INT49402

Context Info Confidence 0.61 First Reported 1994 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 8 Disease Relevance 4.23 Pain Relevance 1.43

pigmentation (EDA) cell differentiation (EDA) signal transduction (EDA) extracellular region (EDA) plasma membrane (EDA) cytoskeleton (EDA)

Anatomy Link Frequency blood 2 joints 2 articular 1 hepatic vein 1 parietal 1 EDA (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 19 99.70 dorsal root ganglion 46 98.96 Inflammation 182 98.84 Pain 16 96.28 Osteoarthritis 2 95.04 medulla 1 79.00 halothane 1 76.64 cytokine 29 76.32 Paracetamol 2 71.84 Autonomic response 1 68.96

Disease Link Frequency Relevance Heat Shock 9 100.00 Rheumatoid Arthritis 19 99.70 Arthritis 38 99.08 Ganglion Cysts 46 98.96 INFLAMMATION 185 97.12 Arthralgia 1 96.52 Polymyositis 1 95.64 Osteoarthritis 2 95.04 Systemic Lupus Erythematosus 13 94.96 Disease 75 93.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

METHODS: In 20 patients under general anesthesia, we assessed hepatic blood flow index in the right and middle hepatic vein by use of multiplane transesophageal echocardiography before and after induction of EDA.

Positive_regulation (induction) of EDA in hepatic vein

1) Confidence 0.61 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0

Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).

Positive_regulation (induction) of EDA in blood

2) Confidence 0.61 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0

The patients with rheumatoid arthritis showed a high level of EDA(+) FN in their plasma, and the EDA(+) FN level in plasma corresponded with changes in joint pain.

Positive_regulation (level) of EDA in joint associated with pain, arthralgia and rheumatoid arthritis

3) Confidence 0.49 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.48 Pain Relevance 0.19

Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].

Positive_regulation (activators) of EDA in articular associated with inflammation and arthritis

4) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.57 Pain Relevance 0.48

For example, a wide range of endogenous TLR activators, including heat shock proteins, HMGB1, host DNA, fibrinogen, FNEDA, and tenascin-C, are observed in synovia of RA patients but not in synovia from normal joints or non-inflamed synovia from osteoarthritis (OA) patients [106–112].

Positive_regulation (activators) of EDA in joints associated with shock, rheumatoid arthritis and osteoarthritis

5) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.18 Pain Relevance 0.24

Results are interpreted as indicating that fronto-parietal control of EDA is probably mediated by a double descending system: one involving corticoreticulospinal pathways and a direct corticospinal one.

Spec (probably) Positive_regulation (mediated) of EDA in parietal

6) Confidence 0.43 Published 1995 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 7560747 Disease Relevance 0.07 Pain Relevance 0.11

Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).

Positive_regulation (induction) of EDA-NE in blood

7) Confidence 0.41 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0

A less marked increase in ED1-positive cell numbers was observed in the contralateral DRG, reaching statistical significance only at 7 days.

Positive_regulation (increase) of ED1 associated with dorsal root ganglion

8) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.91 Pain Relevance 0.40

General Comments

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