INT49060

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.59
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
dendrites 1
spinal 1
striatum 1
dorsal root ganglion 1
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 5 100.00 Very High Very High Very High
ischemia 5 99.82 Very High Very High Very High
tolerance 5 99.66 Very High Very High Very High
Hyperalgesia 7 99.56 Very High Very High Very High
Root ganglion neuron 1 99.56 Very High Very High Very High
Antinociceptive 2 99.46 Very High Very High Very High
Kinase C 2 99.44 Very High Very High Very High
antagonist 20 99.34 Very High Very High Very High
Morphine 2 99.14 Very High Very High Very High
conotoxin 1 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 5 100.00 Very High Very High Very High
Cv Unclassified Under Development 5 99.82 Very High Very High Very High
Hyperalgesia 8 99.56 Very High Very High Very High
Ganglion Cysts 10 99.36 Very High Very High Very High
Injury 72 94.04 High High
Hypoxia 5 88.40 High High
Urological Neuroanatomy 1 84.48 Quite High
Schizophrenia 28 81.44 Quite High
Pain 1 78.48 Quite High
Brain Injury 62 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reversal of morphine antinociceptive tolerance by acute spinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.
Negative_regulation (inhibition) of calmodulin-dependent protein kinase II in spinal associated with nociceptor, tolerance, antinociceptive and morphine
1) Confidence 0.45 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12650850 Disease Relevance 0 Pain Relevance 0.96
Depression of Ca(2+)/calmodulin-dependent protein kinase II in dorsal root ganglion neurons after spinal nerve ligation.
Negative_regulation (Depression) of Ca(2+)/calmodulin-dependent protein kinase II in dorsal root ganglion associated with ganglion cysts, depression, spinal nerve ligature and root ganglion neuron
2) Confidence 0.41 Published 2010 Journal J. Comp. Neurol. Section Title Doc Link 19882720 Disease Relevance 0.68 Pain Relevance 0.72
Inhibitors of NO synthase (NG-nitro-, NG-methyl-, and NG-amino-L-arginine, all 100 microM) attenuated (50-80%) the NMDA-stimulated release of [3H]NA and D-[3H]Asp, as did KN-62 (10 microM), a specific inhibitor of calmodulin kinase II.
Negative_regulation (inhibitor) of kinase II
3) Confidence 0.40 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7536805 Disease Relevance 0 Pain Relevance 0.17
Although inhibitors of kinases downstream of PI3K and PLCgamma[glycogen synthetase kinase 3 (GSK3), calmodulin-dependent protein kinase II (CAMII-K) or protein kinase C (PKC)] do not reduce mechanical hyperalgesia, hyperalgesia induced by activation of PI3K was blocked by ERK/MEK inhibitors, suggesting cross-talk from the PI3K to the ERK/MEK signalling pathway.
Negative_regulation (inhibitors) of calmodulin-dependent protein kinase II associated with hyperalgesia and kinase c
4) Confidence 0.28 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16026476 Disease Relevance 0.60 Pain Relevance 1.17
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Negative_regulation (decreased) of calmodulin-dependent protein kinase IIalpha in striatum
5) Confidence 0.14 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.16 Pain Relevance 0.06
This decrease was also induced by postsynaptic theta-burst firing alone, yet it was blocked by NMDA receptor antagonists, postsynaptic Ca2+ chelation, low concentrations of tetrodotoxin, omega-conotoxin MVIIC, calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitors and a protein synthesis inhibitor.
Negative_regulation (inhibitors) of kinase II associated with tetrodotoxin, nmda receptor antagonist and conotoxin
6) Confidence 0.10 Published 2005 Journal Nat. Neurosci. Section Abstract Doc Link 16234810 Disease Relevance 0 Pain Relevance 0.40
The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
Negative_regulation (inactivated) of nuclear alphaCaM kinase II
7) Confidence 0.09 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.08 Pain Relevance 0.31
Finally, specific blockade of calcium-calmodulin kinase II (CaMKII) and of extracellular signal-regulated kinase 1 and 2 (ERK1/2) also prevented the GABAergic effects on dendritic growth (Borodinsky et al., 2003), indicating the involvement of Ca2+ induced activation of various kinases during the differentiation of CGC dendrites (Borodinsky et al., 2003).
Negative_regulation (blockade) of calcium-calmodulin kinase II in dendrites associated with gabaergic
8) Confidence 0.04 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.34
First, in a rat four-vessel occlusion model, SPD prevented ischemia-induced inhibition of calcium/calmodulin-dependent protein kinase II (CCDPKII) [66].
Negative_regulation (inhibition) of kinase II associated with ischemia
9) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.51 Pain Relevance 0.20
These changes were blocked when an NMDA antagonist or a calcium/calmodulin protein kinase II (CaMKII) inhibitor were present in culture.
Negative_regulation (inhibitor) of kinase II associated with antagonist
10) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2893123 Disease Relevance 0.56 Pain Relevance 0.34

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