INT49650

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.38
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Anatomy Link Frequency
Schwann cells 1
Nf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 97.04 Very High Very High Very High
Pain 2 92.64 High High
Spinal cord 2 89.76 High High
headache 1 83.12 Quite High
tetrodotoxin 1 79.76 Quite High
cytokine 2 75.20 Quite High
imagery 1 74.80 Quite High
Thoracotomy 1 65.68 Quite High
Antihistamine 1 50.24 Quite High
Disease Link Frequency Relevance Heat
Watson Syndrome 9 100.00 Very High Very High Very High
Neurofibroma 5 99.98 Very High Very High Very High
Nerve Sheath Neoplasms 9 97.48 Very High Very High Very High
Cancer 7 94.32 High High
Neurologic Manifestations 1 93.64 High High
Pain 2 92.64 High High
Congenital Anomalies 1 92.40 High High
Malignant Neoplastic Disease 3 90.96 High High
Plexiform Neurofibroma 5 90.32 High High
Spinal Cord Compression 1 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is increasing evidence that loss of NF1 expression in neoplastic Schwann cells is associated with elevated levels of activated RAS, supporting the notion that the NF1 gene product, neurofibromin, acts as a growth regulator by inhibiting ras growth-promoting activity.
Gene_expression (expression) of NF1 in Schwann cells associated with watson syndrome
1) Confidence 0.76 Published 2002 Journal Neurology Section Abstract Doc Link 12041525 Disease Relevance 1.21 Pain Relevance 0.16
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with variable expression.
Gene_expression (expression) of Neurofibromatosis type 1 associated with watson syndrome
2) Confidence 0.50 Published 2006 Journal Semin Pediatr Neurol Section Abstract Doc Link 16818170 Disease Relevance 1.44 Pain Relevance 0.17
Several well characterized cis-elements, including AP2, CREB, NF1, and NFkB, reside on this region of the rENK gene.
Gene_expression (reside) of NF1
3) Confidence 0.44 Published 1995 Journal Mol. Neurobiol. Section Abstract Doc Link 7576307 Disease Relevance 0 Pain Relevance 0.31
Three neurofibromas had associated neurofibromatosis type 1 (NF1).
Gene_expression (had) of associated neurofibromatosis type 1 associated with watson syndrome and neurofibroma
4) Confidence 0.22 Published 2010 Journal Eur Spine J Section Abstract Doc Link 19798517 Disease Relevance 0.73 Pain Relevance 0.03

General Comments

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