INT49747

Context Info Confidence 0.72 First Reported 1994 Last Reported 2010 Negated 0 Speculated 3 Reported most in Abstract Documents 68 Total Number 71 Disease Relevance 9.01 Pain Relevance 53.78

signal transducer activity (Oprm1)

Anatomy Link Frequency caudate-putamen 5 brain 5 RVM 4 nucleus accumbens 4 hypothalamus 3 Oprm1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 256 100.00 Opioid 80 100.00 mu opioid receptor 58 100.00 Pain 16 100.00 Neuropeptide 2 100.00 projection neuron 10 99.98 Catechol-O-methyltransferase 3 99.96 Enkephalin 46 99.90 Nucleus accumbens 49 99.84 Morphine 91 99.82

Disease Link Frequency Relevance Heat Pain 11 100.00 Urological Neuroanatomy 40 99.84 Stress 26 99.78 INFLAMMATION 9 99.36 Diabetes Mellitus 10 98.40 Injury 12 98.08 Temporomandibular Joint Syndrome 5 98.04 Cocaine Dependence 2 96.60 Myalgia 2 95.68 Hyperalgesia 6 94.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone.

Transcription (levels) of mu opioid receptor associated with mu opioid receptor and morphine

1) Confidence 0.72 Published 1995 Journal Brain Res. Bull. Section Title Doc Link 7583338 Disease Relevance 0.07 Pain Relevance 0.97

CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone.

Transcription (levels) of MOR-1 associated with mu opioid receptor and morphine

2) Confidence 0.72 Published 1995 Journal Brain Res. Bull. Section Title Doc Link 7583338 Disease Relevance 0.07 Pain Relevance 0.97

The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.

Transcription (detectable) of MOR1B

3) Confidence 0.72 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29

The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.

Transcription (detectable) of MOR1A

4) Confidence 0.72 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29

The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.

Transcription (detectable) of MOR1

5) Confidence 0.72 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29

An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats.

Transcription (levels) of mu-opioid receptor in frontal cortex associated with urological neuroanatomy and opioid receptor

6) Confidence 0.69 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950784 Disease Relevance 0.17 Pain Relevance 0.53

The sequence analyses indicate that the transcripts from rat peritoneal macrophages are identical to those for the mu-opioid receptor described in the rat brain.

Transcription (described) of mu-opioid receptor in brain associated with opioid receptor

7) Confidence 0.69 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7733926 Disease Relevance 0 Pain Relevance 0.45

The distribution of the mRNA of different C-terminal splice variants of the mu-opioid receptor in rat CNS was assessed by RT-PCR.

Transcription (distribution) of mu-opioid receptor associated with opioid receptor

8) Confidence 0.69 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.12

Northern blotting and in situ hybridization histochemistry revealed that the mu-opioid receptor mRNA was expressed in many brain regions, including cerebral cortex, caudate putamen, nucleus accumbens, olfactory tubercle, septal nuclei, thalamus, hippocampus, and medial habenular nucleus, in keeping with the known distribution of the mu-opioid receptor.

Transcription (distribution) of mu-opioid receptor in caudate putamen associated with nucleus accumbens, hippocampus, thalamus, opioid receptor and cerebral cortex

9) Confidence 0.68 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8189219 Disease Relevance 0 Pain Relevance 0.85

Distribution and immunodensity changes of the mu-opioid receptor, the neurokinin-1 receptor, and brain nitric oxide synthase distribution were assessed in the superficial dorsal horn, laminae I-II, of the lumbar spinal cord of the rat.

Transcription (distribution) of mu-opioid receptor in spinal cord associated with dorsal horn, opioid receptor and spinal cord

10) Confidence 0.66 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466461 Disease Relevance 0.89 Pain Relevance 0.63

The highest levels of mu-receptor mRNA were detected in the thalamus, medial habenula, and the caudate putamen; however, significant hybridization was also observed in many other brain regions, including the hypothalamus.

Transcription (detected) of mu-receptor mRNA in thalamus associated with thalamus

11) Confidence 0.64 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7798908 Disease Relevance 0 Pain Relevance 0.61

The present study aimed to analyze the long-term effects of a brief handling (1 min) on morphine and ethanol dependence and on the preproenkephalin (PPE) mRNA and mu opioid receptor levels.

Transcription (levels) of mu opioid receptor associated with addiction, mu opioid receptor and morphine

12) Confidence 0.64 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16567006 Disease Relevance 0.24 Pain Relevance 0.68

Moreover, the mRNA level of opioid mu-receptor in the liver markedly increased in STZ-diabetic rats compared to normal rats.

Transcription (level) of mu-receptor in liver associated with diabetes mellitus and opioid

13) Confidence 0.62 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11544560 Disease Relevance 0.86 Pain Relevance 0.86

To explore neuropharmacological interactions between methadone maintenance and cocaine conditioning, we quantitatively measured mRNA levels of mu-opioid receptor (MOR) and proopiomelanocortin genes 10 days after methadone maintenance.

Transcription (levels) of mu-opioid receptor associated with opioid receptor, methadone and cocaine

14) Confidence 0.61 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16237390 Disease Relevance 0.15 Pain Relevance 1.71

Mu-opioid receptor trafficking on inhibitory synapses in the rat brainstem.

Transcription (trafficking) of Mu-opioid receptor in brainstem associated with medulla and opioid receptor

15) Confidence 0.60 Published 2004 Journal J. Neurosci. Section Title Doc Link 15317860 Disease Relevance 0 Pain Relevance 0.80

The data also suggest that common variants in OPRM1 and specific 'high pain sensitivity'COMT haplotypes may not be the cause of high opioid needs.

Transcription (sensitivity) of OPRM1 associated with catechol-o-methyltransferase, pain and opioid

16) Confidence 0.57 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19167252 Disease Relevance 1.07 Pain Relevance 1.90

To investigate the participation of the opioid system in this phenomenon, we examined the effects of acute and repeated AMPH administration on mu-opioid receptor (MOR) mRNA levels in the nucleus accumbens (NAc) and striatum (STR) of rats, by quantitative non-radioactive in situ hybridization.

Transcription (levels) of mu-opioid receptor in NAc associated with nucleus accumbens, opioid receptor and opioid

17) Confidence 0.55 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10350632 Disease Relevance 0 Pain Relevance 0.58

The results were as follows: (1) The distribution of the mu receptor in the rat central nervous system was consistent in general with the results reported previously. (2) After EA of Tsu-San-Li, the mu receptor binding sites were increased significantly in the following examined structures: the caudate nucleus, septal nucleus, medial preoptic area, amygdalaoid nucleus, periaqueducal gray, interpeduncular nucleus, nucleus raphe magnus, and cervical and lumbar enlargements.

Transcription (distribution) of mu receptor in caudate nucleus associated with raphe magnus, urological neuroanatomy, central nervous system and electroacupuncture

18) Confidence 0.54 Published 1997 Journal Acupunct Electrother Res Section Abstract Doc Link 9494624 Disease Relevance 0.19 Pain Relevance 0.58

We observed an increase in mu-opioid receptor mRNA levels in the ventromedial nucleus of the hypothalamus (VMH) and arcuate nucleus (ARN) after 48 h of 10 microg of 17-beta-estradiol-3-benzoate treatment when compared to OVX females.

Transcription (levels) of mu-opioid receptor in hypothalamus associated with opioid receptor

19) Confidence 0.53 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.40

No effects of estrogen were observed on mu-opioid receptor mRNA levels in the posterior medial nucleus of the amygdala (MeAmyg), hippocampus, caudate-putamen (CPu) or the medial habenula.

Transcription (levels) of mu-opioid receptor in caudate-putamen associated with hippocampus, opioid receptor and amygdala

20) Confidence 0.53 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.43

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