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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 11.26
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
labyrinth 2
oligodendrocytes 2
stomach 1
T-cell 1
microglia 1
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 242 99.68 Very High Very High Very High
aspirin 69 98.56 Very High Very High Very High
Inflammation 339 98.12 Very High Very High Very High
COX-2 inhibitor 64 95.16 Very High Very High Very High
diclofenac 114 94.16 High High
Inflammatory stimuli 5 86.72 High High
gABA 56 86.64 High High
cerebral cortex 105 86.32 High High
cytokine 68 85.56 High High
Spinal cord 6 85.24 High High
Disease Link Frequency Relevance Heat
Cancer 284 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 14 99.84 Very High Very High Very High
INFLAMMATION 408 98.12 Very High Very High Very High
Disease 442 98.08 Very High Very High Very High
Nociception 3 97.78 Very High Very High Very High
Granulomatous Inflammation 3 97.40 Very High Very High Very High
Apoptosis 157 97.12 Very High Very High Very High
Toxicity 13 94.00 High High
Intestinal Cancer 10 92.36 High High
Increased Venous Pressure Under Development 18 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, NSAIDs reduce formation of both prostacyclin and thromboxane A2, with individual drugs differing in their relative blockade of COX-1 and COX-2 activities.
Localization (blockade) of COX associated with cinod
1) Confidence 0.53 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.21 Pain Relevance 0.35
In contrast, NSAIDs reduce formation of both prostacyclin and thromboxane A2, with individual drugs differing in their relative blockade of COX-1 and COX-2 activities.
Localization (blockade) of COX associated with cinod
2) Confidence 0.53 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.21 Pain Relevance 0.35
However, the present study pertained to tNSAIDs, which inhibit COX-2, but vary in their comcomitant inhibtion of COX-1 and did not include NSAIDs designed to attain specific inhibition of COX-2.
Localization (inhibtion) of COX associated with cinod
3) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.59 Pain Relevance 0.36
However, the present study pertained to tNSAIDs, which inhibit COX-2, but vary in their comcomitant inhibtion of COX-1 and did not include NSAIDs designed to attain specific inhibition of COX-2.
Localization (inhibtion) of COX associated with cinod
4) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.59 Pain Relevance 0.37
By immunocytochemistry, COX-1 and COX-2 enzymes were localized to NSCLC tumors.
Localization (localized) of COX associated with cancer and non-small-cell lung cancer
5) Confidence 0.35 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9615719 Disease Relevance 0.77 Pain Relevance 0.30
By immunocytochemistry, COX-1 and COX-2 enzymes were localized to NSCLC tumors.
Localization (localized) of COX associated with cancer and non-small-cell lung cancer
6) Confidence 0.35 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9615719 Disease Relevance 0.77 Pain Relevance 0.30
Although coupling between COX-2 and mitochondrial enzymes in brain has not been reported, mitochondrial localization of COX-2 has been reported in cancer cells and in corpus luteum [12,13].
Localization (localization) of COX in corpus luteum associated with cancer
7) Confidence 0.33 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.10 Pain Relevance 0.13
Furthermore, we demonstrate that genetic deletion of COX isoforms alters the expression of tandem genes that are involved in metabolic and signaling pathways such as ?
Localization (deletion) of COX
8) Confidence 0.31 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0 Pain Relevance 0.22
This study investigated COX activity and the distribution of COX-1 and COX-2 during the development of a murine air pouch model of chronic granulomatous inflammation.
Localization (distribution) of COX associated with granulomatous inflammation and inflammation
9) Confidence 0.31 Published 1995 Journal J. Pathol. Section Abstract Doc Link 7562257 Disease Relevance 0.49 Pain Relevance 0.36
The deletion of COX-2, normally localized at nuclear envelope [11], might affect the expression of genes directly or indirectly coupled with COX-2.
Localization (localized) of COX
10) Confidence 0.29 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.08 Pain Relevance 0.15
The selective changes in transmembrane and mitochondrial genes in COX-2-/- but not COX-1-/- may be related to the different subcellular localization of the two COX isoforms [11].
Localization (localization) of COX
11) Confidence 0.25 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.08 Pain Relevance 0.13
42 levels is independent of COX and other previously identified targets of these drugs, such as NF?
Localization (targets) of COX
12) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1948891 Disease Relevance 0.22 Pain Relevance 0.31
We found COX-1 expressed in microglia, some of them in close proximity to L-PGDS-positive oligodendrocytes and co-localization of COX-1 with L-PGDS in perivascular and leptomeningeal cells under control conditions.
Localization (co-localization) of COX in oligodendrocytes
13) Confidence 0.22 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.30 Pain Relevance 0.30
We found COX-1 expressed in microglia, some of them in close proximity to L-PGDS-positive oligodendrocytes and co-localization of COX-1 with L-PGDS in perivascular and leptomeningeal cells under control conditions.
Localization (co-localization) of COX in oligodendrocytes
14) Confidence 0.22 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.31 Pain Relevance 0.31
It also has to be noted that the protective effects of NSAIDs may be via non-COX-inhibitory mechanisms, such as lowering of A?
Localization (lowering) of COX associated with cinod
15) Confidence 0.17 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.80 Pain Relevance 0.43
Dual-labelling revealed strong co-localisation for COX-1 and COX-2 in the spongiotrophoblast and GCs in the JZ, and within the syncytiotrophoblast and cytotrophoblast cells in the labyrinth (Fig. 5c).
Localization (localisation) of COX in labyrinth
16) Confidence 0.14 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.34 Pain Relevance 0
Dual-labelling revealed strong co-localisation for COX-1 and COX-2 in the spongiotrophoblast and GCs in the JZ, and within the syncytiotrophoblast and cytotrophoblast cells in the labyrinth (Fig. 5c).
Localization (localisation) of COX in labyrinth
17) Confidence 0.14 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.34 Pain Relevance 0
Again there was strong co-localisation between immunoreactivity for COX-2 and HNE (Fig. 3c).


Localization (localisation) of COX
18) Confidence 0.14 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.24 Pain Relevance 0
The mechanisms by which COX-1 and COX-2 deficiency decrease tumorigenesis are still unknown.
Localization (decrease) of COX
19) Confidence 0.13 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11745453 Disease Relevance 0.77 Pain Relevance 0.04
Our data confirm the anti-nociceptive activities of the WEDC and indicate that this effect could be associated with inhibition of cyclooxygenase-2 (COX-2) and nitric oxide release.
Localization (release) of COX associated with nociception
20) Confidence 0.10 Published 2003 Journal Life Sci. Section Abstract Doc Link 12927589 Disease Relevance 0.45 Pain Relevance 0.29

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