INT49253

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 3.92
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
endothelial cells 8
plasma 4
Coronary sinus 2
umbilical vein 2
placenta 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 3 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
Pain 6 99.56 Very High Very High Very High
Angina 6 99.28 Very High Very High Very High
antagonist 4 96.64 Very High Very High Very High
cINOD 1 96.48 Very High Very High Very High
anesthesia 2 95.20 Very High Very High Very High
Cancer pain 6 93.16 High High
Osteoarthritis 35 91.48 High High
central sensitization 1 91.24 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 100.00 Very High Very High Very High
Endotoxemia 1 100.00 Very High Very High Very High
Cancer 6 99.98 Very High Very High Very High
Pain 3 99.56 Very High Very High Very High
Cv General 3 Under Development 4 99.28 Very High Very High Very High
Atherosclerosis 4 97.24 Very High Very High Very High
INFLAMMATION 2 96.28 Very High Very High Very High
Endometriosis (extended) 8 94.60 High High
Cancer Pain 6 93.16 High High
Hypotension 2 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells.
Regulation (Effects) of Gene_expression (production) of endothelin-1 in endothelial cells associated with analgesic
1) Confidence 0.61 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7550091 Disease Relevance 0 Pain Relevance 0.10
Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.
Regulation (Effects) of Gene_expression (expression) of endothelin-1 in umbilical vein associated with sprains and strains
2) Confidence 0.60 Published 2009 Journal Anesthesiology Section Title Doc Link 19104173 Disease Relevance 0.28 Pain Relevance 0.10
As tumor expression and release of ET-1 has been shown to be regulated by the local environment, location specific expression and release of ET-1 by tumor cells may provide insight into the mechanisms that underlie the heterogeneity of bone cancer pain that is frequently observed in humans with multiple skeletal metastases.
Regulation (regulated) of Gene_expression (expression) of ET-1 associated with cancer pain, cancer and metastasis
3) Confidence 0.58 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.23 Pain Relevance 0.73
Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells.
Regulation (Effects) of Gene_expression (production) of endothelin-1 in endothelial cells associated with analgesic
4) Confidence 0.45 Published 1995 Journal Biol. Pharm. Bull. Section Title Doc Link 7550091 Disease Relevance 0 Pain Relevance 0.10
Effects of estrogen on endothelin-1 levels
Regulation (Effects) of Gene_expression (levels) of endothelin-1
5) Confidence 0.44 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.10 Pain Relevance 0
Coronary sinus ET-1 levels were significantly decreased after estrogen infusion by 0.66 pmol/L (41%) in the treated group (1.60 ± 0.48 versus 0.94 ± 0.53 pmol/L, p < 0.0001), but remained unchanged in the control group after saline infusion (1.64 ± 0.29 versus 1.58 ± 0.33 pmol/L, p = NS).


Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of ET-1 in Coronary sinus
6) Confidence 0.44 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.40 Pain Relevance 0.12
The localization of ECE-1 corresponds with the previously reported distribution of ET-1 in the human placenta and is in accordance with the function of this enzyme in regulating vascular tone through synthesis of ET-1.
Regulation (regulating) of Gene_expression (synthesis) of ET-1 in placenta
7) Confidence 0.42 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.15 Pain Relevance 0.09
However, PKA activation seems to be less required for the ET-1-induced upregulation of MMP-13 and not at all necessary for the upregulation of MMP-1 since the inhibition of PKA with KT5720 does not affect the ET-1-induced overproduction of this enzyme.
Neg (not) Regulation (affect) of Gene_expression (overproduction) of ET-1-induced
8) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.35 Pain Relevance 0.16
Using cultured human aortic endothelial cells, we examined the effects of phosphoramidon, an endothelin converting enzyme (ECE) inhibitor, on the release of endogenous endothelin-1 (ET-1) and big endothelin-1 (big ET-1), and on the generation of ET-1 from exogenously applied big ET-1.
Spec (examined) Regulation (effects) of Gene_expression (generation) of ET-1 in endothelial cells
9) Confidence 0.27 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
The aims of this study were to test the hypothesis that propofol may alter strain-induced endothelin-1 (ET-1) secretion and nitric oxide production, and to identify the putative underlying signaling pathways in human umbilical vein endothelial cells.
Regulation (alter) of Gene_expression (production) of endothelin-1 in endothelial cells associated with sprains and strains
10) Confidence 0.26 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19104173 Disease Relevance 0.27 Pain Relevance 0.09
There are no any information about the effects of ibuprofen on ET production in endotoxemia.
Regulation (effects) of Gene_expression (production) of ET associated with endotoxemia
11) Confidence 0.04 Published 2002 Journal Clin. Chim. Acta Section Abstract Doc Link 11750279 Disease Relevance 0.44 Pain Relevance 0.14
[Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris].
Regulation ([Effect) of Gene_expression (peptide) of plasma endothelin in plasma associated with calcitonin gene related peptide and angina
12) Confidence 0.03 Published 2002 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Title Doc Link 12585189 Disease Relevance 0.20 Pain Relevance 0.44
We studied the effects of ANP infusion (10 ng/kg/min for 1 hour) and of inhalation of NO (20 ppm for 1 hour) on hemodynamic and respiratory patient parameters, as well as the effects on plasma levels of ANP, guanosine 3',5'-cyclic monophosphate, nitrate and endothelin-1.


Regulation (effects) of Gene_expression (levels) of endothelin-1 in plasma
13) Confidence 0.01 Published 2001 Journal Crit Care Section Abstract Doc Link PMC31579 Disease Relevance 0.50 Pain Relevance 0

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