INT49212

From wiki-pain
Revision as of 21:45, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 22.15
Pain Relevance 6.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
pallidum 2
neurons 2
spinal cord 1
red blood cell 1
motor neurons 1
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 27 100.00 Very High Very High Very High
gABA 265 99.80 Very High Very High Very High
Pain 16 99.74 Very High Very High Very High
Spinal cord injury pain 1 99.48 Very High Very High Very High
Duloxetine 152 99.00 Very High Very High Very High
central pain 20 98.88 Very High Very High Very High
Neuropathic pain 4 98.48 Very High Very High Very High
Central nervous system 25 97.72 Very High Very High Very High
Spinal cord 3 97.56 Very High Very High Very High
Neurotransmitter 17 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 477 100.00 Very High Very High Very High
Frailty 11 99.48 Very High Very High Very High
Primary Sclerosing Cholangitis 54 99.32 Very High Very High Very High
Pain 37 98.88 Very High Very High Very High
Catalepsy 2 98.64 Very High Very High Very High
Neuropathic Pain 6 98.48 Very High Very High Very High
Stress 37 98.30 Very High Very High Very High
Cognitive Disorder 19 98.24 Very High Very High Very High
Panic Disorder 27 98.08 Very High Very High Very High
Phobia 35 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with data indicating a loss of GAD activity in target areas of the globus pallidus in humans with tardive dyskinesia, the results suggest that decreased GABAergic transmission in the projection neurons of the external pallidum may play a critical role in the motor side effects associated with long-term neuroleptic therapy.
Negative_regulation (loss) of GAD in pallidum associated with generalized anxiety disorder, gabaergic, projection neuron and dyskinesias
1) Confidence 0.59 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.57 Pain Relevance 0.13
In contrast, only long-term haloperidol treatments (8 and 12 months) decreased GAD67 mRNA in globus pallidus (external pallidum).
Negative_regulation (decreased) of GAD67 mRNA in pallidum
2) Confidence 0.59 Published 1995 Journal Exp. Neurol. Section Abstract Doc Link 7544289 Disease Relevance 0.54 Pain Relevance 0.11
A decrease in function of the GAD enzyme can lead to less available GABA and, subsequently, heightened stimulation of muscles by motor neurons.
Negative_regulation (decrease) of GAD enzyme in motor neurons associated with gaba and generalized anxiety disorder
3) Confidence 0.51 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 1.33 Pain Relevance 0.23
The 67-70% decrease in V(GAD) was associated with a 13% decrease in total GAD activity (P=0.01) and a selective 44+/-15% decrease in GAD(67) protein (from 0.63+/-0.10 to 0.35+/-0.08 microg protein/mg tissue, P<0.05); GAD(65) protein was unchanged.
Negative_regulation (decrease) of GAD associated with generalized anxiety disorder
4) Confidence 0.49 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578600 Disease Relevance 1.51 Pain Relevance 0.36
The primary outcome will be a reduction in symptoms on the GAD-7 in the active arms relative to the non active intervention arms.


Negative_regulation (reduction) of GAD-7 in arms associated with generalized anxiety disorder
5) Confidence 0.43 Published 2010 Journal BMC Psychiatry Section Abstract Doc Link PMC2848219 Disease Relevance 1.10 Pain Relevance 0
The present study overcomes the aforementioned limitations by examining the effect of SCP in vivo, using deuterium incorporation into red blood cell cholesterol.
Spec (examining) Negative_regulation (effect) of SCP in red blood cell
6) Confidence 0.41 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2390548 Disease Relevance 0 Pain Relevance 0
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Negative_regulation (delivered) of glutamic acid decarboxylase gene in spinal cord associated with pain and spinal cord injury pain
7) Confidence 0.41 Published 2004 Journal Mol. Ther. Section Title Doc Link 15233942 Disease Relevance 1.48 Pain Relevance 1.09
In general, internet-based CBT programs have been shown to be effective for the treatment of other anxiety disorders such as Post Traumatic Stress Disorder, Social Phobia, Panic Disorder and stress in clinical trials; however there is no evidence for the use of internet CBT in the prevention of GAD.
Negative_regulation (prevention) of GAD associated with stress, panic disorder, phobia, generalized anxiety disorder and anxiety disorder
8) Confidence 0.38 Published 2010 Journal BMC Psychiatry Section Abstract Doc Link PMC2848219 Disease Relevance 1.20 Pain Relevance 0
The WebGAD trial will be the first to evaluate the use of an internet-based cognitive behavioural therapy (CBT) program contrasted with a credible control condition for the prevention of GAD and the first formal RCT evaluation of a web-based program for GAD using community recruitment.
Negative_regulation (prevention) of GAD associated with cognitive disorder and generalized anxiety disorder
9) Confidence 0.38 Published 2010 Journal BMC Psychiatry Section Abstract Doc Link PMC2848219 Disease Relevance 1.31 Pain Relevance 0
As noted above, the effectiveness of these applications for the prevention of GAD has not been evaluated.


Negative_regulation (prevention) of GAD associated with generalized anxiety disorder
10) Confidence 0.38 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2848219 Disease Relevance 1.19 Pain Relevance 0.05
In the absence of research indicating reliable risk factors for the onset of anxiety, and given that our sample was selected on the basis of symptoms, our approach for this trial is to offer a preventative program that included components found effective for both the treatment of GAD, and in the prevention of GAD.
Negative_regulation (prevention) of GAD associated with generalized anxiety disorder and anxiety disorder
11) Confidence 0.37 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2848219 Disease Relevance 0.90 Pain Relevance 0.06
Only GAD67 transfected cells were GAD67 positive, while control plasmids transfected cells were GAD67 negative (not shown).
Negative_regulation (positive) of GAD67
12) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.62 Pain Relevance 0
The 67-70% decrease in V(GAD) was associated with a 13% decrease in total GAD activity (P=0.01) and a selective 44+/-15% decrease in GAD(67) protein (from 0.63+/-0.10 to 0.35+/-0.08 microg protein/mg tissue, P<0.05); GAD(65) protein was unchanged.
Negative_regulation (decrease) of GAD associated with generalized anxiety disorder
13) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578600 Disease Relevance 1.51 Pain Relevance 0.36
The reduction in GAD(67) protein could account for a maximum of approximately 65% of the decrease in V(GAD) in vigabatrin-treated animals suggesting that inhibition of GAD(65) must have also occurred in these experiments, although product inhibition of GAD(67) by increased GABA could play a role.
Negative_regulation (inhibition) of GAD associated with gaba and generalized anxiety disorder
14) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578600 Disease Relevance 1.43 Pain Relevance 0.33
The reduction in GAD(67) protein could account for a maximum of approximately 65% of the decrease in V(GAD) in vigabatrin-treated animals suggesting that inhibition of GAD(65) must have also occurred in these experiments, although product inhibition of GAD(67) by increased GABA could play a role.
Negative_regulation (reduction) of GAD associated with gaba and generalized anxiety disorder
15) Confidence 0.35 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578600 Disease Relevance 1.50 Pain Relevance 0.36
Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein.
Negative_regulation (decrease) of GAD in cortex associated with gaba and generalized anxiety disorder
16) Confidence 0.35 Published 2001 Journal Brain Res. Section Title Doc Link 11578600 Disease Relevance 1.22 Pain Relevance 0.35
Duloxetine was equivalent to venlafaxine in the symptomatic relief of GAD and both provided greater relief than placebo.
Negative_regulation (relief) of GAD associated with generalized anxiety disorder and duloxetine
17) Confidence 0.33 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646646 Disease Relevance 0.24 Pain Relevance 0.34
Based on the microarray data, we defined "high GAD67" or "high MUC5AC" gene expression as ?
Negative_regulation (defined) of GAD67
18) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.17 Pain Relevance 0.04
Purkinje cells are enriched in glutamic acid decarboxylase (GAD), a GABA synthesizing enzyme [16].
Negative_regulation (enriched) of GAD in Purkinje cells associated with gaba and generalized anxiety disorder
19) Confidence 0.09 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.10 Pain Relevance 0.55
Neural destruction may cause central pain by depleting GABA via a number of mechanisms including inhibition of glutamate decarboxylase (GAD), restricting glutamate substrate, paralyzing reuptake and increasing the percentage of GABA uptake by glial cells.
Negative_regulation (inhibition) of GAD in glial cells associated with pain, central pain, glutamate, gaba and generalized anxiety disorder
20) Confidence 0.06 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.75 Pain Relevance 1.94

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox