INT49233

Context Info Confidence 0.44 First Reported 1995 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.99 Pain Relevance 0.27

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)

Anatomy Link Frequency blast cell 2 DNASE1 (Homo sapiens)

Pain Link Frequency Relevance Heat halothane 1 96.72 anesthesia 2 90.24 Angina 1 54.36 Inflammation 5 5.00 iatrogenic 2 5.00 Analgesic 1 5.00

Disease Link Frequency Relevance Heat Empyema 43 99.48 Suppuration 10 97.46 Adhesions 1 81.80 Dyspnea 2 78.48 Infection 22 74.64 Hypersensitivity 1 55.12 Fever 1 54.64 Angina 1 54.36 Death 8 34.40 Pneumonia 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently there has been an interest in intrapleural DNase as a possible candidate in combination with thrombolytic therapy to enhance pus drainage.44 In an animal model, the combination of recombinant tissue plasminogen activator (alteplase) and recombinant human deoxyribonnuclease (rhDNase) has been shown to be more effective in treating empyema than either agent used alone.45 Successful treatment of human empyema with intrapleural rhDNase given after intrapleural fibrinolytic therapy has been described in at least one case report.46

Regulation (effective) of Localization (deoxyribonnuclease) of DNase associated with suppuration and empyema

1) Confidence 0.44 Published 2010 Journal Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2998927 Disease Relevance 0.99 Pain Relevance 0.05

The released DNase activities do not originate from dead cells and are not influenced by blast cell formation.

Neg (not) Regulation (influenced) of Localization (released) of DNase in blast cell

2) Confidence 0.27 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.21

General Comments

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