acid transport in cftr (-/-) and cftr (+/-) mice.
Positive_regulation (increase) of cftr in bile associated with bile
1) Confidence 0.57 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.69 Pain Relevance 0.62
We found a significant increase in bile acid transport in cftr (-/-) and cftr (+/-) mice.
Positive_regulation (increase) of cftr in bile associated with bile
2) Confidence 0.57 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.69 Pain Relevance 0.63
The most striking observation, in response to CFTR knockdown, was the downregulation of LXR-?
Positive_regulation (response) of CFTR
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0.07
The effects of PAR(1) but not PAR(2) depend on generation of prostaglandins and activation of CFTR.
Positive_regulation (activation) of CFTR
4) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17431214 Disease Relevance 0.13 Pain Relevance 0.16
These results indicate that SP mediates local responses to capsaicinoids through a mechanism involving coordinated activation of CFTR and K(+) channels.
Positive_regulation (activation) of CFTR associated with substance p
5) Confidence 0.47 Published 2008 Journal Pflugers Arch. Section Abstract Doc Link 18509672 Disease Relevance 0.20 Pain Relevance 0.42
Total amount of FA increased by 1.5-fold upon CFTR gene disruption (Figure 2).
Positive_regulation (increased) of CFTR gene
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.08 Pain Relevance 0
Cystic fibrosis (CF) mice created by targeted disruption of the murine cystic fibrosis transmembrane conductance regulator gene lack adenosine 3',5'-cyclic monophosphate (cAMP)-mediated Cl- secretion and exhibit marked intestinal complications secondary to inadequate fluid secretion.
Positive_regulation (disruption) of cystic fibrosis transmembrane conductance regulator gene associated with targeted disruption, fibrosis, adenocard and cystic fibrosis
7) Confidence 0.46 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7534995 Disease Relevance 0.54 Pain Relevance 0.33
Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands.
Positive_regulation (stimulates) of CFTR in glands associated with substance p
8) Confidence 0.44 Published 2008 Journal Pflugers Arch. Section Title Doc Link 18509672 Disease Relevance 0.24 Pain Relevance 0.44
Our studies showed that although LPS induces airway constriction in CFTR-/- and cPLA2?
Positive_regulation (constriction) of CFTR
9) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.74 Pain Relevance 0.28
inhibitor, ATK, reduced LPS-induced airway constriction in CFTR -/- mice.
Positive_regulation (induced) of CFTR
10) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.42 Pain Relevance 0.18
In this study, proteasome inhibitors- LLnL and doxorubicin enhanced the CFTR gene delivery and hence CFTR-mediated short-circuit currents.
Positive_regulation (enhanced) of CFTR gene
11) Confidence 0.43 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.58 Pain Relevance 0.09
The results from this study indicate that the CFTR is not required for normal sialylation because the BPV cells and WT cells have equivalent sialylation of cytosolic components.
Neg (not) Positive_regulation (required) of CFTR
12) Confidence 0.42 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2703207 Disease Relevance 0.16 Pain Relevance 0.04
This led us to explore the mediators involved in the induction of airway constriction in CFTR -/- mice.
Positive_regulation (induction) of CFTR
13) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.61 Pain Relevance 0.28
The major difference was, however, noted in the total amount of secreted lipids, which exhibited a 1.8-fold increase in CFTR knockdown cells (Figure 7B).
Positive_regulation (increase) of CFTR
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
With the cftr gene disruption, there was a 1,5 fold increase in the total FA amount, largely attributable to monounsaturated and saturated FA compared to controls.
Positive_regulation (increase) of cftr gene
15) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864762 Disease Relevance 0.21 Pain Relevance 0.04
In the ileum, IBAT protein densities and taurocholate uptake rates are elevated in cftr (-/-) mice > cftr (+/-) > wild-type mice.
Positive_regulation (elevated) of cftr in ileum
16) Confidence 0.38 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.23 Pain Relevance 0.26
In summary, in the widely studied cftr knockout mouse model (which clearly demonstrates intestinal pathology), the apical sodium dependent ileal bile acid transporter is expressed and functions at higher levels than in wild-type animals, with intermediate levels of IBAT expression and function in heterozygous cftr (+/-) mice.
Positive_regulation (function) of cftr in bile associated with targeted disruption and bile
17) Confidence 0.38 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.35 Pain Relevance 0.29

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