INT49111

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 102
Total Number 104
Disease Relevance 27.44
Pain Relevance 71.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
brain 3
spinal 2
cerebral cortex 2
spinal cord 2
neurons 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 354 100.00 Very High Very High Very High
gABA 74 100.00 Very High Very High Very High
Nucleus accumbens 9 100.00 Very High Very High Very High
cINOD 27 99.98 Very High Very High Very High
antagonist 168 99.96 Very High Very High Very High
nMDA receptor 489 99.90 Very High Very High Very High
agonist 78 99.78 Very High Very High Very High
intrathecal 73 99.70 Very High Very High Very High
Brush evoked pain 13 99.70 Very High Very High Very High
Central grey 12 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 95 99.86 Very High Very High Very High
Neuropathic Pain 173 99.70 Very High Very High Very High
Urological Neuroanatomy 22 99.68 Very High Very High Very High
Ganglion Cysts 352 99.66 Very High Very High Very High
Hyperalgesia 97 99.60 Very High Very High Very High
Hypersensitivity 19 99.20 Very High Very High Very High
Aging 33 98.96 Very High Very High Very High
Pain 1033 98.64 Very High Very High Very High
Nociception 257 97.04 Very High Very High Very High
Arthritis 544 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of Rp-cAMPS (500 microM), a selective inhibitor of protein kinase A (PKA), decreased both SMPO and repetitive firing evoked by NE application or by intracellular current injection.
Negative_regulation (inhibitor) of PKA associated with repetitive firing
1) Confidence 0.59 Published 2003 Journal Pain Section Abstract Doc Link 14499434 Disease Relevance 0.27 Pain Relevance 0.41
Non-steroidal anti-inflammatory drugs decreased cAMP-dependent protein kinase A (PKA) activity in rat adipocyte lysates and in a commercial bovine heart PKA holoenzyme.
Negative_regulation (decreased) of PKA in adipocyte associated with inflammation and cinod
2) Confidence 0.57 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.50 Pain Relevance 0.89
The present results suggest that the glycine-induced chloride current is cAMP dependent and is inhibited by PKA, and that the potentiation of the glycine response by DAGO is also cAMP dependent and is due to the inhibition of PKA as that of H-89.
Negative_regulation (inhibition) of PKA
3) Confidence 0.52 Published 1996 Journal Brain Res. Section Abstract Doc Link 8896810 Disease Relevance 0.18 Pain Relevance 0.21
H-89, a protein kinase A (PKA) inhibitor, increased the 10(-5) M Gly response but had little effect on the 10(-4) M Gly response.
Negative_regulation (inhibitor) of PKA
4) Confidence 0.52 Published 1996 Journal Brain Res. Section Abstract Doc Link 8896810 Disease Relevance 0.22 Pain Relevance 0.33
Hippocampal-prefrontocortical circuits: PKA inhibition in the prefrontal cortex impairs delayed nonmatching in the radial maze in rats.
Negative_regulation (inhibition) of PKA in prefrontal
5) Confidence 0.50 Published 2001 Journal Behav. Neurosci. Section Title Doc Link 11770052 Disease Relevance 0.07 Pain Relevance 0.38
Rp-cAMPS (50-250 mumol/L, n = 6), a specific inhibitor of PKA, and H-89 (10 mumol/L, n = 6), an inhibitor of PKA catalytic subunit, obviously suppressed the NE-evoked excitation.
Negative_regulation (inhibitor) of PKA
6) Confidence 0.49 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11498930 Disease Relevance 0.28 Pain Relevance 0.19
Rp-cAMPS (50-250 mumol/L, n = 6), a specific inhibitor of PKA, and H-89 (10 mumol/L, n = 6), an inhibitor of PKA catalytic subunit, obviously suppressed the NE-evoked excitation.
Negative_regulation (inhibitor) of PKA
7) Confidence 0.49 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11498930 Disease Relevance 0.29 Pain Relevance 0.19
Inhibitors of PKC decreased TTX-R INa, whereas inhibitors of PKA had no effect on the current.
Negative_regulation (inhibitors) of PKA associated with kinase c
8) Confidence 0.48 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.07 Pain Relevance 0.53
We conclude that the potentiation of glycine response by DAGO is mediated by an inhibition of cAMP-dependent PKA in the PAG neurons.
Negative_regulation (inhibition) of PKA in neurons associated with central grey
9) Confidence 0.46 Published 1996 Journal Brain Res. Section Abstract Doc Link 8896810 Disease Relevance 0.17 Pain Relevance 0.16
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibition of PKA on Fos protein expression and tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and NTS/VLM during morphine withdrawal.
Negative_regulation (inhibition) of PKA in VLM associated with medulla, withdrawal and morphine
10) Confidence 0.44 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.43 Pain Relevance 1.30
Disruption of Protein Kinase A in Mice Enhances Healthy Aging

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast.

Negative_regulation (Disruption) of Protein Kinase A associated with aging and lifespan
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2693670 Disease Relevance 0.78 Pain Relevance 0
These results indicate that inhibition of PKA activation explains NSAIDs-induced decrease in adrenaline-stimulated lipolysis.
Negative_regulation (inhibition) of PKA associated with cinod
12) Confidence 0.41 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.47 Pain Relevance 1.02
The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.
Negative_regulation (decrease) of PKA associated with morphine
13) Confidence 0.41 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 0.96
In experiments using immunofluorescence staining, the numbers of phospho-NR1-like immunoreactive (p-NR1-LI) neurons seen after CAP injection were significantly decreased in the dorsal horn of the L(4)-L(5) segments on the side ipsilateral to the injection after PKA was inhibited.
Negative_regulation (inhibited) of PKA in dorsal horn associated with qutenza and dorsal horn
14) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 1.21
We investigated whether cAMP-dependent protein kinase (PKA) plays a role in this process by estimating changes in PKA immunoreactivity and the influence of inhibitor of PKA on Fos protein expression, tyrosine hydroxylase (TH) immunoreactivity levels and NA turnover in the left and right ventricle.
Negative_regulation (inhibitor) of PKA in ventricle associated with noradrenaline
15) Confidence 0.38 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.16 Pain Relevance 1.07
This isoproterenol-induced CPA was reversed by the coinjection of Rp-cyclic adenosine monophosphorothioate (Rp-cAMPS), a selective PKA inhibitor.
Negative_regulation (inhibitor) of PKA in CPA associated with adenocard
16) Confidence 0.38 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18667605 Disease Relevance 0.44 Pain Relevance 0.49
METHODS: Studies were conducted in five groups of urethane-anesthetized Sprague-Dawley rats: Group 1--control group, Group 2--a non-receptor-blocking adenylate cyclase inhibitor: SQ22536, at 100 microg/kg (n = 5), Group 3--a PKA inhibitor: H89, at 10 microg/kg, Group 4--a morphine sulfate (10 microg/kg) and PKA inhibitor group, and Group 5--an adenylate cyclase inhibited and morphine (10 microg/kg) group.
Negative_regulation (inhibitor) of PKA
17) Confidence 0.38 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18227303 Disease Relevance 0 Pain Relevance 0
RESULTS: Adenylate cyclase and PKA inhibition resulted in vascular hyperpermeability.
Negative_regulation (inhibition) of PKA
18) Confidence 0.38 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18227303 Disease Relevance 0 Pain Relevance 0
Lastly, VPA and inhibitors of adenylyl cyclase (SQ22536) and PKA (H89) were tested in in vitro models of epileptiform activity induced in hippocampal-entorhinal cortex slices using either pentylenetetrazol (2 mM) or low magnesium.
Negative_regulation (inhibitors) of PKA in cortex
19) Confidence 0.38 Published 2010 Journal Epilepsia Section Body Doc Link 20002144 Disease Relevance 0 Pain Relevance 0
Furthermore, the effect of DAMGO was preserved in the presence of a non-specific inhibitor of PKA and PKC (H7, 10microM) inside the cell.
Negative_regulation (inhibitor) of PKA
20) Confidence 0.37 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20541588 Disease Relevance 0 Pain Relevance 0.64

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