INT49105

Context Info Confidence 0.78 First Reported 1995 Last Reported 2010 Negated 3 Speculated 12 Reported most in Abstract Documents 157 Total Number 169 Disease Relevance 157.27 Pain Relevance 43.01

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)

Anatomy Link Frequency plasma 12 endothelial cells 11 monocyte 8 WBC 7 neutrophils 6 Vcam1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuritis 27 100.00 Sciatic nerve 4 100.00 ischemia 101 99.92 Inflammation 1127 99.88 cytokine 337 99.84 Angina 239 99.80 Pain score 6 99.68 Osteoarthritis 28 99.64 depression 14 99.64 cva 592 99.58

Disease Link Frequency Relevance Heat Adhesions 1028 100.00 Cancer 108 100.00 Necrosis 90 100.00 Experimental Autoimmune Neuritis 22 100.00 Hepatocellular Cancer 8 100.00 Neuritis 5 99.98 Cv Unclassified Under Development 75 99.92 Knee Osteoarthritis 12 99.84 INFLAMMATION 1364 99.80 Cv General 3 Under Development 284 99.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Accordingly, perivascular T cell accumulation was most pronounced at sites of local VCAM-1 mRNA expression.

Gene_expression (expression) of VCAM-1 mRNA in T cell

1) Confidence 0.78 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862137 Disease Relevance 0.89 Pain Relevance 0.13

In the acute phase of experimental autoimmune encephalomyelitis and neuritis VCAM-1 mRNA was expressed not only on the luminal surface of inflamed vessels but also in perivascular cells suggesting a functional role of VCAM-1 in both endothelial adhesion and local restimulation of autoantigen-specific T cells.

Gene_expression (expressed) of VCAM-1 mRNA in T cells associated with multiple sclerosis, neuritis and adhesions

2) Confidence 0.78 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862137 Disease Relevance 0.76 Pain Relevance 0.13

Our findings of increased VCAM-1 expression during ACS and perhaps APE offer a rationale for therapeutic use of cytokine and other VCAM-1 modulators.

Gene_expression (expression) of VCAM-1 associated with acute chest syndrome and cytokine

3) Confidence 0.77 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.17 Pain Relevance 0.11

The impact of chronic transfusion therapy on VCAM-1 expression is unknown.

Gene_expression (expression) of VCAM-1

4) Confidence 0.77 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.03 Pain Relevance 0.09

The relationship of these two variables showed strong positive correlation in which the magnitude of leukocyte infiltration into the synovial cavity was dependent on the concentration of soluble VCAM-1 produced in the blood.

Gene_expression (produced) of VCAM-1 in cavity

5) Confidence 0.73 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.44 Pain Relevance 0.12

Also, the relationship between these two variables showed a strong positive correlation (r = 0.98, p < 0.0005, df = 10) in which the magnitude of leukocyte infiltration was dependent on the concentration of soluble VCAM-1 produced in the blood.

Gene_expression (produced) of VCAM-1 in leukocyte

6) Confidence 0.73 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.14 Pain Relevance 0

Tumor necrosis factor-alpha (TNF-alpha) neutralization with etanercept or infliximab treatment after induction of AIA significantly reduced both macrophage infiltration and VCAM-1 expression.

Gene_expression (expression) of VCAM-1 in macrophage associated with necrosis, infliximab, cancer, etanercept and arthritis

7) Confidence 0.70 Published 2009 Journal Pain Section Abstract Doc Link 19560272 Disease Relevance 1.52 Pain Relevance 0.91

Vascular cell adhesion molecule-1 mRNA is expressed in immune-mediated and ischemic injury of the rat nervous system.

Gene_expression (expressed) of Vascular cell adhesion molecule-1 in nervous system associated with injury and adhesions

8) Confidence 0.68 Published 1996 Journal J. Neuroimmunol. Section Title Doc Link 8862137 Disease Relevance 0.88 Pain Relevance 0.12

Double-stranded RNA has been shown to induce vascular cell adhesion molecule-1 (VCAM-1) protein expression on endothelial cells.

Gene_expression (expression) of VCAM-1 in endothelial cells associated with adhesions

9) Confidence 0.67 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 0.95 Pain Relevance 0.20

Recently, a new adhesion pathway has been described between VCAM-1 expressed on cytokine stimulated endothelium and the alpha 4 beta 1 integrin complex expressed on sickle reticulocytes.

Gene_expression (expressed) of VCAM-1 in reticulocytes associated with adhesions and cytokine

10) Confidence 0.67 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 0.96 Pain Relevance 0.20

Based on these observations, the hypothesis was developed that viral infection, through double-stranded RNA intermediates, increases endothelial VCAM-1 expression leading to sickle erythrocyte adhesion to endothelium via an alpha 4 beta 1-VCAM-1--dependent mechanism.

Gene_expression (expression) of VCAM-1 in erythrocyte associated with viral infection and adhesions

11) Confidence 0.67 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 1.07 Pain Relevance 0.18

Double-stranded RNA has been shown to induce vascular cell adhesion molecule-1 (VCAM-1) protein expression on endothelial cells.

Gene_expression (expression) of vascular cell adhesion molecule-1 in endothelial cells associated with adhesions

12) Confidence 0.67 Published 1995 Journal Blood Section Abstract Doc Link 7537985 Disease Relevance 0.96 Pain Relevance 0.20

Additionally, VCAM-1 and ICAM-1 mRNA expressions were elevated in HYPER group suggesting endothelial activation due to vascular mechanical stretch.

Gene_expression (expressions) of VCAM

13) Confidence 0.64 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.74 Pain Relevance 0.07

Effect of 6-shogaol on VCAM-1 concentration in the blood of CFA treated rats

Gene_expression (concentration) of VCAM-1 in blood

14) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.37 Pain Relevance 0

Determination of soluble VCAM-1 concentration in blood samples

Gene_expression (concentration) of VCAM-1 in blood

15) Confidence 0.63 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.15 Pain Relevance 0

These experiments demonstrate the critical role of VLA-4 in the pathogenesis of EAN and show that upregulation of VCAM-1 expression contributes, at least in part, to the progression of the disease in the early stages.

Gene_expression (expression) of VCAM-1 associated with disease and neuritis

16) Confidence 0.63 Published 1998 Journal Brain Section Abstract Doc Link 9679778 Disease Relevance 1.38 Pain Relevance 0.87

VCAM-1 mRNA was absent from the center of the infarcts as well as axotomized central and peripheral nerves undergoing Wallerian degeneration.

Neg (absent) Gene_expression (absent) of VCAM-1 mRNA in peripheral nerves associated with wallerian degeneration

17) Confidence 0.60 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862137 Disease Relevance 0.91 Pain Relevance 0.13

In addition, VCAM-1 mRNA was detected in the border zone around photochemically induced cerebral infarcts which is the predeliction site of T cell infiltration and expression of immune activation markers during the first week after ischemia.

Gene_expression (detected) of VCAM-1 mRNA in T cell associated with cv general 4 under development and ischemia

18) Confidence 0.60 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862137 Disease Relevance 0.91 Pain Relevance 0.13

Levels of sVCAM-1 were further elevated during ACS (P < 0.001) and APE (P = 0.072) and returned to the asymptomatic range on resolution.

Gene_expression (Levels) of sVCAM-1 associated with acute chest syndrome

19) Confidence 0.60 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.23 Pain Relevance 0.11

Elevated plasma sVCAM-1 levels in children with sickle cell disease: impact of chronic transfusion therapy.

Gene_expression (levels) of sVCAM-1 in plasma associated with sickle cell anemia

20) Confidence 0.58 Published 2004 Journal Am. J. Hematol. Section Title Doc Link 15114598 Disease Relevance 1.13 Pain Relevance 0.12

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