INT49211

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
globus pallidus 2
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 93 97.64 Very High Very High Very High
gABA 119 83.76 Quite High
projection neuron 1 73.60 Quite High
Nicotine 18 67.48 Quite High
agonist 4 61.48 Quite High
antagonist 8 42.84 Quite Low
Enkephalin 1 25.00 Low Low
Glutamate 10 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 136 99.84 Very High Very High Very High
Catalepsy 1 94.92 High High
Pulmonary Disease 4 86.84 High High
Generalized Anxiety Disorder 12 85.76 High High
Dyskinesias 4 79.76 Quite High
Metaplasia 6 76.48 Quite High
Hyperplasia 4 19.04 Low Low
Asthma 8 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect contrasted with the increased level of GAD67 mRNA we have previously observed in the globus pallidus after short-term haloperidol treatment (3-14 days), a regimen that induces catalepsy.
Positive_regulation (increased) of Positive_regulation (increased) of GAD67 mRNA in globus pallidus associated with catalepsy
1) Confidence 0.50 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.56 Pain Relevance 0.12
Marked up-regulation of GAD67 by cigarette smoking is associated with MUC5AC overexpression.
Positive_regulation (up) of Positive_regulation (regulation) of GAD67 associated with nicotine addiction
2) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.61 Pain Relevance 0.28
Marked up-regulation of GAD67 by cigarette smoking is associated with MUC5AC overexpression.
Positive_regulation (regulation) of Positive_regulation (up) of GAD67 associated with nicotine addiction
3) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.61 Pain Relevance 0.28

General Comments

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